|Table of Contents|

Pathological dignosis and clinical analysis of primary pulmonary synovial sarcoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
897-899
Research Field:
Publishing date:

Info

Title:
Pathological dignosis and clinical analysis of primary pulmonary synovial sarcoma
Author(s):
Zhang Xiuwei1; Qi Fengjie2; Yu Juanhan3
1.Department of Pathology，the Fourth Hospital Affiliated to China Medical Uiniversity，Liaoning Shenyang 110032，China;2.Department of Pathology,Frist Affilited Hospital of Liaoning Medical University,Liaoning Jinzhou 121001,China;3.Department of Pathology，School of Basic Medical Sciences,China Medical University,Liaoning Shenyang 110001,China.
Keywords:
primary pulmonary synovial sarcoma (PPSS）; immunohistochemistry; pulmonary lobectomy
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2016.06.014
Abstract:
Objective:To explore the dignosis and treatment as well as follow-up of 6 cases of primary pulmonary synovial sarcoma (PPSS）.Methods:The pathological and immunohistochemistry characters,diagnosis and treatment of PPSS were analyzed.Results:Histologic features of PPSS has the differential character of mesenchymal and epithelial tissue.Among 6 cases,5 were single phase type of synovial sarcoma,and 1 was bipolar synovial sarcoma.Immunohistochemical results showed that the tumor cells CK,CD99,Bcl-2,Vimentin,and Ki-67 positive expression,meanwhile TTF-1,CD34 negative expression.PPSS' clinical symptoms were not specific.4 cases were performed single pulmonary lobectomy.Conclusion:PPSS is a rare pulmonary malignant tumor,it has high malignant degree.Because of its clinical symptoms are not specific,diagnosis relies on pathological and immunohistochemical results,molecular genetic testing to identify meaningful.Early diagnosis and active surgical treatment may be effective to improve the prognosis.

References:

［1］Dennison S,Weppler E,Giacoppe G.Primary pulmonary synovial sarcoma:a case report and review of current diagnostic and therapeutic standards［J］.Oncologist,2004,9(3):339-342.
［2］William D Travis,Meng YH,Zhang JZ,et al.Pathology ＆genetics tumours of the lung,pleura,thymus and heart［M］.Beijing:People's Health Publishing House,2006：125.［William D Travis,孟宇宏,张建中,等.肺、 胸膜、 胸腺及心脏肿瘤病理学和遗传学［M］.北京：人民卫生出版社，2006：125.］
［3］Hartel PH,Fanburg-Smith JC,Frazier AA,et al.Primary pulmonary and mediastinal synovial sarcoma:A clinicopath- ologic study of 60 cases and comparison with five prior series［J］.Mod Pathol,2007,20:760-769.
［4］Alcaraz-Garca P,Daz-Palacios S,Castillo-Canto C.Primary pulmonary biphasic synovial sarcoma:a case report and literature review［J］.Cir Cir,2012,80(1):67-71.
［5］Miura Y,Keira Y,Ogino J,et al.Detection of specific genetic abnormalities by fluorescence in situ hybridization in soft tissue tumors［J］.Pathol Int,2012,62:16-27.
［6］Kim GH,Kim MY,Koo HJ,et al.Primary pulmonary synovial sarcoma in a tertiary referral center:Clinical characteristics,CT,and 18F-FDG PET findings,with pathologic correlations［J］.Med (Baltimore),2015,94(34):e1392.
［7］Petrosyan A,Bergeron P.Extensive surgical treatment of primary pulmonary synovial sarcoma after recurrent pneumothorax［J］.Ann Thorac Surg,2015,100(5):1893-1895.
［8］Trassard M,Le Doussal V,Hacène K,et al.Prognostic factors in localized primary synovial sarcoma:a multicenter study of 128 adult patients［J］.J Clin Oncol,2001,19:525-534.
［9］Satoh H,Takayashiki N,Shiozawa T,et al.Recurrent pulmonary synovial sarcoma effectively treated with amrubicin:A case report［J］.Exp Ther Med,2015,9(5):1947-1949.
［10］Maekura T,Shimizu S,Kawaguchi T,et al.Intravascular synovial sarcoma of the pulmonary artery with massive pleural effusion:report of a case with a favorable response to Ifosfamide chemotherapy and palliative radiation therapy［J］.Intern Med,2015,54(9):1095-1098.

Memo

Memo:
国家自然科学基金资助项目(编号：81301837)
Last Update: 2016-01-29