|Table of Contents|

Advances of CSN6 in tumor progression and treatment

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
320-326
Research Field:
Publishing date:

Info

Title:
Advances of CSN6 in tumor progression and treatment
Author(s):
Guan Xin123Liu Chao123Zhan Fei123Yao Yuanfei123Zhang Yanqiao123
1.Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;2.Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Harbin 150081,China;3.Heilongjiang Academy of Medical Science,Heilongjiang Harbin 150086,China.
Keywords:
CSN6ubiquitinationmalignant tumortherapy target
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2020.02.033
Abstract:
CSN6 is one of the subunits of the constitutive photomorphogenesis 9 signalsome(CSN),which is an important regulator of the ubiquitin-proteasome pathway.CSN6 is one subunit of the constitutive photomorphogenesis 9 signalosome(CSN),an evolutionarily conserved multiprotein complex found in plants and animals,which is necessary for the functuion of CSN.A growing number of studies have shown that CSN6 expression is elevated in multiple cancer types.Researchers have discovered that CSN6 plays a key regulatory role in the degradation of a variety of tumor-associated proteins and signal transduction,suggesting that CSN6 is associated with the development of tumors.Here,we summarized the expression and clinical significance of CSN6 in various neoplasms and concluded its relevant mechanisms involved in tumorigenesis and development to reveal its potential value in cancer therapy.

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Memo

Memo:
National Natural Science Foundation of China(No.81672428);国家自然科学基金资助项目(编号:81672428)
Last Update: 2019-11-29