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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 09

Page:

1699-1702

Research Field:

Publishing date:

Info

Title:

Effects of different doses of hydromorphone on hemodynamics,stress response and awaking quality in elderly patients undergoing radical resection of pulmonary carcinoma

Author(s):

XU Gang¹; CUI Yaping¹; GAO Meng¹; LI Xilong¹; MIAO Changhong²; LU Xihua¹

1.Department of Anesthesiology and Perioperative Medicine,the Affiliated Tumor Hospital of Zhengzhou University,Henan Zhengzhou 450003,China;2.Department of Anesthesiology,the Affiliated Zhongshan Hospital of Fudan University,Shanghai 200032,China.

Keywords:

pulmonary carcinoma; hydromorphone; elderly; hemodynamics; stress response; awaking quality

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2024.09.022

Abstract:

Objective:To explore the effects of general anesthesia with different doses of hydromorphone on hemodynamics,stress response and awaking quality in elderly patients undergoing radical resection of pulmonary carcinoma.Methods:A total of 50 elderly patients undergoing radical resection of pulmonary carcinoma in our hospital were enrolled between January 2023 and July 2023.According to different doses of hydromorphone,they were divided into low-dose group(n=25) and high-dose group(n=25).During general anesthesia induction,low-dose group was given 0.04 mg/kg hydromorphone,while high-dose group was given 0.06 mg/kg hydromorphone.The hemodynamics indexes ［mean arterial pressure(MAP),heart rate(HR)］ immediately after entering the room(T0),at 30 min after the start of surgery(T1) and at the end of surgery(T2),stress response indexes at T0 and T1,anesthesia effect,awaking related indexes and the occurrence of adverse reactions were compared between the two groups.Results:At T0,T1 and T2,there was no significant difference in HR or MAP between the two groups(P＞0.05).The levels of renin,angiotensin Ⅱ and aldosterone at T1 were higher than those at T0 in both groups(P＜0.05),but there was no significant difference between the two groups(P＞0.05).The interval from induction to BIS ≤60 in low-dose group was longer than that in high-dose group(P＜0.05),but there was no significant difference in BIS value before intubation and remedial sedation rate between the two groups(P＞0.05).The complete recovery time of spontaneous respiration and recovery time of orientation in low-dose group were shorter than those in high-dose group(P＜0.05),but there was no significant difference in eye-opening time between the two groups(P＞0.05).The incidence of adverse reactions in low-dose group was lower than that in high-dose group(12.00% vs 36.00%,P＜0.05).Conclusion:General anesthesia induction with different doses of hydromorphone has good sedative effect in elderly patients during radical resection of pulmonary carcinoma,which can maintain the hemodynamic stability and reduce stress response.Compared with 0.06 mg/kg hydromorphone,general anesthesia with 0.04 mg/kg hydromorphone is more conducive to postoperative awaking,with higher safety.

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Memo

Memo:

河南省医学科技攻关计划项目（编号：LHGJ20200184）

Common functions

Last Update: 2024-03-29