|Table of Contents|

Research progress of ovarian small cell neuroendocrine carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 04
Page:
690-694
Research Field:
Publishing date:

Info

Title:
Research progress of ovarian small cell neuroendocrine carcinoma
Author(s):
WEI Jia1GUO Xi1LIU Simin1WANG Jiali1ZHENG Duo2LI Hongli2YANG Yongxiu2
1.The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China;2.Department of Obstetrics and Gynecology,the First Hospital of Lanzhou University,Gansu Provincial Clinical Research Center for Gynecological Oncology,Gansu Lanzhou 730000,China.
Keywords:
malignant ovarian tumorsovarian small cell neuroendocrine carcinomadiagnosistreatment
PACS:
R737.31
DOI:
10.3969/j.issn.1672-4992.2025.04.022
Abstract:
Ovarian small cell neuroendocrine carcinoma(SCNEC) is a rare malignant tumor of the ovary that progresses rapidly and has a poor prognosis.The 5th edition of the WHO classification of female reproductive tract tumors classifies it as ovarian neuroendocrine tumors.At present,most of the research on it both domestically and internationally is based on individual case reports,and there is still a lack of sufficient understanding and clinical guidelines for ovarian small cell neuroendocrine carcinoma.The exact tissue origin and pathogenesis of SCNEC are not yet clear.This article reviews the diagnosis,differential diagnosis,treatment methods,and prognosis of SCNEC.

References:

