|Table of Contents|

Clinicopathological characteristics analysis of angiomyofibroblastoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1009-1012
Research Field:
Publishing date:

Info

Title:
Clinicopathological characteristics analysis of angiomyofibroblastoma
Author(s):
HUO Yuanyuan1; HAO Xiangyun1; ZHANG Taotao1; JING Caiping1; LI Xiaofeng2; CAO Peilong2; YUAN Li3
1.Department of Pathology,Yan'an People's Hospital,Shaanxi Yan'an 716000,China;2.Department of Pathology,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;3.Xi'an Beihuan Hospital,Shaanxi Xi'an 710032,China.
Keywords:
angiomyofibroblastoma; vulva; diagnosis and differential diagnosis; immunohistochemistry
PACS:
R737.35
DOI:
10.3969/j.issn.1672-4992.2021.06.022
Abstract:
Objective:To investigate the clinicopathological characteristics,imaging features,treatments and prognosis of angiomyofibroblastoma (AMF).Methods:The clinical data of 5 cases of AMF diagnosed from 2015 to 2019 were retrospectively analyzed.The clinical features,pathomorphological characteristics and the results of immunohistochemistry were observed.Results:5 cases of AMF were all females in reproductive period.And the tumors were located in the vulva.The patients had no obvious clinical symptoms and no specificity in laboratory examination.Histologically，the tumors were all well circumscribed and had abundant small to medium sized thin-wall vessels.The tumors consisted of alternating loose and dense regions.The tumor cells in the dense area gathered around the vessels and arranged in cords or chains.The tumor cells in the loose area scattered in myxoid matrix.Immunohistochemically，the tumor cells were positive for Desmin,Vimentin,ER and PR,but negative for CD31,CD31,S100 and CKPan.Only one case was positive for SMA.Conclusion:AMF is a rare mesenchymal tumor that predominantly occurs in the vulval region of women in reproductive peroid.The accurate diagnosis is based on pathological biopsy and immunohistochemistry.Surgical excision is the main treatment method to make a fine prognosis.

References:

［1］KUMAN RJ,CARCANGIU ML,HERRINGTON CS,et al.WHO classification of tumours of female reproductive organs［M］.Lyon:IARC,2014:245.
[2]FLETCHER CD,TSANG WY,FISHER C,et al.Angiomyofibroblastoma of the vulva.A benign neoplasm distinct from aggressive angiomyxoma［J］.Am J Surg Pathol,1992,16(4):373-382.
[3]FUKUNAGA M,NOMURA K,MATSUMOTO K,et al.Vulval angiomyofibroblastoma.Clinicopathologic analysis of six cases［J］.Am J Clin Pathol,1997,107(1):45-51.
[4]HISAOKA M,KOUHO H,AOKI T,et al.Angiomyofibroblastoma of the vulva:a clinicopathologic study of seven cases［J］.Pathol Int,1995,45:487-492.
[5]NIELSEN GP,ROSENBERG AE,YONG RH,et al.Angiomyofibroblastoma of the vulva and vagina［J］.Mod Pathol,1996,9:284-291.
[6]LASKIN WB,FETSCH JF,TAVASSOLI FA.Angiomyofibroblastoma of the female genital tract:analysis of 17 cases including a lipomatous variant［J］.Hum Pathol,1997,28(9):1046-1055.
[7]WANG J,SHENG W,TU X,et al.Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract［J］.Chin Med J,2000,113:1036-1039.
[8]SIDDIQUI MT,KOVARIK P,CHEJFEC G.Angiomyofibroblastoma of the spermatic cord［J］.BR J Urol,1997,79:475-476.
[9]LASKIN WB,FETSCH JF,MOSTOFI FK.Angiomyofibroblastoma-like tumor of the male genital tract:analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma［J］.Am J Surg Pathol,1998,22(1):6-16.
[10]ITO M,YAMAOKA H,SANO K,et al.Angiomyofibroblastoma of the male inguinal region［J］.Arch Pathol Lab Med,2000,124:1679-1681.
[11]HLAING T,TSE G.Angiomyofibroblastoma of the male perineum:an unusual location for a rare lesion［J］.Int J Surg Pathol,2000,8:79-82.
[12]SHINTAKU M,NAITOU M,NAKASHIMA Y.Angiomyofibroblastoma-like tumor (lipomatous variant)of the inguinal region of a male patient［J］.Pathol Int,2002,52:619-622.
[13]XU HP,TAN AP,GAO YJ,et al.One case of AMF in child's abdominal cavity［J］.Chinese Journal of Medical Imaging Technology,2013,29（2）:225.
[14]WANG ZL,ZHANG GX,PAN CJ.One case of AMF in vastus intermedius muscles［J］.Journal of Clinical Radiology,2016,35（8）:1175-1176.
[15]WANG Y,CHEN R,LIU HT.One case of AMF in liver［J］.Chinese Imaging Journal of Integrated Traditional and Western Medicine,2018,16（3）:236-237.
[16]LI SH,LIU XY,LI YY,et al.Ultrasonographic manifestations and diagnosis of angiomyofibroblastoma in vulva［J］.Chinese Journal of Medical Imaging Technology,2018,34（1）:42-44.
[17]SHANG HY,HAN L,WANG YP,et al.Diagnosis and treatment of 10 cases of female genital angiomyofibroblastoma［J］.Journal of International Obstetrics and Gynecology,2018,45（3）:350-354.
[18]WANG HY,WANG Z,LI K,et al.Clinicopathological analysis of 5 cases of angiomyofibroblastoma［J］.Chinese Journal of Diagnostic Pathology,2010,17（4）:257-259.
[19]SIASSI RM,PAPADOPOULOS T,MATAEL KE.Metastasizing aggressive angiomyxoma［J］.N Engl J Med,1999,341:1772.
[20]BLANDAMURA S,CRUZ J,FAURE VERGARA L,et al.Aggressive angiomyxoma:a second case of metastasis with patient's death［J］.Hum Pathol,2003,34:1072-1074.
[21]WANG YF, QIAN HL,JIN HM.Local recurrent vaginal aggressive angiomyxoma misdiagnosed as cellular angiomyofibroblastoma:A case report［J］.Exp Ther Med,2016,11（5）:1893-1895.
[22]NIELSEN GP,YOUNG RH,DICKERSIN GR,et al.Angiomyofibroblastoma of the vulva with sarcomatous transformation("angiomyofibrosarcoma")［J］.Am J Surg Pathol,1997,21（9）:1104-1108.
[23]SONG S,RUDRA S,HASSELLE MD,et al.The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy［J］.Cancer,2013,119（2）:325-331.

Memo

Memo:
西安市科技计划项目［编号：2019115213YX007SF040(4)］
Last Update: 1900-01-01