|Table of Contents|

The expression level and biological function of DRG1 in hepatocellular carcinoma cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 02
Page:
178-185
Research Field:
Publishing date:

Info

Title:
The expression level and biological function of DRG1 in hepatocellular carcinoma cells
Author(s):
ZHU Xuanhao1; DANG Yuting1; LI Can2; BIAN Huijie2; LIU Zekun2
1.No.5 Cadet Regiment,School of Basic Medical Sciences,Air Force Medical University,Shaanxi Xi’an 710032,China;2.Department of Cell Biology,School of Basic Medical Sciences & National Translational Science Center for Molecular Medicine,Air Force Medical University,Shaanxi Xi’an 710032,China.
Keywords:
hepatocellular carcinoma; developmentally regulated GTP-binding protein 1; prognosis; oncogenic function
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2025.02.003
Abstract:
Objective:To investigate the expression level,prognostic value and biological function of developmentally regulated GTP-binding protein 1 (DRG1) in hepatocellular carcinoma (HCC) cells.Methods:The expression of DRG1 in HCC was analyzed using TCGA and ICGC.Kaplan-Meier survival curve and cox proportional risk regression were used to analyze the effect of DRG1 expression level on overall survival of HCC patients and its prognostic value.The mRNA and protein expression levels of DRG1 in HCC cells were detected by qRT-PCR and Western blot.Loss- and gain-of-function studies in vitro were used to explore the effect of DRG1 on proliferation,apoptosis,migration and invasion of HCC cells.Results:The expression of DRG1 in HCC cells was significantly higher than that in adjacent tissues,and high expression of DRG1 with HCC patients had poor prognosis,and DRG1 could be used as an independent risk factor affecting the prognosis of HCC patients.Compared with the control group,DRG1 knockdown inhibited the proliferation,migration,invasion and promotion of apoptosis of HCC cells.Overexpression of DRG1 promoted the proliferation,migration,invasion and inhibition of apoptosis of HCC cells.Conclusion:Compared with adjacent tissues,DRG1 is highly expressed in HCC,which is closely related to malignant clinical features and poor prognosis of HCC.Overexpression of DRG1 promotes the proliferation,migration,invasion and inhibition of apoptosis of HCC cells.

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Memo

Memo:
National Natural Science Foundation of China（No.82203336，82130084）;国家自然科学基金（编号：82203336，82130084）；肿瘤生物学国家重点实验室(第四军医大学)（编号：CBSKL2022ZZ49）；陕西省重点研发计划项目（编号：2023-YBSF-241）
Last Update: 1900-01-01