«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 07

Page:

1327-1331

Research Field:

Publishing date:

Info

Title:

Value of 18F-FDG PET/CT in the differential diagnosis of multisystemic sarcoidosis from diffuse large B-cell lymphoma

Author(s):

HUI Jinzi¹; 2; WEI Yixin²; SHI Xiaorui¹; DING Ze'en¹; QU Yang¹; LI Qian¹; YUAN Menghui²; XU Jianlin¹; SHI Changbei¹; YANG Shengli¹

1.Department of Nuclear Medicine,Shaanxi Provincial Cancer Hospital,Shaanxi Xi'an 710061,China;2.Department of Nuclear Medicine,the Second Hospital Affiliated to Air Force Medical University,Shaanxi Xi'an 710024,China.

Keywords:

sarcoidosis; diffuse large B-cell lymphoma; 18F-FDG; PET/CT; differential diagnosis

PACS:

R733.4

DOI:

10.3969/j.issn.1672-4992.2024.07.025

Abstract:

Objective:To compare and analyze the difference of 18F-FDG PET/CT imaging features between multiple system sarcoidosis and diffuse large B-cell lymphoma (DLBCL),and to explore the value of 18F-FDG PET/CT in the differential diagnosis of the two.Methods:A total of 15 cases of sarcoidosis and 39 cases of DLBCL,newly diagnosed in the Second Affiliated Hospital of Air Force Medical University from July 2018 to July 2023,were retrospectively analyzed.Clinicopathological data and 18F-FDG PET/CT imaging data of the patients were collected.The imaging features,the areas of involvement,the lymph node features,the maximum diameter of the lesion and the semi-quantitative parametar maximum standardized uptake value£¨SUVmax£© of the two groups were compared and analyzed.Results:Sarcoidosis was characterized by symmetrical involvement of mediastinum and hilar lymph nodes without a tendency of fusion,and bilateral lungs/pleura were easily involved.DLBCL lymph nodes were prone to coalesce and extranodal invasion of gastrointestinal tract.The incidence of mediastinum,hilar lymph nodes,double lungs and pleura in sarcoidosis group was higher than that in DLBCL group,and DLBCL was prone to gastrointestinal involvement (all P£¼0.05).The incidence of lymph node fusion was lower in the sarcoidosis group than in the DLBCL group (P£¼0.05).There was no significant difference in lymph node necrosis rate and calcification rate between the two groups (all P£¾0.05).The maximum lymph node diameter in the sarcoidosis group was (2.40¡À0.71) cm,which was lower than that in the DLBCL group (6.50¡À2.53) cm.The SUVmax in the sarcoidosis group was 8.12¡À4.15,which was lower than that in the DLBCL group (19.93¡À7.54) (all P£¼0.05).Conclusion:18F-FDG PET/CT is of great value in the differential diagnosis of sarcoidosis and DLBCL.The combination of characteristic manifestations,involved location,lesion size,fusion trend and semi-quantitative parameter SUVmax can help to distinguish them.

References:

