|Table of Contents|

Angiogenesis inhibition mechanism of luteolin in human cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2015 13
Page:
1810-1812
Research Field:
Publishing date:

Info

Title:
Angiogenesis inhibition mechanism of luteolin in human cancer
Author(s):
Li Wenfang1Ou Qin2Wang Geng1Zhao Zongbin1
1.Taihe Hospital Affiliated to Hubei Medical University,Hubei Shiyan 442000,China;2.Biology Department of Hubei Medical University,Hubei Shiyan 442000,China.
Keywords:
luteolinIL-8endothelial cells
PACS:
R73-3
DOI:
10.3969/j.issn.1672-4992.2015.13.08
Abstract:
Objective:To study the blood vessels inhibition mechanism with luteolin.Methods:Different concentrations of luteolin processing human microvascular endothelial cells,cell growth,and MDA-MB 231 culture medium mediated chemotaxis were observed,and IL-8 signal in endothelial cell activation was observed.Results:Luteolin inhibited microvascular endothelial cell proliferation,and breast cancer cells MDA-MB 231 culture medium mediated of endothelial cell chemotaxis,and significantly inhibited IL-8 on endothelial cell activation.Conclusion:Luteolin can inhibit microvascular endothelial cell proliferation and MDA-MB 231 culture medium mediated chemotaxis.Luteolin can inhibit the IL-8 signal activation of human microvascular endothelial cells,indicates luteolin anti-angiogenesis effect in the prevention of cancer recurrence and metastasis.

References:

[1]L Holmgren,MSO Reilly,J Folkman.Dormancy of micrometastas es:balanced proliferation and apoptosis in the presence of angiogenesis suppression[J].Nature Med,1995,1(2):149-153.
[2]Jensen R,Lee J.Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia,vascularity,and prolif eration[J].Neurosurgery,2012,71(1):146-156.
[3]Lippitz BE.Cytokine patterns in patients with cancer:a systematic review[J].Lancet Oncol,2013,14(6):e218-228.
[4]Ariane Freund,Valerie Jolivel,Sebastien Durand,et al.Mechanisms underlying differential expression of interleukin-8 in breast cancer cells[J].Oncogene,2004,23:6105-6114.
[5]Lei Wang,Jeffrey Ho,Carlotta Glackin,et al.Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis[J].Trans Oncol,2012,5(5):344-355.
[6]Kim SW,Hayashi M,Lo JF,et al.Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8[J].Cancer Res,2005,65(19):8784-8791.
[7]Christophe Ginestier,Suling Liu,Mark E Diebel,et al.CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts[J].J Clin Res,2010,120(2):486-489.
[8]Pratheeshkumar P,Son YO,Budhraja A,et al.Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis[J].Plos One,2012,7(12):e52279.

Memo

Memo:
-
Last Update: 2015-05-29