［1］ CAI HT,LYU MM,WANG TT.PANoptosis in cancer,the triangle of cell death［J］.Cancer Medicine,2023,12(24):22206-22223.
［2］ MALIREDDI RKS,KESAVARDHANA S,KANNEGANTI TD.ZBP1 and TAK1:master regulators of NLRP3 inflammasome/pyroptosis,apoptosis,and necroptosis (PAN-optosis)［J］.Frontiers in Cellular and Infection Microbiology,2019,9:406.
［3］ CAI YH,XIAO H,ZHOU QX,et al.Comprehensive analyses of PANoptosome with potential implications in cancer prognosis and immunotherapy［J/OL］.Biochem Genet,2024(2024-03-04)［2024-05-01］.https://link.springer.com/article/10.1007/s10528-024-10687-8.DOI:10.1007/s10528-024-10687-8.
［4］ QI ZH,ZHU LL,WANG KK,et al.PANoptosis:Emerging mechanisms and disease implications［J］.Life Sciences,2023,333:122158.
［5］ OCANSEY DKW,QIAN F,CAI PP,et al.Current evidence and therapeutic implication of PANoptosis in cancer［J］.Theranostics,2024,14(2):640-661.
［6］ KARKI R,KANNEGANTI TD.ADAR1 and ZBP1 in innate immunity,cell death,and disease［J］.Trends in Immunology,2023,44(3):201-216.
［7］ CHRISTGEN S,TWEEDELL RE,KANNEGANTI TD.Programming inflammatory cell death for therapy［J］.Pharmacology & Therapeutics,2022,232:108010.
［8］ CHEN W,GULLETT JM,TWEEDELL RE,et al.Innate immune inflammatory cell death:PANoptosis and PANoptosomes in host defense and disease［J］.European Journal of Immunology,2023,53(11):2250235.
［9］ PLACE DE,LEE SJ,KANNEGANTI TD.PANoptosis in microbial infection［J］.Current Opinion in Microbiology,2021,59:42-49.
［10］ ZHENG M,KANNEGANTI TD.The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis,apoptosis,and necroptosis (PANoptosis)［J］.Immunological Reviews,2020,297(1):26-38.
［11］ CHRISTGEN S,ZHENG M,KESAVARDHANA S,et al.Identification of the PANoptosome:a molecular platform triggering pyroptosis,apoptosis,and necroptosis (PANoptosis)［J］.Frontiers in Cellular and Infection Microbiology,2020,10:237.
［12］ WANG Y,PANDIAN N,HAN JH,et al.Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method［J］.Cellular and Molecular Life Sciences,2022,79(10):531.
［13］ ZHENG M,KANNEGANTI TD.Newly identified function of caspase-6 in ZBP1-mediated innate immune responses,NLRP3 inflammasome activation,PANoptosis,and host defense［J］.Journal of Cellular Immunology,2020,2(6):341.
［14］ KARKI R,SUNDARAM B,SHARMA BR,et al.ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis［J］.Cell Reports,2021,37(3):109858.
［15］ JIAO H,WACHSMUTH L,KUMARI S,et al.Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation［J］.Nature,2020,580(7803):391-395.
［16］ SHUBINA M,TUMMERS B,BOYD DF,et al.Necroptosis restricts influenza A virus as a stand-alone cell death mechanism［J］.Journal of Experimental Medicine,2020,217(11):e20191259.
［17］ ZHENG M,KARKI R,VOGEL P,et al.Caspase-6 is a key regulator of innate immunity,inflammasome activation,and host defense［J］.Cell,2020,181(3):674-687.e13.
［18］ SHARMA BR,KARKI R,RAJESH Y,et al.Immune regulator IRF1 contributes to ZBP1-,AIM2-,RIPK1-,and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)［J］.Journal of Biological Chemistry,2023,299(9):105141.
［19］ MALIREDDI RK,KESAVARDHANA S,KARKI R,et al.RIPK1 distinctly regulates yersinia-induced inflammatory cell death,PANoptosis［J］.Immunohorizons,2020,4(12):789-796.
［20］ KURIAKOSE T,MAN SM,SUBBARAO MALIREDDI RK,et al.ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways［J］.Science Immunology,2016,1(2):aag2045.
［21］ HENKEL FDR,O’ NEILL LAJ.NLRP12 drives PANoptosis in response to heme［J］.Trends Immunol,2023,44(8):574-576.
