|Table of Contents|

Expression mechanism of immunogenic cell death related molecules and regulation of immunity

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
316-320
Research Field:
Publishing date:

Info

Title:
Expression mechanism of immunogenic cell death related molecules and regulation of immunity
Author(s):
Yang Du; Tian Tongde; Yue Wenli
Chinese and Western Medicine Department,Affiliated Tumor Hospital of Zhengzhou University,Henan Zhengzhou 450008,China.
Keywords:
immunogenic cell death; calreticulin; adenosine triphosphate; heat shock protein; high mobility histone B1; tumor immunity
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2020.02.032
Abstract:
Studies have shown that tumors are treated with some chemicals and radiation，and immunogenic cell death（ICD) occurs in the tumor，followed by damage-associated molecular patterns（DAMPs) such as calreticulin（CRT)，adenosine triphosphate（ATP)，heat shock protein（HSP)，high mobility group protein B1（HMGB1) signaling molecules,whichreally enhance the immunogenicity of tumor cells，recruit dendritic cells(DC) to the tumor bed and enhance their functions that activate specific cytotoxic T lymphocytes（CTL) to attack tumors.ICD and its DAMPs provide new therapeutic basis and means for tumor treatment，monitoring the changes of tumor cell immunogenicity before and after chemotherapy，organically combining chemotherapy and immunotherapy，and improving the therapeutic effect of tumor.This article reviews the expression mechanism of ICD-related molecules and the regulation of immune system.

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Memo

Memo:
National Natural Science Foundation of China（No.81373879）;国家自然科学基金资助项目（编号：81373879）
Last Update: 2019-11-29