[1]Lin H,Vanden Esschert J,Liu C,et al.Systematic review of hepatocellular carcinoma in China and other regions[J].J Gastroenterol Hepatol,2011,26(1):28-35.
[2]YANG SM,ZHANG N.Research progress of hepatocellular carcinoma chemotherapy[J].Chinese Journal of New Drugs and Clinical Remedies,2015,34(2):93-98.[杨绍梅,张娜.肝癌治疗药物的研究进展[J].中国新药与临床杂志,2015,34(2):93-98.]
[3]PANG WR.Clinical observation of sorafenib in intermediate and advanced hepatocellular carcinoma[D].Nanning:Guangxi Medical University,2016.[盘文荣.索拉非尼治疗中晚期原发性肝癌的临床疗效观察[D].南宁:广西医科大学,2016.]
[4]YAO LC,YANG RJ.Current situation and future prospects of chemotherapy for hepatocellular carcinoma[J].Chin J Clin Hepatol,2005,21(1):62-64.[姚连昌,杨仁杰.原发性肝癌化疗用药的现状与展望[J].临床肝胆杂志,2005,21(1):62-64.]
[5]HUANG QR,ZHANG L.New advances in the treatment of primary hepatocellular carcinoma[J].Journal of Practical Medicine,2016,32(4):2275-2278.[黄乾荣,张玲.原发性肝癌治疗研究新进展[J].实用医学杂志,2016,32(4):2275-2278.]
[6]FArazi PA,Depinho RA.Hepatocellular carcinoma pathogenesis:From genes to environment[J].Nature Reviews Cancer,2006,6(9):674-687.
[7]Luk JM,Wang X,Liu P,et al.Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer:from laboratory discovery to clinical evaluation[J].Liver International,2007,27(7):879-890.
[8]MIAO L,MA SW,FAN GW,et al.Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity[J].Tianjin Journal of Traditional Chinese Medicine,2013,30(5):291-293.[苗琳,马尚伟,樊官伟,等.补骨脂酚拮抗AR转录活性抑制雄激素诱导的前列腺癌细胞LNCaP的增殖[J].天津中医药,2013,30(5):291-293.]
[9]WANG LM,ZUO YP.Effects of bakuchiol on proliferation,migration and apoptosis of oral squamous cell carcinoma and its underlying mechanisms[J].Journal of Shangxi University,2018,49(4):365-370.[王路明,左艳萍.补骨脂酚对口腔鳞状细胞癌增殖、迁移和凋亡的影响及其机制[J].山西医科大学学报,2018,49(4):365-370.]
[10]Chen Z,Jin K,Gao L,et al.Anti-tumor effects of bakuchiol,an analogue of resveratrol,on human lung adenocarcinoma A549 cell line[J].Eur J Pharmacol,2010,643(2-3):170-179.
[11]CHEN HL,FENG HJ,LI YC.In vitro antitumor activity and synthesis of the key intermediate of bakuchiol[J].Acta Pharmaceutica Sinica,2010,45(4):467-470.[陈红莉,冯慧瑾,李援朝.补骨脂酚的体外抗肿瘤活性及其关键中间体的合成研究[J].药学学报,2010,45 (4):467-470.]
[12]YU Y,WANG YJ,PI JX,et al.Research progress of bakuchiol[J].Journal of Shandong University of TCM,2013,37(2):174-177.[于悦,王亚静,皮佳鑫,等.补骨脂酚研究进展[J].山东中医药大学学报,2013,37(2):174-177.]
[13]NIE LJ,LI HM,GUO X,et al.Study on antioxidant and antitumor active ingredient from Psoralea corylifolia[J].Journal of Bengdu Medical College,2015,40(11):1461-1464.[聂丽娟,李红梅,郭星,等.补骨脂抗氧化及抗肿瘤活性成分的研究[J].蚌埠医学院学报,2015,40(11):1461-1464.]
[14]LU CX,HAN YH,XIN ZL,et al.Protective effects of bakuchiol on adriamycin-induced myocardial injury and potential mechanisms[J].Journal of Northwest University (Natural Science Edition),2018,48(6):769-775.[陆晨曦,韩跃虎,辛振龙,等.补骨脂酚对阿霉素心肌细胞损伤的保护作用及机制研究[J].西北大学学报(自然科学版),2018,48(6):769-775.]
[15]YANG SJ,ZHONG SD,YANG JP,et al.Optimization of extraction and purification process of bakuchiol and analysis of its effect on osteoporosis[J].Chinese Journal of Experimental Traditional Medical Formulae,2017,23(22):43-47.[杨胜杰,钟少达,杨进平,等.补骨脂酚的提取纯化工艺优选及其对骨质疏松症的治疗作用分析[J].中国实验方剂学杂志,2017,23(22):43-47.]
