|Table of Contents|

The protection of Xihuang capsules against radiation-induced oral mucositis in rats

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
383-386
Research Field:
Publishing date:

Info

Title:
The protection of Xihuang capsules against radiation-induced oral mucositis in rats
Author(s):
Dong Kechen1Zhang Meng1Liang Yi1Peng Cong2Fei Xinxiong1
1.Department of Head and Neck Oncology;2.Department of Otolaryngology,Huangshi Central Hospital of Edong Healthcare,Hubei Huangshi 435000,China.
Keywords:
ratradiation-induced oral mucositisXihuang capsuleinterleukin-1β (IL-1β)tumor necrosis factor-α (TNF-α)protective effect
PACS:
R739.91
DOI:
10.3969/j.issn.1672-4992.2020.03.007
Abstract:
Objective:To investigate the protective effect and relative mechanism of Xihuang capsules on radiation-induced oral mucositis in rats.Methods:Totally 54 female Wistar rats were randomly divided into administration group,irradiation alone group and blank control group.Except for the blank control group,the other two groups were modeled with a single dose of 30 Gy in 6 MV X-ray by Varian Trilogy.The administration group rats were given Xihuang suspension for continuous gastric perfusion from the 1st day to the 28th day after irradiation,while the irradiation alone group and the blank control group were given normal saline.The changes of buccal mucosa were evaluated daily after irradiation.The rats were sacrificed on the 3rd,14th and 28th day after irradiation to observe the pathological sections of buccal mucosa.After rats being sacrificed,the levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in serum were measured by ELISA,and IL-1β and TNF-α mRNA expression in buccal mucosa tissue were assayed by RT-PCR.Results:After Xihuang capsules treatment,the inflammatory reaction of buccal mucosal tissue was markedly decreased compared with irradation alone group.Furthermore,the serum levels of IL-1β and TNF-α were obviously reduced (P<0.05) and the IL-1β and TNF-α mRNA levels in buccal mucosal tissue were also decreased (P<0.05).Conclusion:Xihuang plays a mucoprotective role against radiation-induced oral mucositis in rats and the down-expression of IL-1β and TNF-α may be involved.

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Memo

Memo:
湖北省自然科学基金(编号:2013CFC060);黄石市科技攻关计划(编号:HSYL2016000023)
Last Update: 1900-01-01