|Table of Contents|

The value of shear wave elastography in quantitative assessment of tissue hardness around mass in the diagnosis of benign and malignant breast tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1099-1103
Research Field:
Publishing date:

Info

Title:
The value of shear wave elastography in quantitative assessment of tissue hardness around mass in the diagnosis of benign and malignant breast tumors
Author(s):
WANG Hua1; ZHU Yanbing2; DING Yunjie1; CAO Ying1; ZHANG Qi1; SUN Lei1; LI Xiaopeng1
1.The Second Affiliated Hospital of Xi＇an Jiaotong University，Shaanxi Xi＇an 710004，China；2.Shaanxi Pharmaceutical Holding Group Co.,Ltd，Shaanxi Xi＇an 710075,China.
Keywords:
shear wave elastography(SWE); breast tissue surrounding the mass; BI-RADS classification
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2023.06.022
Abstract:
Objective:To investigate the application value of shear wave elastography in quantitative assessment of tissue hardness around mass in the diagnosis of benign and malignant breast tumors．Methods:A total of 141 patients with breast tumors confirmed by surgical and pathological results from July 2019 to June 2022 were collected,including 152 masses,66 benign masses and 86 malignant masses.BI-RADS classification was performed and the elastic modulus values of mass and surounding tissues with 1 mm,2 mm and 3 mm were measured（Emax,Emean,Esd,Emin,SEmax1,SEmean1,SEsd1,SEmin1,SEmax2,SEmean2,SEsd2,SEmin2,SEmax3,SEmean3,SEsd3,SEmin3）,to compare the differences among 16 groups of parameters of benign and malignant masses and their surrounding tissues.Taking pathological diagnosis as the gold standard,the receiver operating characteristic (ROC) curve was drawn,and the area under the curve (AUC) of each parameter was compared to obtain the parameter with the greatest diagnostic value.Results:The elastic modulus values of benign and malignant breast masses and their surrounding tissues were statistically significant.Emax,Emean and Esd values of malignant breast masses were higher than benign ones,and Emin malignant breast masses were lower than benign ones.The AUC values of Emax,SEmax1,SEmax2 and SEmax3 were all greater than 0.90.The AUC value of SEmax2 was 0.958,the cut-off value was more than 128.33 kPa,the sensitivity of diagnosis was 77.9%,the specificity was 85.0%,and the accuracy rate was 85.5%.Conclusion:The SEmax2 value in the tissue within 2 mm around benign and malignant breast mass has the highest diagnostic efficiency,and the sensitivity,specificity and accuracy of diagnosis are better than conventional ultrasound,which has good clinical application value.

References:

