«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 07

Page:

1366-1369

Research Field:

Publishing date:

Info

Title:

Research progress on the effect and mechanism of Apelin in the occurrence and development of ovarian cancer

Author(s):

WANG Huan; HAN Yimin

Department of Gynecology,Affiliated Tumor Hospital of Harbin Medical University,Heilongjiang Harbin 150081,China.

Keywords:

Apelin; ovarian cancer; occurrence and development

PACS:

R737.31

DOI:

10.3969/j.issn.1672-4992.2024.07.033

Abstract:

Apelin,a kind of adipocytokine,was first isolated and identified from bovine stomach extracts,which participates in biological functions such as anti-inflammatory,angiogenesis and fluid balance and is closely related to the occurrence and development of tumors.Apelin is expressed in ovarian cells and participates in the regulation of hormones related to ovarian function,and is also a key component in regulating the growth of follicles.Apelin can up-regulate the expression of Bcl-2 and down-regulate the expression of Bax to inhibit the apoptosis of ovarian cancer cells.Apelin plays an important role in tumor angiogenesis which can be inhibited by blocking Apelin /APJ signaling pathway.Apelin is considered to be a new mitotic peptide in endothelial cells,which can promote cell transition from G0/G1 to S phase and stimulate epithelial cell proliferation.In addition,Apelin has been shown to be an anti-apoptotic peptide,so blocking the Apelin /APJ signaling pathway can promote apoptosis of tumor cells.The etiology of ovarian cancer may be related to hormone levels such as estrogen or insulin-like growth factor-1,gynecological diseases such as endometriosis and fertility factors such as the persistent ovulation hypothesis.This article summarized the correlation between apelin and the development of ovarian cancer.

References:

