|Table of Contents|

Quantitative analysis of nutritional therapy during surgery and chemotherapy and its value for early evaluation of prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 07
Page:
1315-1320
Research Field:
Publishing date:

Info

Title:
Quantitative analysis of nutritional therapy during surgery and chemotherapy and its value for early evaluation of prognosis
Author(s):
ZHANG Zhen; WANG Donghao; LYU Yang
Tianjin Medical University Cancer Institute & Hospital，National Clinical Research Center for Cancer，Tianjin's Clinical Research Center for Cancer，Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China.
Keywords:
bioelectrical impedance analysis; tumor; phase angle; survival index; nutritional risk
PACS:
R730.53
DOI:
10.3969/j.issn.1672-4992.2024.07.023
Abstract:
Objective：Bioelectrical impedance analysis is utilized to assess various populations, enabling a comprehensive comprehension of body composition attributes among distinct groups. Moreover, it aids in the identification of effective and timely indicators for malnutrition warning and prognostic evaluation.Methods：The body composition of patients was determined by body composition analyzer,and body composition data of normal population was collected as the control group.The body composition data of tumor patients who could not eat in a short period after surgical treatment and relied on early enteral/parenteral nutrition therapy were classified as the operation group.The body composition data of tumor patients who recovered from the surgery group and underwent chemotherapy after discharge were classified as the chemotherapy group.The characteristics and trends of body composition in the three groups were analyzed,and the early warning indicators of patients with nutritional risk were sought through correlation analysis,and the indicators of early prognosis assessment and the optimal critical value were screened according to the receiver operating characteristic curve (ROC).Results：Compared with the control group,the phase angle and absolute survival coefficient of the surgical treatment group were decreased (P＜0.001).Compared with the control group,the protein content,skeletal muscle mass and phase Angle of the chemotherapy group were significantly decreased (P=0.002,P=0.001,P＜0.001),the absolute survival coefficient decreased (P＜0.001).The paired analysis before and after nutrition in the operation group found that the phase angle increased after nutrition treatment (P=0.004),and the absolute survival coefficient increased(P＜0.001).The correlation study found that the phase angle of patients before nutritional treatment after surgery and patients in chemotherapy group were significantly negatively correlated with SOFA score and NRS2002 score of nutritional screening (r=-0.480 8,P＜0.000 1;r=-0.543 4,P＜0.000 1),and the phase angle was negatively correlated with the survival coefficient (r=-0.674 5,P＜0.000 1). Univariate analysis showed that phase Angle and survival coefficient had a good advantage in predicting the length of hospital stay in the operation group (ROC-AUC 0.879,P＜0.001;ROC-AUC 0.843,P＜0.001),while SOFA score,phase Angle and survival coefficient were combined to predict the length of hospital stay,and the maximum area under the curve was 0.927, and the Yoden index was 0.751.Conclusion：The phase angle offers numerous advantages in predicting patients' nutritional risk and assessing the effectiveness of nutritional therapy.Additionally,it is significantly associated with the severity of the patient's condition and can effectively reflect the functional status of cells and organs.Moreover,both the phase angle and the absolute survival coefficient demonstrate a strong predictive value for determining the length of hospital stay in critically ill cancer patients undergoing surgical treatment.

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Memo

Memo:
天津市医学重点学科（专科）建设项目（编号：TJYXZDXK-009A）；天津市卫生健康科技项目（编号：TJWJ2022MS006）；天津医科大学肿瘤医院科研项目（编号：2107）
Last Update: 2024-02-29