|Table of Contents|

Research advances of apoptosis pathway and therapeutic inducers in ovarian cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
164-168
Research Field:
Publishing date:

Info

Title:
Research advances of apoptosis pathway and therapeutic inducers in ovarian cancer
Author(s):
WANG Xu1WANG Keyao1CHEN Han1LIU Jinhan1HUANG Chengri2
1.Medical College of Yanbian University,Jilin Yanbian 133000,China;2.Department of Gynecology,Affiliated Hospital of Yanbian University,Jilin Yanbian 133000,China.
Keywords:
ovarian cancerplatinum resistanceapoptosis signal pathwayapoptosis proteins
PACS:
R737.31
DOI:
10.3969/j.issn.1672-4992.2023.01.031
Abstract:
Ovarian cancer(OC) has the highest mortality rate among the malignant tumors of female reproductive system,which seriously threatens women's health.At present,platinum-based chemotherapy is the most commonly used chemotherapy regimen in malignancies of female reproductive system.However,many ovarian cancers are clinically resistant to platinum-based chemotherapy,which seriously affects the clinical efficacy.Therefore,the study of resistance to platinum in ovarian cancer cells has great significance to the treatment of ovarian cancer.Previous studies have found that the anti-apoptotic ability of ovarian cancer cells is an important factor leading to the resistance.This review presents the apoptotic pathways(JAK2/STAT3,Wnt/β-catenin,MET/HGF,MAPK/ERK,PI3K/AKT/mTOR) and their related therapeutic inducers in ovarian cancer,which in order to provide theoretical basis for subsequent researches.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81360382);国家自然科学基金项目(编号:81360382);吉林省教育厅“十三五”科学技术项目(编号:JJKH20191118KJ)
Last Update: 2022-11-30