［1］DE VISSER KE,JOYCE JA.The evolving tumor microenvironment:From cancer initiation to metastatic outgrowth［J］.Cancer Cell,2023,41(3):374-403.
［2］YIP R,RIMES JS,CAPALDO BD,et al.Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis［J］.Nat Commun,2021,12(1):6920.
［3］LIN D,SHEN L,LUO M,et al.Circulating tumor cells:biology and clinical significance［J］.Signal Transduct Target Ther,2021,6(1):404.
［4］PEREIRA-VEIGA T,SCHNEEGANS S,PANTEL K,et al.Circulating tumor cell-blood cell crosstalk:Biology and clinical relevance［J］.Cell Rep,2022,40(9):111298.
［5］CHEN X,SONG E.The theory of tumor ecosystem［J］.Cancer Commun (Lond),2022,42(7):587-608.
［6］GALLI F,AGUILERA JV,PALERMO B,et al.Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy［J］.J Exp Clin Cancer Res,2020,39(1):89.
［7］WU F,FAN J,HE Y,et al.Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer［J］.Nat Commun,2021,12(1):2540.
［8］GAO Y,ROSEN JM,ZHANG XH.The tumor-immune ecosystem in shaping metastasis［J］.Am J Physiol Cell Physiol,2023,324(3):C707-C717.
［9］BAGHBAN R,ROSHANGAR L,JAHANBAN-ESFAHLAN R,et al.Tumor microenvironment complexity and therapeutic implications at a glance［J］.Cell Commun Signal,2020,18(1):59.
［10］SIMIONI C,CONTI I,VARANO G,et al.The complexity of the tumor microenvironment and its role in acute lymphoblastic leukemia:Implications for therapies［J］.Front Oncol,2021,11:673506.
［11］YANG L,LI A,LEI Q,et al.Tumor-intrinsic signaling pathways:key roles in the regulation of the immunosuppressive tumor microenvironment［J］.J Hematol Oncol,2019,12(1):125.
［12］PETERS JM,GONZALEZ FJ.The evolution of carcinogenesis［J］.Toxicol Sci,2018,165(2):272-276.
［13］CILIBRASI C,PAPANASTASOPOULOS P,SAMUELS M,et al.Reconstituting immune surveillance in breast cancer:Molecular pathophysiology and current immunotherapy strategies［J］.Int J Mol Sci,2021,22(21):1-20.
［14］WU Y,BISWAS D,SWANTON C.Impact of cancer evolution on immune surveillance and checkpoint inhibitor response［J］.Semin Cancer Biol,2022,84:89-102.
［15］WEN Y,ZHU Y,ZHANG C,et al.Chronic inflammation,cancer development and immunotherapy［J］.Front Pharmacol,2022,13:1040163.
［16］CHAKRABORTY C,SHARMA AR,SHARMA G,et al.The interplay among miRNAs,major cytokines,and cancer-related inflammation［J］.Mol Ther Nucleic Acids,2020,20:606-620.
［17］SCHMITT M,GRETEN FR.The inflammatory pathogenesis of colorectal cancer［J］.Nat Rev Immunol,2021,21(10):653-667.
［18］CAO L,ZHANG S,YAO D,et al.Comparative analyses of the prognosis,tumor immune microenvironment,and drug treatment response between left-sided and right-sided colon cancer by integrating scRNA-seq and bulk RNA-seq data［J］.Aging (Albany NY),2023,15(14):7098-7123.
［19］CASANOVA-ACEBES M,DALLA E,LEADER AM,et al.Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells［J］.Nature,2021,595(7868):578-584.
［20］FOSTER DS,JANUSZYK M,DELITTO D,et al.Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin［J］.Cancer Cell,2022,40(11):1392-1406.
［21］YAMAMOTO Y,KASASHIMA H,FUKUI Y,et al.The heterogeneity of cancer-associated fibroblast subpopulations:Their origins,biomarkers,and roles in the tumor microenvironment［J］.Cancer Sci,2023,114(1):16-24.
［22］LI X,MU P.The critical interplay of CAF plasticity and resistance in prostate cancer［J］.Cancer Res,2023,83(18):2990-2992.
［23］SIMON T,SALHIA B.Cancer-associated fibroblast subpopulations with diverse and dynamic roles in the tumor microenvironment［J］.Mol Cancer Res,2022,20(2):183-192.
［24］QING X,XU W,LIU S,et al.Molecular characteristics,clinical significance,and cancer immune interactions of angiogenesis-associated genes in gastric cancer［J］.Front Immunol,2022,13:843077.
［25］WECHMAN SL,EMDAD L,SARKAR D,et al.Vascular mimicry:Triggers,molecular interactions and in vivo models［J］.Adv Cancer Res,2020,148:27-67.
［26］YE X,HUANG X,FU X,et al.Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis［J］.J Hematol Oncol,2023,16(1):46.
［27］ALMAHMOUDI R,KASANEN M,SIEVILAINEN M,et al.Prognostic value of blood and lymphatic vessel markers in tongue cancer:A systematic review［J］.Cancer Sci,2019,110(11):3424-3433.
［28］MAO X,XU J,WANG W,et al.Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment:New findings and future perspectives［J］.Mol Cancer,2021,20(1):131.
