|Table of Contents|

Progress in mechanisms and biomarkers of immune-related adverse events induced by anti-PD-1/PD-L1

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 05
Page:
953-957
Research Field:
Publishing date:

Info

Title:
Progress in mechanisms and biomarkers of immune-related adverse events induced by anti-PD-1/PD-L1
Author(s):
TIAN ShaoqiCHEN Wenming
1.Jining Medical University,Clinical Medical College,Shandong Jining 272002,China;2.Oncology Department,the First People's Hospital of Jining,Shandong Jining 272002,China.
Keywords:
PD-1PD-L1immune-related adverse events
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2024.05.029
Abstract:
PD-1/PD-L1 antibody is a widespread used immune checkpoint inhibitor in tumor immunotherapy,which has made great achievements,but it also leads to irAEs,which can even lead to patient death in severe cases.Therefore,it is important to clarify the mechanism and early prediction of irAEs.In this paper,we summarize the pathogenic mechanisms of irAEs by the cell,immune system and individual level and sum up its risk factors and biomarkers.

References:

[1]FREITES MA,SANTANA N,ARIAS SS,et al.Using the common terminology criteria for adverse events (CTCAE - Version 5.0) to evaluate the severity of adverse events of anticancer therapies .CTCAE versión 5.0 evaluación de la gravedad de los eventos adversos dermatológicos de las terapiasantineoplásicas [J].Actas Dermo-Sifiliográficas,2021,112(1):90-92.
[2]JING Y,ZHANG YC,WANG J,et al.Association between sex and immune-related adverse events during immune checkpoint inhibitor therapy [J].Journal of the National Cancer Institute,2021,113(10):1396-1404.
[3]DOUGLAS B JOHNSON,CAROLINE A NEBHAN,JAVID J MOSLEHI,et al.Immune-checkpoint inhibitors:long-term implications of toxicity [J].Nature Reviews Clinical Oncology,2022,19(4):254-267.
[4]GE XX,JIANG WP,LI HQ,et al.Immune-related adverse events and outcomes among pan-cancer patients receiving immune checkpoint inhibitors:A monocentric real-world observational study[J].Cancer Med,2023,12(18):18491-18502.

