|Table of Contents|

The successful treatment of 3 patients with POEMS syndrome with subcutaneously injected bortezomib based regimen and literature review

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
440-443
Research Field:
Publishing date:

Info

Title:
The successful treatment of 3 patients with POEMS syndrome with subcutaneously injected bortezomib based regimen and literature review
Author(s):
Yuan RuifengZong ChuntaoCao ChunYang LijieBai Qingxian
Department of Hematology,the First Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710032,China.
Keywords:
POEMS syndromebortezomibsubcutaneous injectionweekly plan
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2020.03.019
Abstract:
Objective:To explore the effectiveness and safety of bortezomib based regimen in the treatment of POEMS syndrome.Methods:The process and results of 3 patients with POEMS syndrome treated with bortezomib based regimen were reported,and relevant literatures were reviewed.Results:After chemotherapy,one patient's neurological symptoms were significantly improved,one patient's abdominal distension disappeared,and one patient's neurological symptoms,chest tightness and shortness of breath were improved.Conclusion:The bortezomib regimen was effective in the treatment of POEMS syndrome without neurotoxic side effects.

References:

[1]Dispenzieri A,Kyle RA,Lacy MQ,et al.POEMS syndrome:Definitions and long-term outcome[J].Blood,2003,101(7):2496-2506.
[2]ZHU Weiguo,WANG Yu,ZENG Xuejun,et al.A clinical analysis of 32 cases of POEMS syndrome[J].Chin J Intern Med,2006,45(2):108-111.[朱卫国,王玉,增学军,等.POEMS综合征32例临床分析[J].中华内科杂志,2006,45(2):108-111.]
[3]Dispenzieri A.POEMS syndrome:2017 update on diagnosis,risk stratification,and management[J].Am J Hematol,2017,92(8):814-829.
[4]Dispenzieri A.POEMS syndrome[J].Hematology,2007,21(6):285-299.
[5]Jian L,Dao-bin Z.New advanced in the diagnosis and treatment of POEMS syndrome[J].Bri J Haemato,2013,161(9):303-315.
[6]Kourelis TV,Buadi FK,Kumar SK,et al.Long-term outcome of patients with POEMS syndrome:An update of the Mayo Clinic experience[J].Am J Hematol,2016,91(6):585-589.
[7]D' Souza A,Lacy M,Gertz M,et al.Long-term outcomes after autologous stem cell transplantation for patients witn POEMS syndrome(osteosclerotic myeloma):A single-center experience[J].Blood,2012,120(7):56-62.
[8]Blade J,Cibeira MT,Rosinol L.Bortezomib:Avaluable new antineoplastic strategy in multiple myeloma[J].Acta Oncol,2005,44(5):440-448.
[9]He H,Fu W,Du J,et al.Successful treatment of newly diagnosed POEMS syndrome with reduced-dose bortezomib based regimen[J].Br J Haematol,2018,181(1):122-151.
[10]Tang X,Shi X,Sun A,et al.Successful bortezomib-based treatment in POEMS syndrome[J].Eur J Haematol,2009,83(6):609-610.
[11]Ohguchi H,Ohba R,Onishi Y,et al.Successful treatment with bortezomib and thalidomide for POEMS syndrome[J].Ann Hematol,2011,90(9):1113-1114.
[12]Li Linghao,Zhang Ri,Tang Xiaowen,et al.A case of POEMS syndrome treated with bortezomib based chemotherapy combined with hematopoietic stem cell transplantation[J].Chin J Hematol,2011,32(11):733.
[13]Sobas MA,Alonso Vence N,Diaz Arias J,et al.Efficacy of bortezomib in refractory form of multicentric Castleman disease associated to poems syndrome(MCD-POEMS variant)[J].Ann Hematol,2010,89(2):217-219.
[14]Kaygusuz I,Tezcan H,Cetiner M,et al.Bortezomib:a new therapeutic option for POEMS syndrome[J].Eur J Haematol,2010,84(2):175-177.
[15]Warsame R,Kohut IE,Dispenzieri A.Successful use of cyclophosphamide,bortezomib,and dexamethasone to treat a case of relapsed POEMS[J].Eur J Haematol,2012,88(6):549-550.
[16]Wang X,Ye S,Xiong C,et al.Successful treatment with bortezomib and thalidomide for POEMS syndrome associated with multicentric mixed-type Castleman's disease[J].Jpn J Clin Oncol,2011,41(10):1221-1224.
[17]Li J,Zhang W,Kang WY,et al.Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy,organomegaly,endocrinopathy,M protein and skin changes syndrome complicated by renal failure[J].Leuk Lymphoma,2012,53(12):2527-2529.
[18]Zeng Ke,Liu Zhigang,Yang Quanrong,et al.Bottezomib subcutaneous injection combined with autologous hematopoietic stem cell transplantation for poems syndrome: a case report and literature review[J].Chin J Hematol,2013,34(6):550-552.
[19]Takehito Iwase,Hirotaka Yokouch,Sonoko Misawa,et al.Reduction of optic disc oedema by bortezomib and dexamethasone followed by autologous peripheral blood stem cell transplantation in patient with POEMS syndrome[J].Neuro-ophthalmology,2018,42(1):25-30.
[20]Yoshimi Ishii,Etsuko Yamazaki,Yasufumi Ishiyama,et al.Successful treatment of POEMS syndrome with bortezomib and dexamethasone,combined with radiotherapy,and followed by autologous stem cell transplantation[J].Int J Hematol,2013,98(6):723-728.
[21]Argyriou AA,Iconomou G,Kalofonos HP.Bortezomib-induced peripheral neuropathy in multiple myeloma:A comprehensive review of the literature[J].Blood,2008,112(5):1593-1599.
[22]Bringhen S,Larocca A,Rossi D,et al.Efficacy and safety of once-weekly bortezomib in multiple myeloma patients[J].Blood,2010,116(23):4745-4753.
[23]Moreau P,Coiteux V,Hulin C,et al.Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma[J].Haematologica,2008,93(12):1908-1911.

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陕西省自然科学基础研究计划(编号:2017JM8025)
Last Update: 1900-01-01