£Û1£ÝHENA KM.Sarcoidosis epidemiology:Race matters£ÛJ£Ý.Front Immunol,2020,11:537382.
£Û2£ÝS¦KVE P,PACHECO Y,DURUPT F,et al.Sarcoidosis:A clinical overview from symptoms to diagnosis£ÛJ£Ý.Cells,2021,10(4):766.
£Û3£ÝDRENT M,CROUSER ED,GRUNEWALD J.Challenges of sarcoidosis and its management£ÛJ£Ý.N Engl J Med,2021,385(11):1018-1032.
£Û4£ÝÖйú¿¹°©Ð­»áÁÜ°ÍÁöרҵίԱ»á£¬ÖйúҽʦЭ»áÖ×Áöҽʦ·Ö»á£¬ÖйúÒ½ÁƱ£½¡¹ú¼Ê½»Á÷´Ù½ø»áÖ×ÁöÄÚ¿Æ·Ö»á.ÖйúÁÜ°ÍÁöÖÎÁÆÖ¸ÄÏ(2021Äê°æ) £ÛJ£Ý.ÖлªÖ×ÁöÔÓÖ¾£¬2021£¬43(07):707-735. China Anti-cancer Association Lymphoma Committee,Chinese Association for Clinical Oncologists,Medical Oncology Branch of Chinese International Exchange and Promotion Association for Medical and Healthcare.Clinical practice guideline for lympoma in China (2021 edition) £ÛJ£Ý.Chinese Journal of Cancer,2021,43(07):707-735.
£Û5£ÝKRAAIJVANGER R,JANSSEN BON¦BS M,VORSELAARS ADM,et al.Biomarkers in the diagnosis and prognosis of sarcoidosis:Current use and future prospects£ÛJ£Ý.Front Immunol,2020,11:1443.
£Û6£ÝEERTINK JJ,VAN DE BRUG T,WIEGERS SE,et al.18F-FDG PET baseline radiomics features improve the prediction of treatment outcome in diffuse large B-cell lymphoma£ÛJ£Ý.Eur J Nucl Med Mol Imaging,2022,49(3):932-942.
£Û7£ÝÁõÑÞÇå,½¹úÐã,ºÂɺº÷,µÈ.18F -FDG PET/CTÔÚ¶àϵͳÐÔ½á½Ú²¡Õï¶ÏÖеÄÓ¦ÓüÛÖµ£ÛJ£Ý.ÏÖ´úÖ×Áöҽѧ,2022,30(14):2591-2595. LIU YQ£¬LU GX£¬HAO SH,et al.The value of 18F-FDG PET/CT in the diagnosis of multiple system sarcoidosis£ÛJ£Ý.Modern Oncology,2022,30(14):2591-2595.
£Û8£ÝÁõÇí,ºÎÈï,·½¶«,µÈ.Éñ¾­ÏµÍ³ÊÜÀÛ½á½Ú²¡18F-FDG PET/CTÏÔÏñ1Àý£ÛJ£Ý.ÖйúÁÙ´²Ò½Ñ§Ó°ÏñÔÓÖ¾,2022,33(07):524-526. LIU Q,HE R,FANG D,et al.18F-FDG PET/CT imaging was performed in 1 case of sarcoidosis with nervous system involvement£ÛJ£Ý.Chinese Journal of Clinical Medical Imaging,2022,33(07):524-526.
£Û9£ÝKEIJSERS RGM,GRUTTERS JC.In which patients with sarcoidosis is FDG PET/CT indicated£ÛJ£Ý.J Clin Med,2020,9(3):890.
£Û10£ÝCOTTEREAU AS,MEIGNAN M,NIOCHE C,et al.Risk stratification in diffuse large B-cell lymphoma using lesion dissemination and metabolic tumor burden calculated from baseline PET/CT£ÛJ£Ý.Ann Oncol,2021,32(3):404-411.
£Û11£ÝÖлªÒ½Ñ§»áºôÎü²¡Ñ§·Ö»á¼äÖÊÐԷμ²²¡Ñ§×飬ÖйúҽʦЭ»áºôÎüҽʦ·Ö»á¼äÖÊÐԷμ²²¡¹¤×÷ίԱ»á.Öйú·Î½á½Ú²¡Õï¶ÏºÍÖÎÁÆר¼Ò¹²Ê¶£ÛJ£Ý.Öлª½áºËºÍºôÎüÔÓÖ¾£¬2019£¬42(9):685-693. Interstitial Lung Disease Group,Chinese Thoracic Society,Chinese Medical Association,Interstitial Lung Disease Working Committee,Chinese Association of Chest Physicians,Chinese Medical Doctor Association.Chinese expert consensus on the diagnosis and treatment of pulmonary sarcoidosis£ÛJ£Ý.Chinese Journal of Tuberculosis and Respiratory,2019,42(9):685-693.
