|Table of Contents|

Research progress on gene polymorphisms related to osteosarcoma susceptibility

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
304-307
Research Field:
Publishing date:

Info

Title:
Research progress on gene polymorphisms related to osteosarcoma susceptibility
Author(s):
Nong Feng1Lan Changgong2Tang Yujin2
1.Graduate School of Youjiang Medical College for Nationalities,Guangxi Baise 533000,China;2.Department of Orthopedics,Affiliated Hospital of Youjiang Medical College for Nationalities,Guangxi Baise 533000,China.
Keywords:
osteosarcomasusceptibilitygenetic polymorphisms
PACS:
R738.1
DOI:
10.3969/j.issn.1672-4992.2017.02.039
Abstract:
Osteosarcoma is a primary malignant bone tumor in adolescents.It has taken place mostly on humeral metaphysis,proximal tibia and distal femur.Although the 5-year survival rate of patients with osteosarcoma was increased from 30% to 50%~70%,the morbidity and mortality of osteosarcoma is still very high in virtue of relapse and metastasis.A large number of studies have shown that the pathogenesis of osteosarcoma not only linked to the environmental factors,but also closely related to genetic factors.Gene polymorphism is an important component of genetic factors,which is involved in the occurrence and development of diseases.At present,there are many researches about the genetic polymorphisms of osteosarcoma,and some achievements have been made in its prevention,diagnosis,treatment and prognosis.This article reviews the research progress of related genetic polymorphisms in osteosarcoma susceptibility.

References:

[1]Li H,Min D,Zhao H,et al.The prognostic role of Ezrin immunoexpression in osteosarcoma:A Meta-analysis of published data[J].PLoS One,2013,8(6):e64513.
[2]Haddox CL,Han G.Osteosarcoma in pediatric patients and young adults:A single institution retrospective review of presentation,therapy,and outcome[J].Sarcoma,2014,2014:402509.
[3]Wafa H,Grimer RJ.Surgical options and outcomes in bone sarcoma[J].Expert Rev Anticancer Ther,2006,6:239-248.
[4]Goricar K,Kovac V,Jazbec J,et al.Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma[J].Pharmacogenet Genomics,2014,24:514-521.
[5]Yang J,Yang D,Sun Y,et al.Genetic amplification of the vascular endothelial growth factor(VEGF) pathway genes,including VEGFA,in human osteosarcoma[J].Cancer,2011,117(21):4925-4938.
[6]Andersen S,Donnem T,Al-Shibli K,et al.Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma:VEGF-A impact is strongly associated with Ang-2[J].PLoS One,2011,6:e19773.
[7]Zhang G,Bai R,Zhang T,et al.Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma[J].Genet Mol Res,2015,14(3):8283-8289.
[8]Liu JQ,Bai X,Duan DC,et al.Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients[J].Oncol Lett,2015,10(3):1481-1486.
[9]Wang Z,Wen P,Luo X,et al.Association of the vascular endothelial growth factor(VEGF) gene single-nucleotide polymorphisms with osteosarcoma susceptibility in a Chinese population[J].Tumour Biol,2015,35(4):3605-3610.
[10]Hu GL,Ma G,Ming JH.Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma[J].Genet Mol Res,2015,14(4):14561-14566.
[11]Ti Z,Bai R,Zhai Z,et al.Single nucleotide polymorphisms in VEGF gene are associated with an increased risk of osteosarcoma[J].Int J Clin Exp Pathol,2014,7(11):8143-8149.
[12]Li LZ,Lin W,Lei S,et al.Investigation on the role of VEGF gene polymorphisms in the risk of osteosarcoma[J].Pak J Med Sci,2015,31(2):364-368.
[13]Vairaktaris E,Yapijakis C,Serefoglou Z,et al.The interleukin-8(-251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma[J].Eur J Surg Oncol,2007,33(4):504-507.
[14]Cui Y,Zhu JJ,Ma CB,et al.Interleukin 10 gene-1082A/G polymorphism is associated with osteosarcoma risk and poor outcomes in the Chinese population[J].Tumour Biol,2016,37(4):4517-4522.
[15]AlSuhaibani ES,Kizilbash NA,Malik S,et al.Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer:A case-control study[J].Genet Mol Res,2016,15(1):56.
[16]Horvat V,Mandic S,Marczi S,et al.Association of IL-1 beta and IL-10 polymorphisms with prostate cancer risk and grade of disease in Eastern Croatian population[J].Coll Antropol,2015,39(2):393-400.
[17]Mukaida N,Shiroo M,Matsushima K.Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8[J].J Immunol,1989,143:1366-1371.
[18]Beck A,Pazolt D,Grabenbauer GG,et al.Expression of cytokine and chemokine genes in Epstein-Barr virus associated nasopharyngeal carcinoma:Comparison with Hodgkin's disease[J].J Pathol,2001,194:145.
[19]Chen Y,Yang Y,Liu S,et al.Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population:A case-control study[J].Tumour Biol,2016,37(5):6191-6196.
[20]Kumar S,Kumari N,Mittal RD,et al.Association between pro-(IL-8) and anti-inflammatory(IL-10) cytokine variants and their serum levels and Hp-related gastric carcinogenesis in northern India[J].Meta Gene,2015,6:9-16.
[21]Singh PK,Chandra G,Bogra J,et al.Association of genetic polymorphism in the interleukin-8 gene with risk of oral cancer and its correlation with pain[J].Biochem Genet,2016,54(1):95-106.
[22]Dinarello CA.Biologic basis for interleukin-1 in disease[J].Blood,1996,87:2095-2147.
[23]Heresbach D,Alizadeh M,Dabadie A,et al.Significance of interleukin-1 beta and interleukin-1 receptor antagonist genetic polymorphism in inflammatory bowel diseases[J].Am J Gastroenterol,1997,92:1164-1169.
[24]He Y,Liang X,Meng C,et al.Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk[J].Int Orthop,2014,38(8):1671-1676.
[25]Wang JL,Nong LG,Wei YS,et al.Association of interleukin-12 polymorphisms and serum IL-12p40 levels with osteosarcoma risk[J].DNA Cell Biol,2013,32(10):605-610.
[26]Tang YJ,Wang JL,Nong LG,et al.Associations of IL-27 polymorphisms and serum IL-27p28 levels with osteosarcoma risk[J].Medicine(Baltimore),2014,93(10):e56.
[27]Esteller M,Sanchez-Cespedes M,Rosell R,et al.Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients[J].Cancer Res,1999,59(1):67-70.
[28]Pellatt AJ,Wolff RK,Lundgreen A,et al.Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study[J].Int J Mol Epidemiol Genet,2012,3:184-194.
[29]Dong YZ,Huang YX,Lu T.Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population[J].Genet Mol Res,2015,14(1):1899-1902.
[30]Zhi LQ,Ma W,Zhang H,et al.Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population[J].Tumour Biol,2014,35(4):3255-3259.
[31]Jin G,Wang M,Chen W,et al.Single nucleotide polymorphisms of nucleotide excision repair and homologous recombination repair pathways and their role in the risk of osteosarcoma[J].Pak J Med Sci,2015,31(2):269-273.
[32]Ma X,Zhang Y,Sun TS,et al.Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma[J].Genet Mol Res,2016,15(1):gmr15017302.
[33]Wang Z.Association of polymorphism of ARHGAP35 gene with genetic susceptibility and clinical prognosis of osteosarcoma[D].Nanning:Guangxi Medical University,2014.[王哲.ARHGAP35基因多态性与骨肉瘤的遗传易感性及临床预后的相关性研究[D].南宁:广西医科大学,2014.]
[34]Lu XF, Yang WL, Wan ZH, et al.Glutathione S-transferase polymorphisms and bone tumor risk in China[J].Asian Pac J Cancer Prev,2011,12(12):3357-3360.
[35]Li XX,Xiao Y.Meta analysis of glutathione S-transferase M1,T1 gene polymorphism and osteosarcoma susceptibility [J].Shandong Medical J,2013,53(36):11-13.[李夏西,肖颖.谷胱甘肽S-转移酶M1、T1基因多态性与骨肉瘤易感性的Meta分析[J].山东医药,2013,53(36):11-13.]
[36]Courtney KD,Corcoran RB,Engelman JA.The PI3K pathway as drug target in human cancer[J].J Clin Oncol,2010,28:1075-1083.
[37]He ML,Wu Y,Zhao JM,et al.PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population[J].Asian Pac J Cancer Prev,2013,14(9):5117-5122.
[38]Teft WA,Kirchhof MG,Madrenas J.A molecular perspective of CTLA-4 function[J].Annu Rev Immunol,2006,24:65-97.
[39]Contardi E,Palmisano GL,Tazzari PL,et al.CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction[J].Int J Cancer,2005,117(4):538-550.
[40]He J,Wang J,Wang D,et al.Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population[J].Endocrine,2014,45(2):325-330.
[41]Tsuji T.Physiological and pathological roles of alpha3 beta1 integrin[J].J Membr Biol,2004,200(3):115-132.
[42]Yang W,He M,Zhao J,et al.Association of ITGA3 gene polymorphisms with susceptibility and clinicopathological characteristics of osteosarcoma[J].Med Oncol,2014,31(2):826.
[43]Zhang Shiquan,Xiao Deming,Zhu Yuhua,et al.Expression and clinical significance of p53 gene in osteosarcoma[J].Modern Oncology,2011,19(01):145-146.[张世权,肖德明,朱玉华,等.p53基因在骨肉瘤中的表达及其临床意义[J].现代肿瘤医学,2011,19(01):145-146.]
[44]Liu Y,Teng Z,Wang Y,et al.Prognostic significance of survivin expression in osteosarcoma patients:A Meta-analysis[J].Med Sci Monit,2015,21:28877-28885.
[45]Hu D,Huang JW,Hu SP,et al.Expression and correlation of p53,p63 and p73 protein in osteosarcoma[J].Chin J Bone Tumor and Bone Disease,2004,03(01):47-50.[胡丹,黄健文,胡世平,等.p53、p63、p73蛋白在骨肉瘤中的表达及相关性研究[J].中国骨肿瘤骨病,2004,03(01):47-50.]

Memo

Memo:
国家自然科学基金资助项目(编号:81260315);广西自然科学基金项目(编号:2012GXNSFAA053169);广西壮族自治区卫生厅重点课题项目(编号:重2010059)
Last Update: 2016-12-01