|Table of Contents|

New progress in the role of synaptotagmin family members in cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 24
Page:
4687-4692
Research Field:
Publishing date:

Info

Title:
New progress in the role of synaptotagmin family members in cancer
Author(s):
ZHAO Yanqing1; YANG Jie2; LIAO Chenggong3; KONG Lingmin2
1.Air Force Medical University Student Team five and Team nineteen,Shaanxi Xi’an 710032,China;2.Department of Cell Biology,National Translational Science Center for Molecular Medicine,Air Force Medical University,Shaanxi Xi’an 710032,China;3.Department of Oncology,Tangdu Hospital,Cancer Institute,Air Force Medical University,Shaanxi Xi’an 710038,China.
Keywords:
synaptotagmin; cancer; oncogene; biomarker; prognosis
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2024.24.016
Abstract:
More tumor-related genes were discovered with the development of bioinformatics and public databases.Synaptotagmins (SYTs) are a kind of membrane proteins abundant in synaptic vesicles and chromaffin cell granules,and their evolution is highly conserved.It consists of a short N-terminal sequence,a variable connectivity domain,a transmembrane domain,and two C2 domains.Seventeen subtypes of SYTs have been found in mammalian cells,which are widely distributed and have complex functions.Studies have shown that SYTs regulate calcium dependent membrane fusion events,and some family members are also associated with hormone secretion or neurotransmitter release.Many pieces of evidence support SYTs as a Ca2+ receptor of exocytosis.In recent years,it has been shown that SYTs are highly correlated with the occurrence and development of various tumors.Downregulating the expression of SYTs inhibits the proliferation,migration,and invasion,but promotes cell apoptosis of tumor cells.The growth of peritoneal nodules in mice injected with siSYT was inhibited and the survival time of the mice was prolonged.Therefore,SYTs can serve as a carcinogenic gene and potentially become a prognostic biomarker for various cancers.This article provides an overview of recent research on the role of SYT family members in cancer and highlights the progress that has been made.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.82202967);国家自然科学基金青年项目（编号:82202967）;National Natural Science Foundation of China(No.82372971);国家自然科学基金面上项目（编号:82372971）;空军军医大学军事医学提升计划（编号：2021JSTS15）;陕西省自然科学基础研究计划（编号：2023-JC-ZD-45）;唐都医院社会人才基金资助计划（编号：2021SHRC001）;肿瘤生物学国家重点实验室自主课题（编号：CBSKL2022ZZ36）
Last Update: 1900-01-01