[5]MANUEL RAMOS-CASALS,JULIE R BRAHMER,MARGARET K CALLAHAN,et al.Immune-related adverse events of checkpoint inhibitors [J].Nature Reviews Disease Primers,2020,6(1):38.
[6]NAMRATA SINGH,ANNE M HOCKING,JANE H BUCKNER.Immune-related adverse events after immune check point inhibitors: Understanding the intersection with autoimmunity [J].Immunol Rev,2023,318(1):81-88.
[7]DOUGLASB JOHNSON,JUSTIN M BALKO,MARGARET L COMPTON,et al.Fulminant myocarditis with combination immune checkpoint blockade[J].New England Journal of Medicine,2016,375(18):1749-1755.
[8]ALEXANDER X LOZANO,AADEL A CHAUDHURI,AISHWARYA NENE,et al.T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma[J].Nat Med,2022,28(2):353-362.
[9]ADRIENNE M LUOMA,SUO SB,HANNAH L WILLIAMS,et al.Molecular pathways of colon inflammation induced by cancer immunotherapy[J].Cell,2020,182(3):655-671.
[10]YUKIHIRO TOI,SHUNICHI SUGAWARA,JUN SUGISAKA,et al.Profiling preexisting antibodies in patients treated with anti–PD-1 therapy for advanced non–small cell lung cancer[J].JAMA Oncology,2019,5(3):376-383.
[11]OMAR HASAN ALI,DAVID BOMZE,SANDRA S RING,et al.BP180-specific IgG is associated with skin adverse events,therapy response,and overall survival in non-small cell lung cancer patients treated with checkpoint inhibitors [J].Journal of the American Academy of Dermatology,2020,82(4):854-861.
[12]SHANNON M LIUDAHL,LISA M COUSSENS.B cells as biomarkers:predicting immune checkpoint therapy adverse events [J].The Journal of Clinical Investigation,2018,128(2):577-579.
[13]KAVITA M DHODAPKAR,ALYSSA DUFFY ,MADHAV V DHODAPKAR.Role of B cells in immune-related adverse events following checkpoint blockade [J].Immunol Rev,2023,318(1):89-95.
[14]SU Y LIM, JENNY H LEE, TUBA N GIDE,et al.Circulating cytokines predict immune-related toxicity in melanoma patients receiving anti-PD-1 based immunotherapy circulating cytokines predict immunotherapy toxicity [J].Clinical Cancer Research,2019,25(5):1557-1563.
[15]WANG M, ZHAI XY, LI J,et al.The role of cytokines in predicting the response and adverse events related to immune checkpoint inhibitors[J].Front Immunol,2021,12:670391.
[16]SANJEEV MARIATHASAN,SHANNON J TURLEY,DOROTHEE NICKLES,et al.TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells[J].Nature,2018,554(7693):544-548.
[17]JIAO SP,SUMIT K SUBUDHI,ANA APARICIO,et al.Differences in tumor microenvironment dictate T helper lineage polarization and response to immune checkpoint therapy[J].Cell,2019,179(5):1177-1190.
[18]JEE HYE KANG,JEFFREY A BLUESTONE,ARABELLA YOUNG.Predicting and preventing immune checkpoint inhibitor toxicity: targeting cytokines[J].Trends in Immunology,2021,42(4):293-311.
[19]KARLA A LEE,HEATHER SHAW,VRONIQUE BATAILLE,et al.Campylobacteriosis following immunosuppression for immune checkpoint inhibitor-related toxicity[J].Journal for ImmunoTherapy of Cancer,2020,8(2):e000577.
[20]MILES C ANDREWS,CONNIE PM DUONG,VANCHESWARAN GOPALAKRISHNAN,et al.Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade[J].Nature Medicine,2021,27(8):1432-1441.
[21]ALESSIOCORTELLINI,MELISSA BERSANELLI,DANIELE SANTINI,et al.Another side of the association between body mass index (BMI) and clinical outcomes of cancer patients receiving programmed cell death protein-1 (PD-1)/ Programmed cell death-ligand 1 (PD-L1) checkpoint inhibitors:A multicentre analysis of immune-related adverse events[J].Eur Cancer,2020,128:17-26.
[22]SEOHYUN KIM,JEONG UK LIM.Immune checkpoint inhibitor-related interstitial lung disease in patients with advanced non-small cell lung cancer:systematic review of characteristics,incidence,risk factors,and management[J].Thorac Dis,2022,14(5):1684-1695.
[23]ALEJANDRO MERAZ-MUOZ,EITAN AMIR,PAMELA NG,et al.Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence,risk factors and outcomes [J].Journal for Immunother Therapy of Cancer,2020,8(1):e000467.
[24]NAOTO OKADA,RIE MATSUOKA,TAKUMI SAKURADA,et al.Risk factors of immune checkpoint inhibitor-related interstitial lung disease in patients with lung cancer: a single-institution retrospective study [J].Sci Rep,2020,10(1):13773.
[25]MEGHANA KESIREDDY,ALISSA MARR,MAKAYLA SCHISSEL,et al.A retrospective analysis of immune checkpoint inhibitors in patients with preexisting organ dysfunction [J].Cancer,2023,129(22):3603-3619.
[26]SATYA DAS,DOUGLAS B JOHNSON.Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors[J].Journal for Immunother Therapy of Cancer,2019,7(1):306.
[27]YOSHIHIKOSAKATA,KODAI KAWAMURA,KAZUYA ICHIKADO,et al.The association between tumor burden and severe immune-related adverse events in non-small cell lung cancer patients responding to immune-checkpoint inhibitor treatment[J].Lung Cancer,2019,130:159-161.
[28]KHOJA L,DAY D,WEI WCT,et al.Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors:a systematic review [J].Annals of Oncology,2017,28(10):2377-2385.
