|Table of Contents|

The molecular mechanism of DDB2 in the occurrence and development of cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 24
Page:
4680-4686
Research Field:
Publishing date:

Info

Title:
The molecular mechanism of DDB2 in the occurrence and development of cancer
Author(s):
ZHOU Wenqian12ZHAO Wenjian1GUO Jiuru1WANG Liang1
1.Tangdu Hospital,Air Force Medical University,Shaanxi Xi'an 710038,China;2.Four Brigades of the School of Basic Medicine,Air Force Medical University,Shaanxi Xi'an 710032,China.
Keywords:
DDB2UV-DDBNERcancerprogress
PACS:
R730.231
DOI:
10.3969/j.issn.1672-4992.2024.24.015
Abstract:
Damage-specific DNA binding protein 2 (DDB2) is a component of the damage-specific DNA binding heterodimer complex.It cooperates with other proteins to repair UV-induced DNA damage,participates in the occurrence and development of cancer by affecting nucleotide excision repair (NER),apoptosis and premature aging,and affects the sensitivity of cancer cells to radiotherapy and chemotherapy.A number of studies have found that DDB2 is involved in the carcinogenesis of colorectal cancer,gastric cancer,breast cancer and other cancers,and plays a key role in tumor inhibition.This article reviews the molecular mechanisms of different biological processes involving DDB2,in order to provide theoretical support for the study of drugs targeting DDB2.

References:

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Memo

Memo:
陕西省杰出青年科学基金项目(编号:2023-JC-JQ-68);陕西省高校青年创新团队项目(编号:2022-61)
Last Update: 1900-01-01