［22］ SUNDARAM B,PANDIAN N,MALL R,et al.NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs［J］.Cell,2023,186(13):2783-2801.e20.
［23］ DU LP,WANG XY,CHEN SY,et al.The AIM2 inflammasome:A novel biomarker and target in cardiovascular disease［J］.Pharmacological Research,2022,186:106533.
［24］ LEE SJ,KARKI R,WANG YQ,et al.AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence［J］.Nature,2021,597(7876):415-419.
［25］ SHARMA BR,KARKI R,KANNEGANTI TD.Role of AIM2 inflammasome in inflammatory diseases,cancer and infection［J］.European Journal of Immunology,2019,49(11):1998-2011.
［26］ KARKI R,SHARMA BR,TULADHAR S,et al.Synergism of TNF-α and IFN-γ triggers inflammatory cell death,tissue damage,and mortality in SARS-CoV-2 infection and cytokine shock syndromes［J］.Cell,2021,184(1):149-168.e17.
［27］ XIONG Y.The emerging role of PANoptosis in cancer treatment［J］.Biomedicine Pharmacotherapy,2023,168:115696.
［28］ YI X,LI J,ZHENG XN,et al.Construction of PANoptosis signature:Novel target discovery for prostate cancer immunotherapy［J］.Molecular Therapy-Nucleic Acids,2023,33:376-390.
［29］ XIONG XF,SONG QB,JING MJ,et al.Identification of PANoptosis-based prognostic signature for predicting efficacy of immunotherapy and chemotherapy in hepatocellular carcinoma［J］.Genetics Research,2023,2023(1):6879022.
［30］ ZHU JY,TANG BF,LYU XL,et al.Identifying apoptosis-related transcriptomic aberrations and revealing clinical relevance as diagnostic and prognostic biomarker in hepatocellular carcinoma［J］.Frontiers in Oncology,2021,10:519180.
［31］ SONG F,WANG CG,MAO JZ,et al.PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma［J］.Frontiers in Immunology,2023,14:1197152.
［32］ ZHUANG L,SUN Q,HUANG S,et al.A comprehensive analysis of PANoptosome to prognosis and immunotherapy response in pan-cancer［J］.Scientific Reports,2023,13(1):3877.
［33］ HE P,MA Y,WU Y,et al.Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq［J］.Frontiers in Endocrinology,2023,14:1164930.
［34］ WANG W,ZHOU Q,LAN L,et al.PANoptosis-related prognostic signature predicts overall survival of cutaneous melanoma and provides insights into immune infiltration landscape［J］.Scientific Reports,2023,13(1):8449.
［35］ WANG Y,ZHOU J,ZHANG N,et al.A novel defined PANoptosis-related miRNA signature for predicting the prognosis and immune characteristics in clear cell renal cell carcinoma:A miRNA signature for the prognosis of ccRCC［J］.International Journal of Molecular Sciences,2023,24(11):9392.
［36］ MALL R,BYNIGERI RR,KARKI R,et al.Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology［J］.NAR Cancer,2022,4(4):zcac033.
［37］ WEI SY,CHEN ZG,LING XY,et al.Comprehensive analysis illustrating the role of PANoptosis-related genes in lung cancer based on bioinformatic algorithms and experiments［J］.Frontiers in Pharmacology,2023,14:1115221.
［38］ KARKI R,SHARMA BR,LEE E,et al.Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer［J］.JCI Insight,2020,5(12):e136720.
［39］ LIN JF,HU PS,WANG YY,et al.Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis［J］.Signal Transduction and Targeted Therapy,2022,7(1):54.
［40］ LIU LX,HENG JH,DENG DX,et al.Sulconazole induces PANoptosis by triggering oxidative stress and inhibiting glycolysis to increase radiosensitivity in esophageal cancer［J］.Molecular & Cellular Proteomics,2023,22(6):100551.
［41］ PAN H,PAN J,LI P,et al.Characterization of PANoptosis patterns predicts survival and immunotherapy response in gastric cancer［J］.Clinical Immunology,2022,238:109019.
［42］ SONG JJ,XU ZQ,FAN QC,et al.The PANoptosis-related signature indicates the prognosis and tumor immune infiltration features of gliomas［J］.Frontiers in Molecular Neuroscience,2023,16:1198713.