[16]MAO HP,NIU ZC,WANG XY,et al.Effects of bakuchiol on secretion of testosterone and estradiol from H295R cells in human with carcinoma of adrenal cortex[J].Journal of Tianjin University of Traditional Chinese Medicine,2014,33(6):347-350.[毛浩萍,牛子长,王兴业,等.补骨脂酚对人肾上腺皮质癌H295R细胞中睾酮和雌二醇分泌的影响[J].天津中医药大学学报,2014,33(6):347-350.]
[17]ZHANG N,NIU CY,XU HD,et al.The research of bakuchiol on melanin synthesis and its intervention of MAPK signaling pathway in human A375 cells[J].Shanghai Journal of Traditional Chinese Medicine,2016,50(1):79-82.[张宁,牛春影,徐红丹,等.补骨脂酚对人A375细胞黑素生成及MAPK信号通路干预作用研究[J].上海中医药杂志,2016,50(1):79-82.]
[18]ZHANG YS,LIU YQ,WU ZL,et al.Study on the toxic effect of bakuchiol on kidney in mice[J].Notification of traditional Chinese Medicine,1981(3):30-32.[张玉顺,刘玉琦,吴子伦,等.补骨脂酚对小鼠肾脏毒害作用的研究[J].中药通报,1981(3):30-32.]
[19]JIANG F,ZHOU XR,WANG Q,et al.Cytotoxic effect and mechanism of bakuchiol and bakuchiol combined with psoralen on HK-2 cell[J].Chinese Journal of Pharmacology and Toxicology,2010,24(1):50-58.[江芳,周昕睿,王旗,等.补骨脂酚及其与补骨脂素合用对HK-2细胞的毒性及其机制[J].中国药理学与毒理学杂志,2010,24(1):50-58.]
[20]ZHANG Y,YANG L,BI YN,et al.Experimental study on subchronic toxicity of psoralen in mice after oral administration for 4 weeks[J].Lishizhen Medicine and Materia Medica Research,2018,29(12):2838-2840.[张玥,杨莉,毕亚男,等.补骨脂酚口服4周小鼠亚慢性毒性试验研究[J].时珍国医国药,2018,29(12):2838-2840.]
[21]BI YN,LI Z,ZHOU K,et al.Influence of bakuchiol on liver function and bile acid transporters BSEP and NTCP in mouse[J].Journal of Tianjin University of Traditional Chinese Medicine,2015,34(4):222-225.[毕亚男,李震,周昆,等.补骨脂酚对小鼠肝功能和胆汁酸转运体BSEP、NTCP的影响[J].天津中医药大学学报,2015,34(4):222-225.]
[22]CHEN QY,YANG L,WANG YQ.Protective effect of bakuchiol on hepatic stellate cells induced by TGF-β[J].Chinese Journal of Experimental Traditional Medical Formulae,2018,24(16):131-135.[陈巧云,杨柳,王业秋,等.补骨脂酚对TGF-β诱导人肝星状细胞损伤的保护作用[J].中国实验方剂学杂志,2018,24(16):131-135.]
[23]CAO M.Effect of S-bakuchiol in psoralen on protecting liver in rats in vivo and in vitro[J].World Phytomedicines,2006,21(5):216.[曹玫.补骨脂中S-补骨脂酚对大鼠保肝作用的体内外实验[J].国外医药(植物药分册),2006,21(5):216.]
[24]ZHOU K,WANG AH,CHAI LJ,et al.Cytotoxicity of bakuchiol on HepG2 cells and effects on BSEP,NTCP,FXR and CYP7A1[J].J Toxicol,2015,29(3):193-196.[周昆,王安红,柴丽娟,等.补骨脂酚对HepG2的细胞毒性及BSEP、NTCP、FXR、CYP7A1的影响[J].毒理学杂志,2015,29(3):193-196.]
[25]Ondrouskova E,Vojtesek B.Programmed cell death in cancer cells[J].Klinicka Onkologie,2014,27(1):7-14.
[26]Madrid A,Cardile V,Gonzalez C,et al.Psoralea glandulosa as a potential source of anticancer agents for melanoma treatment[J].International Journal of Molecular Sciences,2015(16):7944-7959.
[27]Li L,Chen X,Liu CC,et al.Phytoestrogen bakuchiol exhibits in vitro and in vivo anti-breast cancer effects by inducing S phase arrest and apoptosis[J].Frontiers in Pharmacology,2016(7):128.
[28]Lin J,Yao HJ,Li RY.Bakuchiol inhibits cell proliferation and induces apoptosis and cell cycle arrest in SGC-7901 human gastric cancer cells[J].Biomedical Research,2016,27(1):181-185.
[29]XIAO G,YANG R,WU T,et al.Bakuchiol enhanced TRAIL induced HepG2 cell apoptosis through activating oxidative stress[J].Progress in Modern Biomedicine,2018,18(20):3835-3839,3853.[肖嘎,杨锐,吴涛,等.补骨脂酚通过激活ROS强化TRAIL的抗肝细胞癌HepG2细胞作用的机制研究[J].现代生物医学进展,2018,18(20):3835-3839,3853.]
