|Table of Contents|

Research progress of acetyl coenzyme A metabolism in tumorepigenetic regulation

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
168-173
Research Field:
Publishing date:

Info

Title:
Research progress of acetyl coenzyme A metabolism in tumorepigenetic regulation
Author(s):
YANG Tong1; LIU Jin1; ZHOU Qian1; LI Bo1; 2
1.College of Life Science and Technology,Jinan University,Guangdong Guangzhou 510632,China;2.Institute of Chinese Medicinal Sciences,Guangdong Pharmaceutical University,Guangdong Guangzhou 510006,China.
Keywords:
tumor; acetyl-CoA; acetate; metabolic reprogramming; epigeneticalterations
PACS:
R73
DOI:
10.3969/j.issn.1672-4992.2023.01.032
Abstract:
Acetyl-CoA metabolism is reprogrammed in the process of tumorigenesis,which provides anabolic materials for the rapid growth of tumors.Recent research results have confirmed that intracellular acetyl-CoA can also confer tumor signal transduction by mediating histone acetylation modification.On that basis,the article will review the metabolic function of acetyl-CoA and the mechanisms of epigenetic regulation in tumors from the following three aspects:The summary of the source and function of acetyl-CoA.Brief introduction of the relationship between acetyl-CoA and acetate metabolism in tumors.Overview of the latest research progress about the mechanisms of acetyl-CoA metabolic regulating histone acetylation in tumor,that lead to epigenetic changes in the tumor,and then clarify the development of inhibitors targeting the key enzyme of acetyl-CoA in cancer.

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Memo

Memo:
中国博士后科学基金（编号：2019M653286）
Last Update: 2022-11-30