|Table of Contents|

Clinical analysis and prognosis of children with extracranial malignant germ cell tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
535-539
Research Field:
Publishing date:

Info

Title:
Clinical analysis and prognosis of children with extracranial malignant germ cell tumors
Author(s):
JIAO Yangyang; FU Pan; JIANG Shayi; LIAO Xuelian; SHAO Jingbo; YANG Jingwei
Department of Hematology and Oncology,Shanghai Children‘s Hospital,Shang Hai Jiao Tong University,Shanghai 200062,China.
Keywords:
child; extracranial malignant germ cell tumor; prognosis
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.03.028
Abstract:
Objective:To summarize the clinical features and prognosis of extracranial malignant germ cell tumor in children.Methods:A retrospective analysis was performed on 49 cases with extracranial malignant germ cell tumor in our hospital from January 2015 to December 2019.Results:Totally 49 patients were included in the study,including 29 males and 20 females,with a median age of 20 months.42 cases were <4 years old,4 cases were between 4 and 11 years old,3 cases were >11 years old.The primary tumor were located at gonad in 30 cases (22 cases in testis,8 cases in ovary) and extragonadal sites in 19 cases (2 cases in mediastinum,1 case in enterocoelia,4 cases in pelvic cavity,4 cases in vagina,and 8 cases in sacrococcygeal region).6 cases were in stage I,16 cases in stage II,14 cases in stage III,and 13 cases in stage IV.6 cases were at low risk,24 cases at intermediate risk,and 19 cases at high risk.31 cases were yolk sac tumor,12 cases were malignant teratoma,and 6 cases were mixed germ cell tumor.All patients were treated with chemotherapy and surgical treatment,some with radiotherapy.The median follow-up time was 49 months,complete remission in 44 cases,partial response in 1 case,recurrence or progression in 4 cases.The 2-year OS rate and EFS rate were (98.0±2.0)% and (93.9±3.4)%.The 5-year OS rate and EFS rate were (95.6±3.1)% and (91.7±4.0)%,respectively.Conclusion:Chemotherapy with platinum-based obtained a positive effect in children with extracranial MGCT.AFP≥10 000 ng/mL,age>11 years old were the factors of poor prognosis patients with tumor.Progression can be treated by second-line conventional chemotherapy (SLCT),high dose of chemotherapy (HDCT),autologous stem cell transplantation (ASCT) and radiotherapy.

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上海市科委自然基金项目（编号：19ZR1442400）
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