£Û1£ÝTATEMOTO K,HOSOYA M,HABATA Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor£ÛJ£Ý.Biochem Biophys Res Commun,1998,251(2):471-476.
£Û2£ÝCASTAN-LAURELL I,DRAY C,ATTANE C,et al.Apelin,diabetes,and obesity£ÛJ£Ý.Endocrine,2011,40(1):1-9.
£Û3£ÝKUROWSKA P,BARBE A,ROZYCKA M,et al.Apelin in reproductive physiology and pathology of different species:A critical review£ÛJ/OL£Ý.Int J Endocrinol,2018:9170480£Û2020-10-20£Ý.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011052/.DOI:10.1155/2018/9170480.
£Û4£ÝCHAPMAN NA,DUPRE DJ,RAINEY JK.The apelin receptor:physiology,pathology,cell signalling,and ligand modulation of a peptide-activated class A GPCR£ÛJ£Ý.Biochem Cell Biol£¬2014,92£¨6£©:431-440.
£Û5£ÝCHEN J,LI Z,ZHAO Q,et al.Roles of Apelin/APJ system in cancer:Biomarker,predictor,and emerging therapeutic target£ÛJ£Ý.J Cell Physiol,2022,237(10):3734-3751.
£Û6£ÝMASOUMI J,JAFARZADEH A,KHORRAMDELAZAD H,et al.Role of Apelin/APJ axis in cancer development and progression£ÛJ£Ý.Adv Med Sci,2020,65(1):202-213.
£Û7£ÝSTEPIE¦r S,OLCZYK P,GOLA J,et al.The role of selected adipocytokines in ovarian cancer and endometrial cancer£ÛJ£Ý.Cells,2023,12(8):1118.
£Û8£ÝMUNGENAST F,THALHAMMER T.Estrogen biosynthesis and action in ovarian cancer£ÛJ/OL£Ý.Frontiers in Endocrinology,2014,5:192£Û2020-10-20£Ý.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228918/.DOI:10.3389/fendo.2014.00192.
£Û9£ÝHOFFMANN M,GOGOLA J,PTAK A.Apelin abrogates the stimulatory effects of 17¦Â-estradiol and insulin-like growth factor-1 on proliferation of epithelial and granulosa ovarian cancer cell lines via crosstalk between APLNR and ER¦Á/IGF1R£ÛJ£Ý.Mol Biol Rep,2019,46(6):6325-6338.
£Û10£ÝROCHE J,RAME C,REVERCHON M,et al.Apelin (APLN) and Apelin receptor (APLNR) in human ovary:Expression,signaling,and regulation of steroidogenesis in primary human luteinized granulosa cells£ÛJ£Ý.Biol Reprod,2016,95(5):104.
£Û11£ÝBULUN SE,WAN Y,MATEI D.Epithelial mutations in endometriosis:Link to ovarian cancer£ÛJ£Ý.Endocrinology,2019,160(3):626-638.
£Û12£ÝRAK A,DRWAL E,RAME C,et al.Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways£ÛJ/OL£Ý.United States:Theriogenology,2017:126-135(2017-04-07)£Û2020-10-25£Ý.https://pubmed.ncbi.nlm.nih.gov/28532828/.DOI:10.1016/j.theriogenology.2017.04.014.
£Û13£ÝROCHE J,RAME C,REVERCHON M,et al.Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells£ÛJ£Ý.Reproduction,2017,153(5):589-603.
£Û14£ÝCUI RR,MAO DA,YI L,et al.Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways£ÛJ£Ý.Amino Acids,2010,39(5):1193-1200.
£Û15£ÝSHUANG L,JIDONG W,HONGJUAN P,et al.Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells£ÛJ£Ý.Clin Exp Obstet Gynecol,2016,43(3):409-413.
£Û16£ÝCHEN Q,HE Q,ZHUANG L,et al.IP10-CDR3 reduces the viability and induces the apoptosis of ovarian cancer cells by down-regulating the expression of Bcl-2 and caspase 3£ÛJ/OL£Ý.United Kingdom:Onco Targets and Therapy,2019:9697-9706(2019-11-14)£Û2020-11-05£Ý.https://pubmed.ncbi.nlm.nih.gov/32009802/.DOI:10.2147/OTT.S209757.
£Û17£ÝLOIZZI V,DEL VV,GARGANO G,et al.Biological pathways involved in tumor angiogenesis and bevacizumab based anti-angiogenic therapy with special references to ovarian cancer£ÛJ£Ý.Int J Mol Sci,2017,18(9):1967.
£Û18£ÝLV D,LI H,CHEN L.Apelin and APJ,a novel critical factor and therapeutic target for atherosclerosis£ÛJ£Ý.Acta Biochim Biophys Sin (Shanghai),2013,45(7):527-533.
£Û19£ÝHOU J,ZHONG T,GUO T,et al.Apelin promotes mesenchymal stem cells survival and vascularization under hypoxic-ischemic condition in vitro involving the upregulation of vascular endothelial growth factor£ÛJ£Ý.Exp Mol Pathol,2017,102(2):203-209.
£Û20£ÝJIANG Y,SUN X,KONG B,et al.Antiangiogenesis therapy in ovarian cancer patients:An updated meta-analysis for 15 randomized controlled trials£ÛJ£Ý.Medicine (Baltimore),2018,97(34):e11920.
£Û21£ÝMONK BJ,MINION LE,COLEMAN RL.Anti-angiogenic agents in ovarian cancer:past,present,and future£ÛJ£Ý.Ann Oncol,2016,27(Suppl 1):i33-i39.
£Û22£ÝWALSH CS.Latest clinical evidence of maintenance therapy in ovarian cancer£ÛJ£Ý.Curr Opin Obstet Gynecol,2020,32(1):15-21.
£Û23£ÝLIU MC,TEWARI KS.Anti-angiogenesis therapy,synthetic lethality,and checkpoint inhibition in ovarian cancer:state of the science and novel combinations£ÛJ/OL£Ý.Drugs Context,2018,7:212558£Û2020-11-15£Ý.https://pubmed.ncbi.nlm.nih.gov/30627206/.DOI:10.7573/dic.212558.
£Û24£ÝHOFFMANN M,FIEDOR E,PTAK A.Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism£ÛJ/OL£Ý.Netherlands:Toxicol Lett,2017:15-22.(2017-01-19) £Û2020-11-20£Ý.https://www.ixueshu.com/document/829f0dd3432026fc318947a18e7f9386.html.DOI:10.1016/j.toxlet.2017.01.006.
£Û25£ÝZUURBIER L,RAHMAN A,CORDES M,et al.Apelin:A putative novel predictive biomarker for bevacizumab response in colorectal cancer£ÛJ£Ý.Oncotarget,2017,8(26):42949-42961.
£Û26£ÝWANG Z,WANG F,ZHONG J,et al.Using apelin-based synthetic notch receptors to detect angiogenesis and treat solid tumors£ÛJ£Ý.Nat Commun,2020,11(1):2163.
£Û27£ÝKARIMABAD MN,MAHMOODI M,JAFARZADEH A,et al.Molecular targets,anti-cancer properties and potency of synthetic indole-3-carbinol derivatives£ÛJ£Ý.Mini Rev Med Chem,2019,19(7):540-554.
£Û28£ÝCASTRO-MANRREZA ME.Participation of mesenchymal stem cells in the regulation of immune response and cancer development£ÛJ£Ý.Bol Med Hosp Infant Mex,2016£¬73(6):380-387.
£Û29£ÝZHOU L,XIANG J,LI L,et al.Effect of umbilical cord mesenchymal stem cells on proliferation and apoptosis of ovarian cancer cells£ÛJ£Ý.J Cent S Univ Med Sci,2019,44(10):1120-1127.
£Û30£ÝDOGRA S,NEELAKANTAN D,PATEL MM,et al.Apelin/APJ pathway promotes peritoneal dissemination of ovarian cancer cells by regulating lipid metabolism£ÛJ£Ý.Mol Cancer Res,2021,19(9):1534-1545.
£Û31£ÝOZKAN ZS,CILGIN H,SIMSEK M,et al.Investigation of Apelin expression in endometriosis£ÛJ£Ý.J Reprod Infertil,2013,14(2):50-55.
£Û32£ÝFENG M,YAO G,YU H,et al.Tumor apelin,not serum apelin,is associated with the clinical features and prognosis of gastric cancer£ÛJ£Ý.BMC Cancer,2016,16(1):794.
£Û33£ÝHU D,ZHU WF,SHEN WC,et al.Expression of Apelin and snail protein in breast cancer and their prognostic significance£ÛJ£Ý.Chinese Journal of Pathology,2018,47(10):743-746.

Memo

Memo:

-

Common functions

Last Update: 2024-02-29