[1] LHEUREUX S,BRAUNSTEIN M,OZA AM.Epithelial ovarian cancer:Evolution of management in the era of precision medicine [J].CA:A Cancer Journal for Clinicians,2019,69(4):280-304.
[2] ONEDA E,ZORZI F,GORIO A,et al.Differential diagnosis of small cell carcinoma of the ovary or ovarian metastases of small cell carcinoma of the lung:A case report and review of the literature [J].Case Reports in Oncology,2020,13(2):822-828.
[3] SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
[4] CABASAG CJ,FAGAN PJ,FERLAY J,et al.Ovarian cancer today and tomorrow:A global assessment by world region and human development index using GLOBOCAN 2020 [J].International Journal of Cancer,2022,151(9):1535-1541.
[5] DAVIES M,DAVEY MG,MILLER N.The potential of microRNAs as clinical biomarkers to aid ovarian cancer diagnosis and treatment [J].Genes,2022,13(11):2054.
[6] ZHANG M,CHENG S,JIN Y,et al.Roles of CA125 in diagnosis,prediction,and oncogenesis of ovarian cancer [J].Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,2021,1875(2):188503.
[7] MCCLUGGAGE WG,SINGH N,GILKS CB.Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020) [J].Histopathology,2022,80(5):762-778.
[8] WINER I,KIM C,GEHRIG P.Neuroendocrine tumors of the gynecologic tract update [J].Gynecol Oncol,2021,162(1):210-219.
[9] GEORGESCU TA,BOHILTEA RE,MUNTEANU O,et al.Emerging therapeutic concepts and latest diagnostic advancements regarding neuroendocrine tumors of the gynecologic tract [J].Medicina,2021,57(12):1338.
[10] EICHHORN JH,YOUNG RH,SCULLY RE.Primary ovarian small cell carcinoma of pulmonary type [J].The American Journal of Surgical Pathology,1992,16(10):926-927.
[11] MIGLIETTA S,GIROLIMETTI G,MARCHIO L,et al.MicroRNA and metabolic profiling of a primary ovarian neuroendocrine carcinoma pulmonary type reveals a high degree of similarity with small cell lung cancer [J].Non-coding RNA,2022,8(5):64-77.
[12] ZHAO FH,WANG JS,LIU HL,et al.Primary ovarian small cell carcinoma of pulmonary type:Analysis of 6 cases and review of 31 cases in the literatures [J].Chinese Medical Sciences Journal,2023,38(2):130-137.
[13] PARK HK.Neuroendocrine carcinomas of the uterine cervix,endometrium,and ovary show higher tendencies for bone,brain,and liver organotrophic metastases [J].Current Oncology,2022,29(10):7461-7469.
[14] BRENNAN SM,GREGORY DL,STILLIE A,et al.Should extrapulmonary small cell cancer be managed like small cell lung cancer[J].Cancer,2010,116(4):888-895.
[15] JOSELUIS HR.Ovarian neuroendocrine carcinoma-case report [J].Obstetrics & Gynecology International Journal,2016,4(3):80-82.
[16] HAYASE T,MATSUBARA D,MAEDA K,et al.Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase [J].Pediatrics International,2018,60(10):982-983.
[17] TERADA S,SUZUKI T,HASEGAWA A,et al.The cytoreductive effect of radiotherapy for small cell ovarian carcinoma of the pulmonary type:A case report and review of the literature [J].Case Reports in Obstetrics and Gynecology,2018,2018(1):1-6.
[18] LENCHNER JR,SANTOS C.Biochemistry,5 hydroxyindoleacetic acid [M].Treasure Island(FL),StatPearls Publishing,2024:10-15.
[19] XING XY,ZHANG W,LIU LY,et al.Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma [J].World Journal of Clinical Cases,2024,12(6):1111-1119.
[20] PANG L,GUO Z.Primary neuroendocrine tumors of the ovary:Management and outcomes [J].Cancer Medicine,2021,10(23):8558-8569.
[21] LI Y,WU Y,ZHANG Y,et al.Case report:Strategies for improving outcomes in patients with primary ovarian small-cell neuroendocrine carcinoma [J].Frontiers in Oncology,2022,12(16):954289.
[22] GUPTA P,KAPATIA G,GUPTA N,et al.Small cell carcinoma of the ovary:Clinicopathologic and immunohistochemical analysis of 7 new cases of a rare malignancy [J].Int J Surg Pathol,2021,29(3):236-245.
[23] ZHU Y,MENG F,FANG H,et al.Clinicopathologic characteristics and survival outcomes in neuroendocrine carcinoma of the ovary [J].Int J Gynecol Cancer,2020,30(2):207-212.
[24] CHAD R RUND,EDGAR G FISCHER.Perinuclear dot-like cytokeratin 20 staining in small cell neuroendocrine carcinoma of the ovary pulmonaary type[J].Appl Immunohistochem Mol Morphol,2006,14(2):244-248.
[25] NASIOUDIS D,CHAPMAN-DAVIS E,FREY MK,et al.Small cell carcinoma of the ovary:A rare tumor with a poor prognosis [J].Int J Gynecol Cancer,2018,28(5):932-938.
[26] WANG J,NING Y,DU Y,et al.Lymphadenectomy benefits small cell carcinoma of ovary:A population-based analysis [J].Current Oncology,2022,29(10):7802-7815.
[27] YAGHMOUR G,PROUET P,WIEDOWER E,et al.Genomic alterations in neuroendocrine cancers of the ovary [J].Journal of Ovarian Research,2016,9(1):52-57.
[28] TISCHKOWITZ M,HUANG S,BANERJEE S,et al.Small-cell carcinoma of the ovary,hypercalcemic type-genetics,new treatment targets,and current management guidelines [J].Clinical Cancer Research,2020,26(15):3908-3917.
[29] MOSELE F,REMON J,MATEO J,et al.Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers:a report from the ESMO Precision Medicine Working Group [J].Annals of Oncology,2020,31(11):1491-1505.
[30] SU X,ZHOU X,XIAO C,et al.Complete response to immunotherapy combined with chemotherapy in a patient with gynecological mixed cancer mainly composed of small cell neuroendocrine carcinoma with high tumor mutational burden:A case report [J].Frontiers in Oncology,2022,12(16):750970.
[31] PANG L,WANG S.Prevalence,associated factors,and survival outcomes of small-cell neuroendocrine carcinoma of the gynecologic tract:A large population-based analysis [J].Frontiers in Medicine,2022,9(16):1-10.
[32] HU D,MA D,ZHANG ZJ,et al.Prognosis comparison between small cell carcinoma of ovary and high-grade serous ovarian cancer:A retrospective observational cohort study [J].Frontiers in Endocrinology,2023,18(14):1103429.

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甘肃省青年科技基金(编号:23JRRA1612)
Last Update: 1900-01-01