|Table of Contents|

Difference analysis of gene expression profiles between classical and follicular variant papillary thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
907-912
Research Field:
Publishing date:

Info

Title:
Difference analysis of gene expression profiles between classical and follicular variant papillary thyroid carcinoma
Author(s):
ZENG Su; XIA Xiaotian; XU Peipei; YE Ziheng; GUO Minggao
Department of Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200233,China.
Keywords:
papillary thyroid carcinoma; subtype; bioinformatics; differentially expressed gene; extracellular matrix
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2021.06.001
Abstract:
Objective:To analyze the difference of gene expression profiles in classical variant（CPTC） and follicular variant (FVPTC) papillary thyroid carcinoma（PTC） and explore the effects of related differentially expressed genes(DEGs) on lymph node metastasis and prognosis.Methods:The gene expression profile datum of tumor and normal tissues of the two subtypes were obtained from the comprehensive gene expression database (GEO).R language was used to screen DEGs and draw heatmap according to significantly differented DEGs.Cytoscape software was applyed to biological function enrichment,signal pathway and key genes screening.UALCAN online website was used to analyze the function of core genes in PTC pathology,metastasis and prognosis.Results:A total of 81 DEGs were differently expressed both in the two subtypes,and 261 and 78 DEGs were only expressed in CPTC and FVPTC respectively.Tyrosine metabolism and p53 signal pathway functioned in CPTC,while tyrosine metabolism and PPAR signal pathway in FVPTC.Core extracellular matrix (ECM) genes were remarkably associated with lymph node metastasis and prognosis of PTC.Conclusion:There are both similarities and differences in DEGs and pathways between FVPTC and CPTC.ECM genes may be potential markers for distinguishing PTC subtypes and predicting lymph node metastasis and prognosis.

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Memo

Memo:
National Natural Science Foundation of China(No.81672373）；国家自然科学基金资助项目（编号：81672373）
Last Update: 1900-01-01