|Table of Contents|

Clinical and cytopathologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 09
Page:
1627-1631
Research Field:
Publishing date:

Info

Title:
Clinical and cytopathologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features
Author(s):
YANG Qiao1; WANG Pei2; GUO Ying1; LIU Tantan3; 4
1.Department of Pathology,Xi'an Daxing Hospital,Shaanxi Xi'an 710016,China；2.Department of Pathology,Weinan Central Hospital,Shaanxi Weinan 714000,China；3.Department of Pathology,the First Affiliated Hospital of Air Force Medical University (Xijing Hospital),Shaanxi Xi'an 710032,China;4.Northwest Women's and Children's Hospital,Shaanxi Xi'an 710061,China.
Keywords:
NIFTP; cytologic diagnosis; differential diagnosis; FNA
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2024.09.009
Abstract:
Objective:To investigate the cytological and pathological features,diagnosis and differential diagnosis,treatment,prognosis and molecular characteristics of cytological samples,which were obtained by ultrasound-guided fine-needle aspiration (FNA) and diagnosed as noninvasive follicular thyroid neoplasm with papillary-like nuclear features（NIFTP）postoperatively.Methods:We had screened 6 cases diagnosed as suspected malignant tumor by cytology and diagnosed as NIFTP through operation from the database.Each case was made into conventional smears and liquid-based smears,and stained by the HE and Papanicolaouataining respectively.And the cytopathologic features were reassessed and summarized by two senior cytopathologist in combination with related literature review.Results:Although the cytological features of NIFTP overlapped with papillary thyroid carcinoma（PTC） to some extent microscopically (both of them presented with enlarged,ground-glass like nuclei and prominent longitudinal grooves),we found that they were different from PTC in some respects.The former showed microfollicular-patterned cells distributed in sheets or scattered single microfollicles without papillary structure formed.In addition that,NIFTP had round nuclei,smooth nuclear membranes and rare pseudoinclusion bodies.Conclusion:Six FNA cytological samples of NIFTP were selected,and the clinical features,cytopathological features,differential diagnosis,treatment,prognosis and molecular characteristics of the patients were reanalyzed.Although it is very challenging,we found some diagnostic clues between NIFTP and other thyroid tumors in FNA samples,which may be helpful for cytopathologists to make accurate diagnosis and guide clinicians to select appropriate treatment and evaluate prognosis for patients.

References:

［1]NIKIFOROV YE,SEETHALA RR,TALLINI G,et al.Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma:A paradigm shift to reduce overtreatment of indolent tumors［J］．JAMA Oncol,2016,2(8):1023-1029．
［2]胡佐鸿，赵春.NIFTP的细针吸取细胞学研究进展［J］.诊断病理学杂志,2020，27(11):826-830. HU ZH,ZHAO C.Advances in fine needle aspiration cytology of NIFTP［J］.J Diag Pathol,2020,27（11）:826-830.
［3]RICARDO V LIOYD,ROBERT Y OSAMURA,GUNTER KLOPPEL,et al.WHO classification of tumours of endocrine organs［M］.Vol 10.4th ed.Lyon,France:WHO/IARC Press,2017：78-80.
［4]ZUBAIR W BALOCH,SYLVIA L ASA,JUSTINE A BARLETTA,et al.Overview of the 2022 WHO classification of thyroid neoplasms［J］.Endocr Pathol,2022,33(1):27-63.
［5]SYED Z ALI,EDMUND S CIBAS,ERIK K ALEXANDER,et al.The bethesda system for reporting thyroid cytopathology:Definitions,criteria,and explanatory notes［M］.New York:Springer,2018:72-74.
［6］刘志艳.具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤及其诊断标准［J］.中华病理学杂志,2017,46(3):205-208. LIU ZY.Non-invasive follicular thyroid tumor with papillary-like nucleus features and standard of diagnosis［J］.Chin J Pathol,2017,46(3):205-208.
［7]ANDREY BYCHKOV,CHAN KWON JUNG,ZHIYAN LIU,et al.Noninvasive follicular thyroid neoplasm with papillary-like nuclear features in Asian practice:Perspectives for surgical pathology and cytopathology［J］.Endocrine Pathology,2018,29:276-288.
［8]IVANA KHOLOVA,ELINA HAAGA,JAROSLAV LUDVIK,et al.Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP):Tumour entity with a short history.A review on challenges in our microscopes,molecular and ultrasonographic profile［J］.Diagnostics,2022,12:250.
［9]BONGIOVANNI M,GIOVANELLA L,ROMANELLI F,et al.Cytological diagnoses associated with noninvasive follicular thyroid neoplasms with papillary-like nuclear features according to the bethesda system for reporting thyroid cytopathology:a systematic review and meta-analysis［J］.Thyroid,2019,29(2):222-228.
［10]ZHANG Z，CHHIENG D，HARSHAN M,et al.Cytological features of noninvasive follicular thyoid neoplasm with papillarylike nuclear features［J］.J Am Soc Cytopathol，2019,8(1):5-10.
［11]NIKIFOROV YE，BALOCH ZW，HODAK SP,et al.Change in diagnostic criteria for noninvasive follicular thyoid neoplasm with papillarylike nuclear features［J］.JAMA Oncol，2018,4（8）：1125-1126.
［12]王艺超，向利娟，周萍，等.伴乳头状癌核特征的非浸润性滤泡性甲状腺肿瘤的分子研究进展［J］.中国普外基础与临床杂志,2019,26(1):110-115. WANG YC,XIANG LJ,ZHOU P,et al.The molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features［J］.Chinese Journal of Bases and Clinics in General Surgery,2019,26(1):110-115.
［13]BORRELLI N,DENARO M,UGOLINI C,et al.MiRNA expression profiling of 'noninvasive follicular thyroid neoplasms with papillary-like nuclear features' compared with adenomas and infiltrative follicular variants of papillary thyroid carcinomas［J］.Mod Pathol,2017,30(1):39-51.
［14]KLAUDIA ZAJKOWSKA,JANUSZ KOPCZYNSKI,STANISLAW GOZDZ,et al.Noninvasive follicular thyroid neoplasm with papillary-like nuclear features:a problematic entity［J］.Endocr Connect,2020,9(3):R47-R58.
［15]ALI SZ,BALOCH ZW,COCHAND-PRIOLLET B,et al.The 2023 Bethesda system for reporting thyroid cytopathology［J］.Thyroid,2023,33(9):1039-1044.
［16]FU G,POLYAKOVA O,MACMILLAN C,et al.Programmed death-ligand 1 expression distinguishes invasive encapsulated follicular variant of papillary thyroid carcinoma from noninvasive follicular thyroid neoplasm with papillary-like nuclear features［J］.E Bio Medicine,2017,18:50-55.
［17]HEE YOUNG NA,SO YEON PARK.Noninvasive follicular thyroid neoplasm with papillary-like nuclear features:its updated diagnostic criteria,preoperative cytologic diagnoses and impact on the risk of malignancy［J］.Journal of Pathology and Translational Medicine,2022,56(6):319-325.
［18]焦琼,刘志艳.第3版甲状腺细胞病理Bethesda报告系统解读［J］.中华医学杂志,2023,103(41):3238-3244. JIAO Q,LIU ZY.Interpretation of the third edition Bethesda system for reporting thyroid cytopathology［J］.Natl Med J China,2023,103(41):3238-3244.

Memo

Memo:
-
Last Update: 2024-03-29