£Û12£ÝR¦IGIS C,BENALI K,ROUZET F.FDG PET/CT imaging of sarcoidosis£ÛJ£Ý.Semin Nucl Med,2023,53(2):258-272.
£Û13£ÝCROUSER ED,MAIER LA,WILSON KC,et al.Diagnosis and detection of sarcoidosis.An official American thoracic society clinical practice guideline£ÛJ£Ý.Am J Respir Crit Care Med,2020,201(8):e26-e51.
£Û14£ÝTETIKKURT C,YANARDAG H,SAYMAN BH,et al.Diagnostic utility of 68Ga-citrate and 18F-FDG PET/CT in sarcoidosis patients£ÛJ/OL£Ý.Monaldi Arch Chest Dis,2020,23,90(4)£Û2020-12-23£Ý.http://pubmed.ncbi.nlm.nih.gov/33372740/.Doi: 10.4081/monaldi.2020.1509.
£Û15£ÝGUPTA V,SINGH V,BAJWA R,et al.Site-specific survival of extra nodal diffuse large B-cell lymphoma and comparison with gastrointestinal diffuse large B-cell lymphoma£ÛJ£Ý.J Hematol,2022,11(2):45-54.
£Û16£ÝYU C,XIA X,QIN C,et al.Is SUVmax helpful in the differential diagnosis of enlarged mediastinal lymph nodes? A pilot study£ÛJ£Ý.Contrast Media Mol Imaging,2018,2018:3417190.
£Û17£Ýº«ÏþÓê,ºÂɺº÷,²Ü½£·å,µÈ.18·ú-·ú´úÍÑÑõÆÏÌÑÌÇPET/CT¶Ô¶àϵͳ½á½Ú²¡Õï¶Ï¼°ÓëÁÜ°ÍÁö¼ø±ðÕï¶Ï¼ÛÖµ·ÖÎö£ÛJ£Ý.ÁÙ´²¾üÒ½ÔÓÖ¾,2022,50(02): 170-172. HAN XY,HAO SH,CAO JF,et al.18F-deoxyglucose PET/CT for multisystem sarcoidosis analysis of differential diagnosis value with lymphoma£ÛJ£Ý.Clin J Med Offic,2022,50(02):170-172.
£Û18£ÝHAWKES EA,BARRACLOUGH A,SEHN LH.Limited-stage diffuse large B-cell lymphoma£ÛJ£Ý.Blood,2022,139(6):822-834.
£Û19£ÝÁºÓ¢¿ý,¹ù·é,ÕÅ´ºÑô,µÈ.18F-FDG PET/CT¶Ô¶àϵͳ½á½Ú²¡ÓëÁÜ°ÍÁöµÄ¼ø±ðÕï¶Ï¼ÛÖµ£ÛJ£Ý.ʵÓð©Ö¢ÔÓÖ¾,2012,27(03):266-269. LIANG YK,GUO F,ZHANG CY,et al.Clinical value of 18F-FDG PET/CT in the differential diagnosis between multiple systemic sarcoidosis and lymphoma£ÛJ£Ý.The Practical Journal of Cancer,2012,27(03):266-269£®
£Û20£ÝKA¦kIKOVI¦g LE¦gI¦g S,JAVORAC J,LOVRENSKI A,et al.Case report:Thyroid sarcoidosis as a rare localization of the disease: Report of two cases and review of the literature£ÛJ£Ý.Front Med (Lausanne),2023,10:1046420.
£Û21£ÝBENETTINI G,BRUSCHINI L,FIACCHINI G,et al.Nasopharyngeal sarcoidosis:case reports and literature review£ÛJ£Ý.Sarcoidosis Vasc Diffuse Lung Dis,2022,39(1):e2022010.

Memo

Memo:

ÉÂÎ÷Ê¡Ö×ÁöÒ½ÔºÔºÄÚ¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð·õÓýÏîÄ¿£¨±àºÅ£ºSC23A04£©

Common functions

Last Update: 2024-02-29