|Table of Contents|

Heat shock protein HSP27 inhibits the invasion and metastasis of esophageal carcinoma cell lines

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2014 01
Page:
11-0015
Research Field:
Publishing date:

Info

Title:
Heat shock protein HSP27 inhibits the invasion and metastasis of esophageal carcinoma cell lines
Author(s):
Xue Lin1; Yang Lei2; Liu Bing1; Li Hong1; Kang Jianqin1; Wang Biaoluo1; Liang Shuhui1; Ding Jie1
1.State Key Laboratory of Caner Biology,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Shaanxi Xi'an 710032,China;2.Baoji City Second People's Hospital,Shaanxi Baoji 721000,China.
Keywords:
esophageal squamous cell carcinoma; HSP27; invasion; metastasis
PACS:
R73-36+2；R735.1
DOI:
10.3969/j.issn.1672-4992.2014.01.04
Abstract:
Objective:To explore the relationship between the expression of heat shock protein 27 (HSP27) and the invasive and metastatic potential of human esophageal squamous cell carcinoma (ESCC) cell lines.Methods:Scratch assays were performed to identify the differences and changes of invasive and metastatic ability in ESCC cell lines.Western blot were used to examine the differences of HSP27 expression in ESCC cell lines.Lentivirus infection technique was employed to up-regulate the expression of HSP27 in highly metastatic cells.Results:The invasive and metastatic potentials of EC9706-H and EC109-H cells were higher than the matched EC9706-L and EC109-L cells.The expression levels of HSP27 in EC9706-H and EC109-H cells were lower than the matched EC9706-L and EC109-L cells.The invasive and metastatic potentials of EC9706-H and EC109-H cells were significantly decreased after overexpression of HSP27.Conclusion：The expression level of HSP27 may be inversely correlated to the invasive and metastatic behavior of ESCC cell lines and up-regulating the expression of HSP27 can inhibit the invasion and metastasis ability of ESCC.

References:

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Memo

Memo:
国家自然科学基金资助项目（编号：30900674，81272516，30973428，81090273，81090274），陕西省科技计划项目（编号：2011K12-03-06）
Last Update: 2013-12-03