|Table of Contents|

Research progress of the role of lncRNA as biomarkers and MEG3 in tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
308-311
Research Field:
Publishing date:

Info

Title:
Research progress of the role of lncRNA as biomarkers and MEG3 in tumors
Author(s):
Wang Yuwen1; Cheng Binglin1; Zhang Shujun2
1.Department of Integrated Traditional Chinese and Western Medicinal Oncology,the First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001,China；2.Department of Pathology,the Fourth Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
lncRNA; MEG3; biomarkers; tumor; suppression
PACS:
R730.4
DOI:
10.3969/j.issn.1672-4992.2017.02.040
Abstract:
Long noncoding RNAs（lncRNAs) is a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lacked protein coding potential.On the one hand,some lncRNAs can have highly specific expression in particular types of cancer making them a promising tool for diagnosis.On the other hand,the expression of other lncRNAs can correlate and different pathophysiological features of tumor growth and patient survival,thus making them convenient biomarkers for prognosis.Maternally expressed gene 3（MEG3)，one of the lncRNAs as imprinted genes,including 12 isoforms,encodes the long non-coding RNA（lncRNA) which is associated with tumor.MEG3 plays a role in cancinogenesis by regulating p53 and promoting angiogenesis,suggesting that MEG3 and its isoforms can be used as a novel lncRNA tumor suppressor.In recent years,the research of lncRNA and tumorigenesis has become the focus.In this paper,we summarize the research progress of the role of lncRNA as biomarkers and MEG3 and its isoforms on tumor diseases.

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Memo

Memo:
黑龙江省自然科学基金（编号：H2015094）
Last Update: 2016-12-01