[29]SAEKA EGAMI,HITOSHI KAWAZOE,HIRONOBU HASHIMOTO,et al.Absolute lymphocyte count predicts immune-related adverse events in patients with non-small-cell lung cancer treated with nivolumab monotherapy:A multicenter retrospective study[J].Frontiers in Oncology,2021,11:618570.
[30]CHU XL,ZHAO J,ZHOU J,et al.Association of baseline peripheral-blood eosinophil count with immune checkpoint inhibitor-related pneumonitis and clinical outcomes in patients with non-small cell lung cancer receiving immune checkpoint inhibitors[J].Lung Cancer,2020,150:76-82.
[31]LEE PY,KELLYNN QI XUAN OEN,GRACE RUI SI LIM,et al.Neutrophil-to-lymphocyte ratio predicts development of immune-related adverse events and outcomes from immune checkpoint blockade:A case-control study[J].Cancers,2021,13(6):1308.
[32]SAEKA EGAMI,HITOSHI KAWAZOE,HIRONOBU HASHIMOTO,et al.Peripheral blood biomarkers predict immune-related adverse events in non-small cell lung cancer patients treated with pembrolizumab: a multicenter retrospective study[J].Journal of Cancer,2021,12(7):2105-2112.
[33]KEITARO SHIMOZAKI,YASUTAKA SUKAWA,YASUNORI SATO,et al.Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data [J].Future Oncology,2021,17(20):2593-2603.
[34]AAMIR-REZA ABOLHASSANI,GEROLD SCHULER,MICHAEL CONSTANTIN KIRCHBERGER,et al.C-reactive protein as an early marker of immune-related adverse events [J].Journal of Cancer Research and Clinical Oncology,2019,145(10):2625-2631.
[35]JENNA L COLLIER,KRISTEN E PAUKEN,CATHERINE A A LEE,et al.Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice [J].Journal of Exp Med,2023,220(10):e20221920.
[36]JARED OSTMEYER,JASON Y PARK,MITCHELL S VON ITZSTEIN,et al.T-cell tolerant fraction as a predictor of immune-related adverse events[J].Journal of Immunother Cancer,2023,11(8):e006437.
[37]ALEXANDER X LOZANO,AADEL A CHAUDHURI,AISHWARYA NENE,et al.T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma [J].Nature Medicine,2022,28(2):353-362.
[38]JING Y,LIU J,YE YQ,et al.Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy [J].Nature Communications,2020,11(1):4946.
[39]CHIAKI KURIMOTO,HIDEFUMI INABA,HIROYUKI ARIYASU,et al.Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors [J].Cancer Science,2020,111(5):1468-1477.
[40]SALAHALDIN A TAHIR,GAO JJ,YUJI MIURA,et al.Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities [J].Proceedings of the National Academy of Sciences,2019,116(44):22246-22251.
[41]AMANDA LEITER,SACHA GNJATIC,MARY FOWKES,et al.A common pituitary autoantibody in two patients with immune checkpoint inhibitor-mediated hypophysitis:zcchc8[J].AACE Clinical Case Reports,2020,6(4):e151-e160.
[42]PRADNYA D PATIL,MAURICIO BUROTTO,VAMSIDHAR VELCHETI.Biomarkers for immune-related toxicities of checkpoint inhibitors:current progress and the road ahead [J].Expert Review of Molecular Diagnostics,2018,18(3):297-305.
[43]PHILIP FRIEDLANDER,KEVIN WOOD,KARL WASMANN,et al.A whole-blood RNA transcript-based gene signature is associated with the development of CTLA-4 blockade-related diarrhea in patients with advanced melanoma treated with the checkpoint inhibitor tremelimumab [J].Journal for Immunother Cancer,2018,6(1):90.
[44]MARCUS WLFFER,FLORIAN BATTKE,MARTIN SCHULZE,et al.Biomarkers Associated with Immune-Related Adverse Events under Checkpoint Inhibitors in Metastatic Melanoma [J].Cancers,2022,14(2):302.
[45]AFAF ABED,NGIE LAW,LESLIE CALAPRE,et al.Human leucocyte antigen genotype association with the development of immune-related adverse events in patients with non-small cell lung cancer treated with single agent immunotherapy [J].European Journal of Cancer,2022,172:98-106.
[46]OMAR HASAN ALI,FIAMMA BERNER,DAVID BOMZE,et al.Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors [J].European Journal of Cancer,2019,107:8-14.
[47]LAURA C CAPPELLI,MEHMET T DORAK,MARIA P BETTINOTTI,et al.Association of HLA-DRB1 shared epitope alleles and immune checkpoint inhibitor-induced inflammatory arthritis [J].Rheumatology (Oxford),2019,58(3):476-480.
[48]ANGELIKI M STAMATOULI,ZOE QUANDT,ANA LUISA PERDIGOTO,et al.Collateral damage:insulin-dependent diabetes induced with checkpoint inhibitors[J].Diabetes,2018,67(8):1471-1480.
[49]GUAN YP,WANG J.Difficulty in oxicity management of tumor immunotherapy [J].Journal of Practical Oncology,2022,(06):490-494.
[50]ZHOU CC,WANG J,BU H,et al.Expert consensus on immune checkpoint inhibitor therapy for non-small cell lung cancer in China[J].Chinese Journal of Lung Cancer,2020,(02):65-76.
[51]CHRISTOPHER CLUXTON, JARUSHKA NAIDOO.Prospective clinical trials to advance the study of immune checkpoint inhibitor toxicity [J].Curr Oncol,2023,30(7):6862-6871.
[52]CHEN MT,MA LL,YU HQ,et al.JK5G postbiotics attenuate immune-related adverse events in NSCLC patients by regulating gut microbiota:a randomized controlled trial in China [J].Front Oncol,2023,13:1155592.

Memo

Memo:
National Natural Science Foundation of China(No.81873249);国家自然科学基金(编号:81873249);山东省自然科学基金资助项目(编号:ZR2020MH251)
Last Update: 2024-01-30