|Table of Contents|

Expression of Fibulin-3 in stage T1 non-muscle invasive bladder cancer and its correlation with tumor recurrence and progression

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
436-440
Research Field:
Publishing date:

Info

Title:
Expression of Fibulin-3 in stage T1 non-muscle invasive bladder cancer and its correlation with tumor recurrence and progression
Author(s):
Wang XuefengZhao Qi
Department of Urology,Nanyang First People's Hospital,Henan Nanyang 473000,China.
Keywords:
Fibulin-3stage T1 NMIBCtumor recurrenceprogression
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2020.03.018
Abstract:
Objective:To investigate the expression of Fibulin-3 in stage T1 non-muscle invasive bladder cancer (NMIBC) and its correlation with tumor recurrence and progression.Methods:34 cases of stage T1 NMIBC treated in the urinary surgery department of our hospital from January 2013 to December 2014 were selected,and the tumor tissues were collected for the detection of Fibulin-3 expression.Then the correlation of Fibulin-3 with clinicopathological features,recurrence and progression of bladder cancer was analyzed.Results:Of 34 patients,Fibulin-3 was highly expressed in 22 cases and lowly expressed in 12 cases.The expression level of Fibulin-3 was positively correlated with tumor grade (P<0.05).8 patients had recurrence with a median recurrence time of 15 (4~48)months,and 5 patients had progress with a median progression time of 21(8~32)months during the follow-up period.Tumor grade and high expression of Fibulin-3 were associated with recurrence and progression,confirmed their role as influencing factors of tumor recurrence and progression (P<0.05).Kaplan-Meier curve of Fibulin-3 expression showed that patients with low expression of Fibulin-3 had a higher progression-free survival rate (P<0.05).Cox regression analysis showed that the single factors had statistic difference (P<0.05).Fibulin-3 high expression and tumor grade were independent risk factors for recurrence and progression of bladder cancer patients (P<0.05).Conclusion:Fibulin-3 overexpression is an independent prognostic factor for recurrence and progression of stage T1 NMIBC,so its detection can be used to predict recurrence and progression of bladder cancer and provide guidance for timely treatment.

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