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The expression and clinical significance of ZSWIM4 in ovarian serous cystadenocarcinoma tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 24
Page:
4638-4643
Research Field:
Publishing date:

Info

Title:
The expression and clinical significance of ZSWIM4 in ovarian serous cystadenocarcinoma tissues
Author(s):
ZENG Kai1; 2; HU Yuexin1; 2; FAN Xiangcheng1; 2; LIU Ouxuan1; 2; LI Xinru1; 2; WEI Xiaojing1; 2; XIA Beibei1; 2; ZHANG Yuchen1; 2; LI Xiao1; 2;  LIN Bei1; 2
1.Department of Gynecology and Obstetrics,Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110004,China;2.Key Laboratory of Maternal Fetal Medicine of Liaoning Province,Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning Province,Liaoning Shenyang 110004,China.
Keywords:
ZSWIM4; ovarian serous cystadenocarcinoma; immunohistochmistry
PACS:
R737.31
DOI:
10.3969/j.issn.1672-4992.2024.24.009
Abstract:
Objective:To investigate the expression of ZSWIM4 in ovarian serous cystadenocarcinoma tissues,as well as its correlation with clinical and pathological parameters and prognosis of ovarian cancer patients.Methods:Immunohistochemistry staining was used to assess the expression of ZSWIM4 in 74 cases of ovarian serous cystadenocarcinoma,including 17 cases of ovarian borderline tumor tissues,21 cases of epithelial benign tumor tissues,and 17 cases of normal ovarian tissues.The correlation between ZSWIM4 expression and clinical and pathological parameters and prognosis of ovarian serous cystadenocarcinoma patients was analyzed.Results:ZSWIM4 was mainly expressed in the nucleus,with a small amount in the cytoplasmic expression.The positive and high-positive rates of ZSWIM4 in the ovarian serous cystadenocarcinoma group(87.8% and 63.5%) were significantly higher than those in the borderline tumor group(52.9% and 23.5%),the benign tumor group(23.8% and 4.8%),and the normal ovarian tissues(11.8% and 5.9%) (P<0.01).In this study,we found that ZSWIM4 showed no significant correlation with patients' age,FIGO stage,tumor differentiation,or lymph node metastasis(P>0.05).The high expression of ZSWIM4 significantly shortened patients' overall survival time(P<0.01),and the expression of ZSWIM4 was identified as an independent risk factor for patients' prognosis(P<0.01).Conclusion:ZSWIM4 is over expressed in ovarian serous cystadenocarcinoma tissues.As a prognostic factor for ovarian cancer,ZSWIM4 is expected to serve as a new biomarker for prognostic risk assessment,as well as a potential target for clinical treatment.

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Memo

Memo:
National Natural Science Foundation of China(No.82173130);国家自然科学基金（编号：82173130）；辽宁省科学技术计划（编号：2022JH2/20200047）
Last Update: 1900-01-01