|Table of Contents|

Transformation of breast invasive ductal carcinoma to metaplasia squamous cell carcinoma after neoadjuvant chemotherapy:A case report and literature review

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 09
Page:
1638-1642
Research Field:
Publishing date:

Info

Title:
Transformation of breast invasive ductal carcinoma to metaplasia squamous cell carcinoma after neoadjuvant chemotherapy:A case report and literature review
Author(s):
QIN YapingFU YueXIAO ChurongWU JinfengTANG JuanCHEN LingfengXIAO Shengjun
Department of Pathology,the Second Affiliated Hospital,Guilin Medical University,Guangxi Guilin 541199,China.
Keywords:
breast neoplasmsinvasive ductal carcinomametaplastic breast carcinomametaplasia squamous cell carcinomaneoadjuvant chemotherapy
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.09.011
Abstract:
Objective:To explore the clinicopathological features of invasive breast ductal carcinoma cases,which transformated to metaplasia squamous cell carcinoma (MSCC) after neoadjuvant chemotherapy.Methods:A case of primary breast invasive ductal carcinoma with primary tumor pathological complete response (pCR) and axillary lymph node metastasis lesion transformed to MSCC after neoadjuvant chemotherapy was reported.Related literatures were reviewed to summarize clinicopathological characters.Results:The case reported here idiagnosis as invasive ductal carcinoma of the breast,focal squamous metaplasia observed in axillary lymph node metastases.The primary lesions were pathologically complete responds after neoadjuvant chemotherapy and axillary lymph node metastases were completely converted to MSCC.Imaging diagnosisdocumented cystic changes in the lymph nodes.HE showed that the cyst cavity was lined with stratified squamous epithelium,the morphology of which was consistent with well-differentiated squamous cell carcinoma.Immunohistochemical staining defined this case as a triple negative molecular subtype-ER,PR,HER2 negative.Sevencases (including 6 cases reported in the literature and the case reported here) were rerospective analysised.Before neoadjuvant chemotherapy,all cases diagnosed as invasive ductal carcinoma with the median age of 56 years,5 as primary and 2 as recurrent cases,among them 4 showed lymph node metastasis.The molecular subtype of most cases was triple-negative breast cancer (5/7).All 7 cases were transformed into MSCC after neoadjuvant chemotherapy.Among them,1 case (our reported case) showed that the primary lesion undergo pCR.Among 5 cases with lymph node metastases,1 case was pCR,3 cases were converted to MSCC,and 1 case was not transformed.Conclusion:Neoadjuvant chemotherapy could induce the transformation of invasive ductal carcinoma into MSCC.These cases have the unique clinicopathological features.Exploring the underlying molecular mechanisms of this transformationis significant for clinical individualized treatment and prognostic evaluation.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81760491,82060500,82260476);国家自然科学基金项目(编号:81760491,82060500,82260476);广西自然科学基金项目(编号:2020GXNSFAA159040);广西高校中青年教师科研基础能力提升项目(编号:2023KY0507)
Last Update: 2024-03-29