|Table of Contents|

Research progress of 14-3-3ζ regulation of tumor-related signaling pathways

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
547-551
Research Field:
Publishing date:

Info

Title:
Research progress of 14-3-3ζ regulation of tumor-related signaling pathways
Author(s):
LIU Xin1; LU Hailing1; 2
1.Department of Internal Medical Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;2.Department of Oncology,the First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
14-3-3ζ; tumor; signaling pathway; pathogenesis
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.03.031
Abstract:
With the continuous research in the field of molecular biology,the occurrence of tumors is often accompanied by the activation of abnormal signaling pathways.14-3-3ζ is a subtype of 14-3-3 protein family.In recent years,it has been found that 14-3-3ζ can regulate multiple tumor-related signaling pathways to promote tumor progression.It is classified according to the mechanism of action,mainly including the regulation of NF-κB signaling pathway,PI3K/AKT signaling pathway,JAK-STAT signaling pathway,TGF-β signaling pathway,Wnt signaling pathway,Hippo signaling pathway,etc.14-3-3ζ can promote the proliferation and invasion of cancer cells,induce apoptosis,increase glycolysis,regulate tumor inflammation and immunity by regulating the above signaling pathways,thereby promoting tumorigenesis and development.Therefore,the molecular mechanism by which 14-3-3ζ affects tumor-related signaling pathways may be particularly important for the diagnosis and treatment of tumors.This article will focus on the research progress on the regulation of 14-3-3ζ on the signaling pathway of malignant tumors,in order to provide new ideas and directions for the in-depth study of tumor pathogenesis and the development of targeted drugs.

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Memo

Memo:
国家癌症中心攀登基金（编号：NCC201808B018）;哈医大一院科研创新基金（编号：2021M15）;北京医学奖励基金会课题研究项目（编号：YXJL-2021-0678-0664）
Last Update: 1900-01-01