|Table of Contents|

Expression and significance of p63 and Ki67 in cervical intraepithelial neoplasia（CIN） and cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
273-275
Research Field:
Publishing date:

Info

Title:
Expression and significance of p63 and Ki67 in cervical intraepithelial neoplasia（CIN） and cervical cancer
Author(s):
Chen Wei1; Zhao Yong2
1.Department of Pathology,Chongqing Sixth People's Hospital,Chongqing 400060,China;2.Department of Pathology,Chongqing University of Medical Sciences,Chongqing 400016,China.
Keywords:
p63; Ki67; cervical cancer; immunohistochemistry
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2017.02.030
Abstract:
Objective:To study the expression and clinical significance of p63 and Ki67 in cervical intraepithelial neoplasia（CIN） and cervical cancer.Methods:Immunohistochemistry SP method was used to detect the expression of p63 and Ki67 in 115 cases of CIN and cervical cancer and 30 cases of normal cervical tissues.Results:The positive expression rate of p63 and Ki67 in normal cervical epithelium,CIN I,CIN Ⅱ,CIN Ⅲ and cervical invasive cancer were 6.7%,40.0%,44.0%,76.0%,97.8% and 6.7%,35.0%,44.0%,80.0%,100.0% respectively.The positive expression rate of p63 and Ki67 was significantly different between CIN and infiltrating carcinoma（P＜0.05).The expressions of p63 and Ki67 had a positive correlation between CIN and cervical cancer（P＜0.05）.The positive expression of p63 and Ki67 were closely correlated with clinical stage and pathological grade of cervical cancer（P＜0.05）.Conclusion:p63 and Ki67 might be used as markers for aggressive biological behaviour in cervical cancer,and might be useful to distinguish CIN and cervical cancer.

References:

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Last Update: 2016-12-01