[30]Lv L,Liu B.Anti-tumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways[J].Molecular Medicine Reports,2017,16(6):8977-8982.
[31]Park MH,Kim JH,Chung YH,et al.Bakuchiol sensitizes cancer cells to TRAIL through ROS-and JNK-mediated upregulation of death receptors and downregulation of survival proteins[J].Biochemical and Biophysical Research Communications,2016,473(2):586-592.
[32]CHEN Z.Anticancer activity and mechanism of natural and target-designed small molecule compounds on non-small cell lung cancer[D].Hangzhou:Zhejiang University,2010.[陈哲.天然及靶向设计小分子化合物抗非小细胞肺癌活性和机制研究[D].杭州:浙江大学,2010.]
[33]HUANG XJ,ZHOU XY,WEN YS.Simultaneous determination of bavachin and bakuchiol in Psorslea corylifolia by HPLC[J].China Pharmacy,2017,28(24):3400-3402.[黄晓婧,周晓英,文永盛.HPLC法同时测定补骨脂药材中补骨脂二氢黄酮和补骨脂酚的含量[J].中国药房,2017,28(24):3400-3402.]
[34]ZHANG ZY,ZHOU HL,MA L.Determination of bakuchiol in fruits of Psoralea Carylifolia by high-performance liquid chromatography[J].Clinical Medical & Engineering,2013,20(5):539-540.[张志宇,周海玲,马麟.高效液相色谱法测定补骨脂中补骨脂酚的含量[J].临床医学工程,2013,20(5):539-540.]
[35]LIU EW,WANG JL,HAN LF.Research on bakuchiol enriching method from Psoralea corylifolia L with maeroporous adsorptive resin D101[J].Journal of Tianjin University of Traditional Chinese Medicine,2012,31(2):95-97.[刘二伟,王家龙,韩立峰.D101大孔吸附树脂法富集补骨脂中补骨脂酚的研究[J].天津中医药大学学报,2012,31(2):95-97.]
[36]YAO ST,YANG B,XU ZL.Determination of bakuchiol in the fruit of Psoralea corylifolia L[J].China Journal of Chinese Materia Medica,1995,20(11):681-683,704.[姚三桃,杨滨,徐植灵.补骨脂中补骨脂酚的含量测定[J].中国中药杂志,1995,20(11):681-683,704.]
[37]GUO YH,ZHANG X.Proceedings of the symposium on improving the effectiveness of traditional Chinese medicine and quality control of Chinese herbal pieces[C].China Association of Chinese Medicine,2009:4.[郭晏华,张旭.中药药效提高与中药饮片质量控制交流研讨会论文集[C].中华中医药学会,2009:4.]
[38]ZHANG BY,CHAI X,WANG YF,et al.A simple and efficient method for preparation of bakuchiol[J].Tianjin Journal of Traditional Chinese Medicine,2016,33(4):245-247.[张波泳,柴欣,王跃飞,等.一种制备补骨脂酚的简单、高效的方法[J].天津中医药,2016,33(4):245-247.]
[39]Zhao Q.A study on the synthesis of bakuchiol,the analogues of the natural product Penicillide and the synthesis of (E)-Fluoroolefins[D].Shanghai:Fudan University,2013.
[40]Xu QQ.The study of a new synthetic procedure of Zolpodem and the first asymmetric total synthesis of natural product hydroxybakuchiol[D].Shanghai:Fudan University,2013.
[41]Huang SH,Huang MY,Jia XS,et al.Chemistry and biology of bakuchiol[J].Chinese Journal of Organic Chemistry,2014,34(12):2412-2423.
[42]GAO X,WANG YJ,PI JX,et al.Intestinal absorption kinetics of bakuchiol in rats[J].Chinese Traditional Patent Medicine,2013,35(10):2122-2125.[高旭,王亚静,皮佳鑫,等.补骨脂酚大鼠在体肠吸收动力学研究[J].中成药,2013,35(10):2122-2125.]
[43]DU XL.Structural modification and total synthesis of bakuchiol[D].Shanghai:Shanghai Institutes for Biological Sciences,2007.[杜小龙.补骨脂酚的结构修饰及全合成研究[D].上海:中国科学院上海药物研究所,2007.]
[44]GAO X,YU Y,WANG YJ,et al.Determination of equilibrium solubility and apparent oil/water partition coefficient of bakuchiol[J].West China Journal of Pharmaceutical Sciences,2013,28(3):285-286.[高旭,于悦,王亚静,等.补骨脂酚平衡溶解度和表观油水分配系数的测定[J].华西药学杂志,2013,28(3):285-286.]
[45]LI N,WANG YJ,ZHU GM,et al.Kinetics and effect of bacuchiol on tyrosinase activity[J].Chinese Journal of Experimental Traditional Medical Formulae,2017,23(1):30-33.[李娜,王亚静,朱光媚,等.补骨脂酚对酪氨酸酶活性的影响及动力学分析[J].中国实验方剂学杂志,2017,23(1):30-33.]