|Table of Contents|

The application value of cervical liquid-based cell blocks combined with immunohistochemistry in cervical cancer screening

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 09
Page:
1678-1681
Research Field:
Publishing date:

Info

Title:
The application value of cervical liquid-based cell blocks combined with immunohistochemistry in cervical cancer screening
Author(s):
WANG Quanzhi1; SONG Jingjing1; ZHANG Hanzhe1; XUE Peiwen1; GUO Jinwei1; HE Quanzhong2
1.Department of Pathology,the First People's Hospital of Xinxiang,Henan Xinxiang 453003,China;2.Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Xinxiang Medical University,Henan Xinxiang 453003,China.
Keywords:
cervical cancer; cervical liquid-based cell blocks; liquid-based cytology; immunohistochemistry
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.09.018
Abstract:
Objective:To investigate the application value of cervical liquid-based cell blocks combined with immunohistochemistry (IHC) in cervical cancer screening.Methods:Cell blocks were prepared,paraffin-embedded,and subjected to immunohistochemical staining from 239 cases with dual-positive results for HPV and cervical liquid-based cytology.The pathological and immunophenotypic characteristics were observed and analyzed for their application value.Results:Among the 90 cases diagnosed with atypical squamous cells of undetermined significance (ASC-US) by liquid-based cytology,cell block re-diagnosis revealed 39 cases of low-grade squamous intraepithelial lesions (LSIL),17 cases of high-grade squamous intraepithelial lesions (HSIL),1 case of cervical adenocarcinoma,and 33 cases of inflammation/no intraepithelial lesion.Among the 87 cases diagnosed with LSIL by cytology,cell block re-diagnosis showed 79 cases of LSIL and 8 cases of inflammation/no intraepithelial lesion.In 20 cases with cytological diagnosis of atypical squamous cells not excluding neoplastic lesions (ASC-H),cell block re-diagnosis revealed 2 cases of LSIL,15 cases of HSIL,1 case of squamous cell carcinoma (SCC),and 2 cases of inflammation/no intraepithelial lesion.Among the 32 cases diagnosed with HSIL by liquid-based cytology,cell block re-diagnosis showed 24 cases of HSIL,6 cases of SCC,and 2 cases of inflammation/no intraepithelial lesion.Among the 10 cases diagnosed with atypical glandular cells (AGC) by liquid-based cytology,cell block re-diagnosis revealed 2 cases of invasive cervical adenocarcinoma and 1 case of endometrial carcinoma.Conclusion:Cervical liquid-based cell blocks combined with IHC have excellent application value in cervical lesion and cervical cancer screening.They can effectively triage cases with unclear diagnoses in cytology,thereby improving the accuracy of cervical lesion diagnosis.They are a valuable supplement to cervical liquid-based cytology and HPV testing.

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Last Update: 2024-03-29