|Table of Contents|

Efficacy and influencing factors of neoadjuvant chemotherapy in 167 cases with stage Ⅱ,Ⅲ breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2015 13
Page:
1823-1827
Research Field:
Publishing date:

Info

Title:
Efficacy and influencing factors of neoadjuvant chemotherapy in 167 cases with stage Ⅱ,Ⅲ breast cancer
Author(s):
Zhang Xiaofei1Qin Qinghong1Lian Bin1Yu Yinghua1Huang Zhen1Yang Weiping2Wei Changyuan1Mo Qinguo1
1.Department of Breast Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Guangxi Nanning 530021,China;2.Ultrasonic Department,The Affiliated Tumor Hospital of Guangxi Medical University,Guangxi Nanning 530021,China.
Keywords:
breast cancerneoaduvant chemotherapyefficacyinfluencing factor
PACS:
R730.53;R737.9
DOI:
10.3969/j.issn.1672-4992.2015.13.12
Abstract:
Objective:To investigate the efficacy and influencing factors of neoadjuvant chemotherapy in breast cancer.Methods:All 167 cases with operable stage Ⅱ,Ⅲ breast cancer were treated with anthracycline or paclitaxel class-based neoadjuvant chemotherapy,the efficacy was evaluated by MRI imaging methods.Factors affecting the effect of chemotherapy was determinated by univariate analysis and multivariate Logistic regression analysis.Results:In the 167 breast cancer patients,complete remission (CR) was obsered in 24 cases (14.4%),pathological complete response (pCR) 20 cases (12%),partial remission (PR) 90 cases (53.9%),stable disease (SD) 43 cases (25.7%),progressive disease (PD) 10 cases (6%).The overall effective rate was 68.3%.Univariate analysis showed that:Influence facters,such as tumor size,calcification,ER and PR status,chemotherapy cycles and chemotherapy regimens,on neoadjuvant chemotherapy for breast cancer was statistically significant (P<0.05).In patients whose tumor diameter ≤3cm,mammography no calcification,ER or PR negative,the number of chemotherapy cycles≥4,Anthracycline plus Xeloda regimen,the efficacy of neoadjuvant chemotherapy was better,CR rate was higher.Multivariate analysis showed that:Tumor size was an independent predictive factor for CR rate to neoadjuvant chemotherapy.With the increase in tumor size,CR rate gradually decreased.Conclusion:The neoaduvant chemotherapy for breast cancer have a good recent effect,but its efficacy is impacted by various factors,such as tumor size,calcification,ER and PR status,chemotherapy cycles and chemotherapy regimens.

References:

[1]Spanheimer PM,Carr JC,Thomas A,et al.The response to neoadjuvant chemotherapy predicts clinical outcome and increases breast conservation in advanced breast cancer[J].Am J Surg,2013,206(1):2-7.
[2]Yu Y,Xiang H,He XM,et al.Predictive factors determining neoadjuvant chemotherapy outcomes in breast cancer-a single center experience[J].Asian Pac J Cancer Prev,2013,14(4):2401-2406.
[3]Zhou LY,Shi YH,Wang X,et al.Efficacy of neoadjuvant chemotherapy in patients with triple-negative breast cancer and prognostic analysis[J].Tumor,2014,34(5):454-457.[周立艳,史业辉,汪旭,等.三阴性乳腺癌新辅助化疗疗效及预后分析[J].肿瘤,2014,34(5):454-457.]
[4]Kawajiri H,Takashima T,Aomatsu N,et al.Prognostic significance of pathological complete response following neoadjuvant chemotherapy for operable breast cancer[J].Oncol Lett,2014,7(3):663-668.
[5]Hammond ME,Hayes DF,Dowsett M,et al.American society of clinical oncology/college of American pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer[J].Arch Pathol Lab Med,2010,134(6):907-922.
[6]Hu XC,Wang BY,Shao ZM.The comparison of 《St.Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011》 and guidelines for chinese anti-cancer association,committee of breast cancer society[J].Chin J Breast Dis(Electronic Version),2011,5(4):404-407.[胡夕春,王碧芸,邵志敏.2011年《St.Gallen早期乳腺癌初治治疗国际专家共识》与中国抗癌协会乳腺癌专业委员会指南之比较[J].中华乳腺病杂志(电子版),2011,5(4):404-407.]
[7]Sun B,Song ST,Jiang ZF,et al.Analysis of the factors affecting pathologic complete response to neoadjuvant chemotherapy in breastcancer patients[J].Chin J Oncol,2013,35(1):38-42.[孙冰,宋三泰,江泽飞,等.乳腺癌新辅助化疗病理完全缓解的影响因素分析[J].中华肿瘤杂志,2013,35(1):38-42.]
[8]Straver ME,Van Adrichem JC,Rutgers EJ,et al.Neoadjuvant systemictherapy in patients with operable primary breast cancer:more benefits than breast-conserving therapy[J].Ned Tijdschr Geneeskd,2008,152(46):2519-2525.
[9]Gao DZ,Fu QY,Zhang Q,et al.The effect of 6 cycles ET neoadjuvant chemotherapy regimen on breast cancer and its influencing factors[J].Chin J General Surg,2012,27(5):398-401.[高德宗,傅勤烨,张强,等.乳腺癌6周期ET方案新辅助化疗的疗效及其影响因素分析[J].中华普通外科杂志,2012,27(5):398-401.]
[10]Weiss A,Lee KC,Romero Y,et al.Calcifications on mammogram do not correlate with tumor size after neoadjuvant chemotherapy[J].Ann Surg Oncol,2014,21(10):3310-3316.
[11]Zhang HT,Zhao YB,Song PJ,et al.Application of molybdenum target mammography to evaluation of neoadjuvant chemotherapy in breast cancer[J].Military Medical Sciences,2012,36(8):616-618.[张洪涛,赵一冰,宋培记,等.钼靶乳腺摄像在乳腺癌新辅助化疗疗效评价中的应用[J].军事医学,2012,36(8):616-618.]
[12]Jiang L,Ma T,Moran MS,et al.Mammographic features are associated with clinicopathological characteristics in invasive breast cancer[J].Anticancer Res,2011,31(6):2327-2334.
[13]Holmberg L,Wong YN,Tabár L,et al.Mammography casting-type calcification and risk of local recurrence in DCIS:analyses from a randomised study[J].Br J Cancer,2013,108(4):812-819.
[14]Krishnan Y,Alawadhi SA,P SS,et al.Pathological responses and long-term outcome analysis after neoadjuvant chemotheraphy in breast cancer patients from Kuwait over a period of 15 years[J].Ann Saudi Med,2013,33(5):443-450.
[15]Han S,Kim J,Lee J,et al.Comparison of 6 cycles versus 4 cycles of neoadjuvant epirubicin plus docetaxel chemotherapy in stages II and III breast cancer[J].Eur J Surg Oncol,2009,35(6):583-587.

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Last Update: 2015-05-29