|Table of Contents|

Expression and clinical significance of TNFAIP3 in clear cell renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1094-1098
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of TNFAIP3 in clear cell renal cell carcinoma
Author(s):
ZHOU Caiting1; 2; HAN Wei1; 2; MA Yijun1; 2; DING Dong1; QI Tingyue3; YANG Yan3; WANG Lei1
1.Department of Pathology；3.Department of Ultrasound,Affiliated Hospital of Yangzhou University,Jiangsu Yangzhou 225009,China;2.Graduate School of Dalian Medical University,Liaoning Dalian 116044,China.
Keywords:
TNFAIP3; clear cell renal cell carcinoma; biomarker; prognosis assessment
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2023.06.021
Abstract:
Objective：To investigate the expression of TNFAIP3 in clear cell renal cell carcinoma (ccRCC),and to analyze the correlation between TNFAIP3 expression and clinicopathological features of patients.Method:The GEPIA2 was used to analyze the differential expression of TNFAIP3 in ccRCC tissues and normal kidney tissues,with complete clinical information collection ccRCC group 97 cases and the corresponding tissue adjacent to carcinoma 97 cases.Immunohistochemistry EnVision two-step method was used to detect the expression of TNFAIP3 in ccRCC tissues and corresponding adjacent normal kidney tissues,and analyze the expression of TNFAIP3 with patients' age,gender,WHO/ISUP grades,maximum tumor diameter,TNM staging and the relationship between the clinical pathological characteristics.Results:GEPIA2 analysis showed that compared with normal kidney tissue,TNFAIP3 was highly expressed in ccRCC tissue (P＜0.05),but the overall survival and disease-free survival of ccRCC patients with high TNFAIP3 expression were significantly higher than those of ccRCC patients with low TNFAIP3 expression (P＜0.05).Immunohistochemical detection of TNFAIP3 confirmed that TNFAIP3 was expressed in the cell membrane and cytoplasm from light yellow to brown in ccRCC tissues,and the proportion of high expression in ccRCC tissue is significantly higher than that in adjacent normal kidney tissue (P＜0.05).The expression level of TNFAIP3 is related to the WHO/ISUP renal cell carcinoma grade,maximum tumor diameter,TNM stage,and clinical parameters of lymph node metastasis in ccRCC tissues (P＜0.05).The high expression of TNFAIP3 indicates a better prognosis.Conclusion:The expression of TNFAIP3 in ccRCC tissues was significantly increased,but the overall survival and disease-free survival of ccRCC patients with high TNFAIP3 expression were better than those of ccRCC patients with low TNFAIP3 expression.However,the role and molecular regulation mechanism of TNFAIP3 involved in the proliferation and metastasis of ccRCC needs to be further studied.

References:

［1］ LJUNGBERG B,ALBIGES L,ABU-GHANEM Y,et al.European association of urology guidelines on renal cell carcinoma:The 2019 update［J］.European Urology,2019,75(5):799-810.
［2］ 日西丹·艾买提,艾尼瓦尔·艾木都拉,艾克拜尔·艾尼瓦尔,等.PPARα在肾透明细胞癌组织中的表达及其与预后的关系［J］.现代肿瘤医学,2022,30(07):1238-1243. RIXIDAN·AIMAITI,AINIWAER·AIMUDULA,AIKEBAIER·AINIWAER,et al.Expression of PPARα in renal clear cell carcinoma and its relationship with prognosis［J］.Modern Oncology,2022,30(07):1238-1243.
［3］ MOTZER RJ,JONASCH E,BOYLE S,et al.NCCN guidelines insights:Kidney cancer,version 1.2021［J］.Journal of the National Comprehensive Cancer Network,2020,18(9):1309-1315.
［4］SIEGEL RL,MILLER KD,FUCHS HE,et al.Cancer statistics,2021［J］.A Cancer Journal for Clinicians,2021,71(1):7-33.
［5］ MARTENS A,VAN LOO G.A20 at the crossroads of cell death,inflammationand autoimmunity［J］.Cold Spring Harbor Perspectives in Biology,2020,12(1):1-18.
［6］ POTTETI HR,VENKAREDDY LK,NOONE PM,et al.Nrf2 regulates anti-inflammatory A20 deubiquitinase induction by LPS in macrophages in contextual manner［J］.Antioxidants (Basel),2021,10(6):1-12.
［7］ SHEMBADE N,MA A,HARHAJ EW.Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes［J］.Science,2010,327(5969):1135-1139.
［8］ BOONE DL,TURER EE,LEE EG,et al.The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses［J］.Nature Immunology,2004,5(10):1052-1060.
［9］ PERAZZIO SF,ALLENSPACH EJ,EKLUND KK,et al.Behet disease (BD) and BD-like clinical phenotypes:NF-κB pathway in mucosal ulcerating diseases［J］.Scandinavian Journal of Immunology,2020,92(5):1-14.
［10］ 陈千.NF-κB信号通路中调控蛋白A20与ABIN1在弓形虫诱导人白血病T细胞株增殖和凋亡的作用机制［D］.广东:暨南大学,2018. CHEN Q.The functionary mechanism of A20 and ABIN1 in the NF-κB signaling pathway on the proliferation and apoptosis of human leukemia T cell induced by Toxoplasma gondii［D］.Guangdong:Jinan University,2018.
［11］ ROTHSCHILD DE,MCDANIEL DK,RINGEL-SCAIA VM,et al.Modulating inflammation through the negative regulation of NF-κB signaling ［J］.Journal of Leukocyte Biology,2018,103(6):1-20.
［12］ 张悦琪,廖晓辉.B细胞与狼疮肾炎治疗进展［J］.临床肾脏病杂志,2019,19(2):148-151,156. ZHANG YQ,LIAO XH.B cells and treatment progression in lupus nephritis［J］.Journal of Clinical Nephrology,2019,19(2):148-151,156.
［13］KATO M,SANADA M,KATO I,et al.Frequent inactivation of A20 in B-cell lymphomas［J］.Nature,2009,459(7247):712-716.
［14］BOCCHETTI M,FERRARO MG,RICCIARDIELLO F,et al.The role of microRNAs in development of colitis-associated colorectal cancer［J］.International Journal of Molecular Sciences,2021,22(8):1-15.
［15］SHEN LJ,SUN HW,CHAI YY,et al.The disassociation of the A20/HSP90 complex via downregulation of HSP90 restores the effect of A20 enhancing the sensitivity of hepatocellular Carcinoma cells to molecular targeted agents［J］.Frontiers in Oncology,2021,11:1-12.
［16］LEE E,OUZOUNOVA M,PIRANLIOGLU R,et al.The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20［J］.Oncogene,2019,38(4):469-482.
［17］DU B,LIU M,LI C,et al.The potential role of TNFAIP3 in malignant transformation of gastric carcinoma［J］.Pathology,Research and Practice,2019,215(8):1-12.
［18］杨慧敏,段秀枝,沈默,等.TNFAIP3在尿路上皮乳头状癌组织中的表达与临床意义［C］.浙江:2012年浙江省检验医学学术年会论文集,2012:325. YANG HM,DUAN XZ,SHEN M,et al.Expression and clinical significance of TNFAIP3 in urothelial papillary carcinoma［C］.Zhejiang:Proceedings of the 2012 Zhejiang Provincial Laboratory Medicine Annual Conference,2012:325.
［19］JAMES D BRIERLEY,MARY K GOSPODAROWICZ,CHRISTIAN WITTEKIND.TNM classification of malignant tumours,8th edition［M］.USA:John Wiley & Sons,Inc,2016:114-115.
［20］DELAHUNT B,CHEVILLE JC,MARTIGNONI G,et al.The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters［J］.The American Journal of Surgical Pathology,2013,37(10):1490-1504.
［21］ 张冬冬,顾生玖,杜云龙,等.乳腺癌组织中肿瘤相关巨噬细胞的浸润与血管内皮生长因子表达的相关性［J］.肿瘤研究与临床,2018,30(10):670-673,677. ZHANG DD,GU SJ,DU YL,et al.Correlation between tumor-associated macrophage infiltration and vascular endothelial growth factor expression in breast cancer tissues［J］.Cancer Research and Clinical,2018,30(10):670-673,677.
［22］LJUNGBERG B,ALBIGES L,ABU-GHANEM Y,et al.European association of urology guidelines on renal cell carcinoma:The 2019 update［J］.European Urology,2019,75(5):799-810.
［23］ZHANG T,MA C,ZHANG Z,et al.NF-κB signaling in inflammation and cancer［J］.MedComm (2020),2021,2(4):618-653.
［24］GUI D,DONG Z,PENG W,et al.Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-κB pathway inactivation［J］.Cancer Medicine,2021,10(11):3674-3688.
［25］KUNTER U,DANIEL S,ARVELO MB,et al.Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells［J］.Kidney International,2005,68(4):1520-1532.
［26］李强,熊咏民.A20基因与NF-κB信号通路的研究进展［J］.国外医学(医学地理分册),2019,40(1):87-89. LI Q,XIONG YM.Research progress of A20 gene and NF-κB signaling pathway［J］.Foreign Medical Sciences (Section of Medgeography),2019,40(1):87-89.

Memo

Memo:
江苏省卫生健康委医学科研项目指导性项目（编号：Z2019046）；江苏省扬州市科技局国际科技合作项目（编号：YZ2020200）
Last Update: 1900-01-01