［1］CHO N,HAN W,HAN BK,et al.Breast cancer screening with mammography plus ultrasonography or magnetic resonance imagine in women 50 years or younger at diagnosis and treated with breast conservation therapy［J］.JAMA Oncol,2017,3(11):1495-1502.
［2］薛剑桥,王旭婕,詹晓丽,等.三维剪切波弹性成像鉴别诊断乳腺良恶性结节的应用价值［J］.中华超声医学影像学杂志,2022,31(5):427-434. XUE JQ,WANG XJ,ZHAN XL,et al.Application of three-dimensional shear wave elastography in the differential diagnosis of benign and malignant breast masses［J］.Chinese Journal of Ultrasonography,2022,31(5):427-434.
［3］陈言,丁洁,杨蕊.应变式弹性成像与剪切波弹性成像在乳腺肿块良恶性判断中的应用价值研究［J］.中国实验诊断学,2022,26(4):484-487. CHEN Y,DING J,YANG R.Study on the application value of strain elastography and shear wave elastography in the determination of benign and malignant breast masses［J］.Chinese Journal of Laboratory Diagnosis,2022,26(4):484-487.
［4］何楠，丁中.超声新技术在乳腺良恶性肿块鉴别诊断中的研究进展［J］.医学综述，2018，24（23）：4736-4740. HE N,DING Z.Research progress of new ultrasound technique in differential diagnosis of benign and malignant breast lesions［J］.Medical Recapitulate,2018，24（23）：4736-4740.
［5］宋丽君,张家君,卢川.乳腺影像报告与数据系统临床应用进展［J］.中国医学影像技术,2017,33(11):1728-1731. SONG LJ,ZHANG JJ,LU C.Clinical applications of breast imaging reporting and data system［J］.Chinese Journal of Medical Imaging Technology,2017,33(11):1728-1731.
［6］戚敏,姜学忠,李嘉,等.剪切波弹性成像联合 CEUS校正乳腺影像报告和数据系统3～5类乳腺病变［J］.中国医学影像技术,2018,34(10):1509-1513. QI M,JIANG XZ,LI J,et al.Combination of shear wave elastography and CEUS in correction of BI-RADS classification 3-5 grade breast lesions［J］.Chinese Journal of Medical Imaging Technology,2018,34(10):1509-1513.
［7］刘健,武敬平,王宁,等.弹性应变率比值联合乳腺超声影像报告和数据系统诊断乳腺结节的应用价值［J］.中国医学科学院院报,2021,43(1):63-68. LIU J,WU JP,WANG N,et al.Application value of elastic strain rate ratio combined with breast ultrasound image report and data system in diagnosis of breast nodules［J］.Acta Academiae Medicinae Sinicae,2021,43(1):63-68.
［8］田阳，李良子.超声弹性成像评分法、硬环征、直方图分析鉴别乳腺肿块良恶性的诊断价值比较［J］.临床超声医学杂志,2020,22(5):340-343. TIAN Y,LI LZ.Diagnostic value of ultrasound elastography,stiff ring sign and histogram analysis in differentiating benign and malignant breast masses［J］.Journal of Clinical Ultrasound in Medicine,2020,22(5):340-343.
［9］XUE XW,LI JL,WAN WB,et al.Molecular mechanisms of breast nodule stiffness［J］.Acta Academiae Medicinae Sinicae,2018,40(2):279-283.
［10］SHI XQ,LI J,QIAN L,et al.Correlation between elastic parametwers and collagen fibre feature in breast lesions［J］ .Clin Radiol,2018,73(6):e591-e595.
［11］GUO R,LU G,QIN B,et al.Ultrasound imaging technologies for breast cancer detection and management:a review［J］.Ultrasound Med Biol,2018,44(1):37-70.
［12］LEE EJ,JUNG HK,KO KH,et al.Diagnostic performances of shear wave elastography:which parameter to use in differential diagnosis of solid breast masses［J］.Eur Radiol,2013,23(7):1803-1811.
［13］冯卉,李俊来,黄炎,等.剪切波弹性模量在乳腺病灶良恶性诊断中的应用价值［J］.中华超声影像学杂志，2013,22(3):235-238. FENG H,LI JL,HUANG Y,et al.Value of the shear wave elasticity in the diagnosis of benign and malignant breast lesions［J］.Chinese Journal of Ultrasonography,2013,22(3):235-238.
［14］周玮珺,吴媛媛,吴芳芳,等.声触诊弹性成像定量定性评价瘤旁组织硬度对乳腺肿瘤的诊断价值［J］.中国超声医学杂志,2020,36(8):695-698. ZHOU WJ,WU YY,WU FF,et al.Quantitative and qualitative evaluation of peritumoral tissue stiffness by sound touch elastography in the diagnosis of breast lesions［J］.Chinese J Ultrasound Med,2020,36(8):695-698.
［15］HUANG LD,MA MK,QUAN ZD,et al.Quantitative evaluation of tissue stiffness around lesion by sound touch elastography in the diagnosis of benign and malignant breast lesions［J］.PLoS One,2019,14(7):e0219943.
［16］叶磊,汪林,刘卫勇,等.定量分析周围区域弹性硬度在评估乳腺病灶良恶性中的价值［J］.安徽医学,2021,42(2):124-127. YE L,WANG L,LIU WY,et al.The diagnostic value of evaluation of the surrounding hardness by using shear elastography in breast lesions［J］.Anhui Medical Journal,20121,42(2):124-127.
［17］SCIMECA M,URBANO N,BONFIGLIO R,et al.Novel insights into breast cancer progression and metastasis:a multidisciplinary opportunity to transition from biology to clinical oncology［J］.Biochim Biophys Acta Rev Cancer,2019,1872(1):138-148.

Memo

Memo:
陕西省重点研发项目一般项目(编号：2020SF-057）
Last Update: 1900-01-01