［1］HANAHAN D.Hallmarks of cancer:New dimensions［J］.Cancer Discov,2022,12(1):31-46.
［2］ZHANG K,SUN L,KANG Y.Regulation of phosphoglycerate kinase 1 and its critical role in cancer［J］.Cell Commun Signal,2023,21(1):240-251.
［3］CHIARELLI LR,MORERA SM,BIANCHI P,et al.Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency［J］.PLoS One,2012,7(2):e32065.
［4］范骏.翻译后修饰与肿瘤代谢重编程［J］.中山大学学报(医学科学版),2022,43(2):161-172.
FAN J.Post-translational modification and tumor metabolic reprogram［J］.Journal of Sun Yat-sen University(Medical Science Edition),2022,43(2):161-172.
［5］MEDEIROS H,LUNT SY.The Warburg effect:Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation［J］.Mol Cell,2022,82(17):3119-3121.
［6］HE Y,LUO Y,ZHANG D,et al.PGK1-mediated cancer progression and drug resistance［J］.Am J Cancer Res,2019,9(11):2280-2302.
［7］QI F,ZHENHAI Y.Phosphoglycerate kinase 1(PGK1) in cancer:A promising target for diagnosis and therapy［J］.Life Sciences,2020,256:117863.
［8］LIU H,WANG X,SHEN P,et al.The basic functions of phosphoglycerate kinase 1 and its roles in cancer and other diseases［J］.Eur J Pharmacol,2022,920:174835.
［9］LI X,JIANG Y,MEISENHELDER J,et al.Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis［J］.Mol Cell,2016,61(5):705-719.
［10］黄靖.L-5-羟基色氨酸和磷酸甘油酸激酶1在调控肿瘤微环境中的作用及机制研究［D］.上海：中国科学院大学(中国科学院上海药物研究所),2022.
HUANG J.Role and mechanism of L-5-hydroxytryptophan and phosphoglycerate kinase 1 in regulating tumor microenvironment ［D］.Shanghai:University of Chinese Academy of Sciences(Shanghai Institute of Pharmaceutical Sciences,Chinese Academy of Sciences),2022.
［11］SUN L,ZHANG H,GAO P.Metabolic reprogramming and epigenetic modifications on the path to cancer［J］.Protein Cell,2022,13(12):877-919.
［12］MEDINA MA.Metabolic reprogramming is a hallmark of metabolism itself［J］.BioEssays:News and Reviews in Molecular,Cellular and Developmental Biology,2020,42(10):e2000058.
［13］SHVEDUNOVA M,AKHTAR A.Modulation of cellular processes by histone and non-histone protein acetylation［J］.Nat Rev Mol Cell Biol,2022,23(5):329-349.
［14］DUNCAN L,SHAY C,TENG Y.PGK1:An essential player in modulating tumor metabolism［J］.Methods Mol Biol,2022,2343:57-70.
［15］FU Y,YU J,LI F,et al.Oncometabolites drive tumorigenesis by enhancing protein acylation:From chromosomal remodelling to nonhistone modification［J］.J Exp Clin Cancer Res,2022,41(1):144-159.
［16］DIALLO I,SEVE M,CUNIN V,et al.Current trends in protein acetylation analysis［J］.Expert Rev Proteomics,2019,16(2):139-159.
［17］DING P,MA Z,LIU D,et al.Lysine acetylation/deacetylation modification of immune-related molecules in cancer immunotherapy［J］.Front Immunol,2022,13:865975.
［18］SUN L,ZHANG J,WEN K,et al.The prognostic value of lysine acetylation regulators in hepatocellular carcinoma［J］.Front Mol Biosci,2022,9:840412.
［19］NARITA T,WEINERT BT,CHOUDHARY C.Functions and mechanisms of non-histone protein acetylation［J］.Nat Rev Mol Cell Biol,2019,20(3):156-174.
［20］WANG S,JIANG B,ZHANG T,et al.Insulin and mTOR pathway regulate HDAC3-mediated deacetylation and activation of PGK1［J］.PLoS Biol,2015,13(9):e1002243.
［21］HU H,ZHU W,QIN J,et al.Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis［J］.Hepatology(Baltimore,Md.),2017,65(2):515-528.
［22］QIAN X,LI X,CAI Q,et al.Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy［J］.Mol Cell,2017,65(5):917-931.
［23］SINGH V,RAM M,KUMAR R,et al.Phosphorylation:Implications in cancer［J］.Protein J,2017,36(1):1-6.
［24］WANG R,WANG G.Protein modification and autophagy activation［J］.Adv Exp Med Biol,2019,1206:237-259.
［25］ZHANG Y,YU G,CHU H,et al.Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis［J］.Mol Cell,2018,71(2):201-215.
［26］SHAO F,YANG X,WANG W,et al.Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:A TCGA pan-cancer analysis［J］.Cancer Commun(Lond),2019,39(1):54-64.
［27］QIAN X,LI X,SHI Z,et al.PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1［J］.Mol Cell,2019,76(3):516-527.
［28］ZHANG T,WANG Y,YU H,et al.PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40［J］.Cell Death Dis,2022,13(1):68-77.
［29］ZHANG H,ZHANG Y,WANG H,et al.Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection［J］.Journal of Proteomics,2023,280:104889.