［29］CHEN YC,LI H,WANG J.Mechanisms of metformin inhibiting cancer invasion and migration［J］.Am J Transl Res,2020,12(9):4885-4901.
［30］NOVIKOV NM,ZOLOTARYOVA SY,GAUTREAU AM,et al.Mutational drivers of cancer cell migration and invasion［J］.Br J Cancer,2021,124(1):102-114.
［31］ZAVYALOVA MV,DENISOV EV,TASHIREVA LA,et al.Intravasation as a key step in cancer metastasis［J］.Biochemistry (Mosc),2019,84(7):762-772.
［32］SZNURKOWSKA MK,ACETO N.The gate to metastasis:Key players in cancer cell intravasation［J］.FEBS J,2022,289(15):4336-4354.
［33］HELDWEIN MB,DOERR F,SCHLACHTENBERGER G,et al.Lymphangiosis carcinomatosa independently affects long-term survival of non-small cell lung cancer patients［J］.Surg Oncol,2021,37:101611.
［34］SATCHER RL,ZHANG XH.Evolving cancer-niche interactions and therapeutic targets during bone metastasis［J］.Nat Rev Cancer,2022,22(2):85-101.
［35］HUYNH M,CRANE MJ,JAMIESON AM.The lung,the niche,and the microbe:Exploring the lung microbiome in cancer and immunity［J］.Front Immunol,2022,13:1094110.
［36］DAVIDSON S,EFREMOVA M,RIEDEL A,et al.Single-cell RNA sequencing reveals a dynamic stromal niche that supports tumor growth［J］.Cell Rep,2020,31(7):107628.
［37］BALDOMINOS P,BARBERA-MOURELLE A,BARREIRO O,et al.Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche［J］.Cell,2022,185(10):1694-1708.
［38］PEREIRA-VEIGA T,SCHNEEGANS S,PANTEL K,et al.Circulating tumor cell-blood cell crosstalk:Biology and clinical relevance［J］.Cell Rep,2022,40(9):111298.
［39］DENG Z,WU S,WANG Y,et al.Circulating tumor cell isolation for cancer diagnosis and prognosis［J］.EBioMedicine,2022,83:104237.
［40］SCHUSTER E,TAFTAF R,REDUZZI C,et al.Better together: circulating tumor cell clustering in metastatic cancer［J］.Trends Cancer,2021,7(11):1020-1032.
［41］IDA S,TAKAHASHI H,TADA H,et al.Dynamic changes of the EMT spectrum between circulating tumor cells and the tumor microenvironment in human papillomavirus-positive head and neck squamous cell carcinoma［J］.Oral Oncol,2023,137:106296.
［42］LOWE SS,MILLIGAN C,BREARLEY SG.Activity and advanced cancer:A grounded theory［J］.Palliat Med,2020,34(2):231-244.
［43］KIM MY,OSKARSSON T,ACHARYYA S,et al.Tumor self-seeding by circulating cancer cells［J］.Cell,2009,139(7):1315-1326.
［44］KLOTZ R,THOMAS A,TENG T,et al.Circulating tumor cells exhibit metastatic tropism and reveal brain metastasis drivers［J］.Cancer Discov,2020,10(1):86-103.
［45］KURMA K,ALIX-PANABIERES C.Mechanobiology and survival strategies of circulating tumor cells:a process towards the invasive and metastatic phenotype［J］.Front Cell Dev Biol,2023,11:1188499.
［46］YADAVALLI S,JAYARAM S,MANDA SS,et al.Data-driven discovery of extravasation pathway in circulating tumor cells［J］.Sci Rep,2017,7:43710.
［47］LOZAR T,GERSAK K,CEMAZAR M,et al.The biology and clinical potential of circulating tumor cells［J］.Radiol Oncol,2019,53(2):131-147.
［48］MICALIZZI DS,MAHESWARAN S,HABER DA.A conduit to metastasis:circulating tumor cell biology［J］.Genes Dev,2017,31(18):1827-1840.
［49］HEN O,BARKAN D.Dormant disseminated tumor cells and cancer stem/progenitor-like cells:Similarities and opportunities［J］.Semin Cancer Biol,2020,60:157-165.
［50］PENG L,ZHANG Y,WANG Z.Immune responses against disseminated tumor cells［J］.Cancers (Basel),2021,13(11):2515-2531.
［51］RISSON E,NOBRE AR,MAGUER-SATTA V,et al.The current paradigm and challenges ahead for the dormancy of disseminated tumor cells［J］.Nat Cancer,2020,1(7):672-680.
［52］CHARPENTIER M,SPADA S,VAN NEST SJ,et al.Radiation therapy-induced remodeling of the tumor immune microenvironment［J］.Semin Cancer Biol,2022,86(Pt 2):737-747.
［53］BENAVENTE S,SANCHEZ-GARCIA A,NACHES S,et al.Therapy-induced modulation of the tumor microenvironment:New opportunities for cancer therapies［J］.Front Oncol,2020,10:582884.
［54］CHIBAYA L,SNYDER J,RUSCETTI M.Senescence and the tumor-immune landscape:Implications for cancer immunotherapy［J］.Semin Cancer Biol,2022,86(Pt 3):827-845.