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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 08

Page:

1435-1439

Research Field:

Publishing date:

Info

Title:

Clinicopathologic analysis of secretory carcinoma of the salivary gland and literature review (4 cases)

Author(s):

BAO Xinran¹; XU Xiaoyan²; MA Ping³; YANG Yihang¹; MENG Tingfang¹

1.College of Basic Medical Sciences,Inner Mongolia Medical University,Inner Mongolia Hohhot 010000,China;2.Department of Pathology,College of Basic Medical Sciences,Inner Mongolia Medical University,Inner Mongolia Hohhot 010000,China;3.Department of Stomatology,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Hohhot 010000,China.

Keywords:

salivary gland; secretory carcinoma; pathological features

PACS:

R739.8

DOI:

10.3969/j.issn.1672-4992.2024.08.011

Abstract:

Objective:To study and investigate the clinicopathological features,immunophenotype,differential diagnosis,treatment and prognosis of secretory carcinoma (SC) of the salivary gland.Methods:HE staining and immunohistochemical staining were performed on 4 cases of secretory carcinoma of the salivary gland,and clinical data of the 4 cases were collected and analyzed,and the relevant literature was reviewed.Results:All four cases occurred in the parotid gland,and the patients' age was 30 years old~55 years old,with a median age of 40 years old.Tumor diameters was 0.5 cm~3.0 cm.Tumor tissues were well-defined,with two cases having mostly solid gray-white cut surface and medium texture.One case had solid cut surface,mixed with gray-pink and gray-yellow,and soft and friable texture.One case showed cystic solid change,with soft gray-pink texture in the solid area.Microscopically,the tumor cells were arranged into multiple structures,including microcysts,macrocapsules and papillae within the glandular ducts.The tumor cells were poorly defined,with abundant cytoplasm,eosinophilic or vacuolated,with round or ovoid nuclei,obvious nucleoli,and rare nuclear fission and necrosis.In tumor cells of 4 cases,the expressions of CK5/6 and p63 were negative,and S100 and Mammaglobin were diffusely and strongly expressed,and CKAE1/AE3,CK7,CK8,Vimentin were diffusely expressed.The expression of DOG1 was absent in most of the tumor areas,and only weakly positive in a few peritumor nests or luminal margins,while Ki67 proliferation index was about 10%.Conclusion:Secretory carcinoma in the salivary gland is similar to secretory carcinoma in the breast and is a rare low-grade malignant tumor,which can be diagnosed due to its typical morphological features and combined with immunohistochemical results.ETV6-NTRK3 gene test can assist in the diagnosis,and the treatment is mainly surgical resection supplemented with chemoradiotherapy,with a good prognosis.

References:

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Memo

Memo:

内蒙古自治区自然科学基金项目（编号：2021LHMS08037）

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