［30］LE M,LI J,ZHANG D,et al.The emerging role of lysine succinylation in ovarian aging［J］.Reprod Biol Endocrinol,2023,21(1):38-45.
［31］YANG Y,GIBSON GE.Succinylation links metabolism to protein functions［J］.Neurochem Res,2019,44(10):2346-2359.
［32］ALLEYN M,BREITZIG M,LOCKEY R,et al.The dawn of succinylation:A posttranslational modification［J］.Am J Physiol Cell Physiol,2018,314(2):C228-C232.
［33］ZHAO G,ZHEN J,LIU X,et al.Protein post-translational modification by lysine succinylation:Biochemistry,biological implications,and therapeutic opportunities［J］.Genes Dis,2023,10(4):1242-1262.
［34］张乃文.PGK1及其赖氨酸琥珀酰化修饰在肾细胞癌中的作用及其相关机制研究［D］.北京：中国医科大学,2018.
ZHANG NW.Study on the role and the related mechanism of PGK1 and its lysine succinylation modification in renal cell carcinoma［D］.Beijing:China Medical University,2018.
［35］ZHANG N,GAO R,YANG J,et al.Quantitative global proteome and lysine succinylome analyses reveal the effects of energy metabolism in renal cell carcinoma［J］.Proteomics,2018,18(19):e1800001.
［36］GAO X,BAO H,LIU L,et al.Systematic analysis of lysine acetylome and succinylome reveals the correlation between modification of H2A.X complexes and DNA damage response in breast cancer［J］.Oncol Rep,2020,43(6):1819-1830.
［37］罗跃梅.PGK1琥珀酰化影响血脑屏障通透性参与大鼠急性癫痫发作的机制研究［D］.遵义：遵义医科大学,2022.
LUO YM.Mechanism of PGK1 succinylation affecting blood-brain barrier permeability in acute epileptic seizures in rats［D］.Zunyi：Zunyi Medical University,2022.
［38］EICHLER J.Protein glycosylation［J］.Curr Biol,2019,29(7):R229-R231.
［39］HIRATA T,KIZUKA Y.N-glycosylation［J］.Adv Exp Med Biol,2021,1325:3-24.
［40］MAGALHAES A,DUARTE HO,REIS CA.The role of O-glycosylation in human disease［J］.Mol Aspects Med,2021,79:100964.
［41］NIE H,JU H,FAN J,et al.O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth［J］.Nat Commun,2020,11(1):36-45.
［42］VAIDYANATHAN K,WELLS L.Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type Ⅱ diabetes［J］.J Biol Chem,2014,289(50):34466-34471.
［43］NIE H,JU H,FAN J,et al.O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth［J］.Nat Commun,2020,11(1):36-47.
［44］FAKTOR J,PJECHOVA M,HERNYCHOVA L,et al.Protein ubiquitination research in oncology［J］.Klin Onkol,2019,32(3):56-64.
［45］BASU B,GHOSH MK.Ubiquitination and deubiquitination in the regulation of epithelial-mesenchymal transition in cancer:Shifting gears at the molecular level［J］.Biochim Biophys Acta Mol Cell Res,2022,1869(7):119261.
［46］SUN T,LIU Z,YANG Q.The role of ubiquitination and deubiquitination in cancer metabolism［J］.Mol Cancer,2020,19(1):146-158.
［47］DONG W,LI H,WU X.Rab11-FIP2 suppressed tumor growth via regulation of PGK1 ubiquitination in non-small cell lung cancer［J］.Biochem Biophys Res Commun,2019,508(1):60-65.
［48］CHU Z,HUO N,ZHU X,et al.FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect［J］.Mol Ther,2021,29(9):2737-2753.
［49］CAI Q,WANG S,JIN L,et al.Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy［J］.Mol Cancer,2019,18(1):82-96.
［50］YU T,ZHAO Y,HU Z,et al.MetaLnc9 facilitates lung cancer metastasis via a PGK1-activated AKT/mTOR pathway［J］.Cancer Res,2017,77(21):5782-5794.
［51］SCHNEIDER CC,ARCHID R,FISCHER N,et al.Metabolic alteration-Overcoming therapy resistance in gastric cancer via PGK-1 inhibition in a combined therapy with standard chemotherapeutics［J］.International Journal of Surgery,2015,22:92-98.
［52］SUN S,LIANG X,ZHANG X,et al.Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer［J］.British Journal of Cancer,2015,112(8):1332-1339.
［53］CAPLAN NA,POGSON CI,HAYES DJ,et al.Novel bisphosphonate inhibitors of phosphoglycerate kinase［J］.Bioorg Med Chem Lett,1998,8(5):515-520.
［54］KRISHNAN P,FU Q,LAM W,et al.Phosphorylation of pyrimidine deoxynucleoside analog diphosphates:Selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase［J］.J Biol Chem,2002,277(7):5453-5459.
［55］HE Y,LUO Y,ZHANG D,et al.PGK1-mediated cancer progression and drug resistance［J］.Am J Cancer Res,2019,9(11):2280-2302.
［56］WANG Y,SUN L,YU G,et al.Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products［J］.Biochem Pharmacol,2021,183(1):114343-114357.