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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 07

Page:

1311-1315

Research Field:

Publishing date:

Info

Title:

Effect of lidocaine combined with sufentanil for patient-controlled intravenous analgesia on pain and intestinal function recovery after radical resection of colorectal cancer

Author(s):

WU Yumin¹; ZHANG Senbing¹; YAN Wenjun²; ZHANG Wenjie¹; QU Song¹; TIAN Bin³

1.The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;2.Department of Anesthesiology,Gansu Provincial Hospital,Gansu Lanzhou 730000,China;3.Ningxia Medical University,Ningxia Yinchuan 750004,China.

Keywords:

lidocaine; colorectal cancer; pain; quality of recovery

PACS:

R735.3+7

DOI:

10.3969/j.issn.1672-4992.2024.07.022

Abstract:

Objective:To explore the analgesic effect of lidocaine combined with sufentanil for patient controlled intravenous analgesia (PCIA) after laparoscopic radical resection of colorectal cancer and its influence on the recovery of intestinal function.Methods:135 patients undergoing laparoscopic radical resection of colorectal cancer under general anesthesia were randomLy divided into the sufentanil group (Group S,n=68) and the lidocaine combined with sufentanil group (Group LS,n=67).The PCIA device was used for postoperative pain management.There was Group S (PCIA:Sufentanil 2.0 ¦Ìg/kg,ondansetron 16 mg,and 0.9% saline were added to make 300 mL) and Group LS (PCIA:lidocaine 48 mg/kg,sufentanil 2.0 ¦Ìg/kg,ondansetron 16 mg,and 0.9% saline were added to make 300 mL).The primary outcome was the VAS pain score at 6 h,12 h,24 h,36 h,and 48 h after operation.Secondary outcomes included the effective times of PCIA compression and the incidence of salvage analgesia within 48 h after operation,the time of first flatus and defecation after operation,the quality of recovery-15 (QoR-15) score,postoperative hospitalization time,the incidence of postoperative nausea and vomiting (PONV) within 48 h,and the incidence rate of adverse events of local anesthetic poisoning.Results:The VAS pain scores of patients in Group LS at 6 h,12 h,24 h,36 h,and 48 h after operation were significantly lower than those in Group S (P£¼0.05).The effective times of PCIA compression in Group LS within 48 h after operation were significantly lower than those in Group S (P£¼ 0.05).There was no statistical difference in the incidence of remedial analgesia within 48 h after operation between the two groups (P£¾0.05).The time of first flatus and defecation in Group LS was significantly earlier than that in Group S (P£¼0.05).There was no statistical difference in the preoperative QoR-15 score between the two groups (P£¾0.05).On the first and second days after operation,the QoR-15 score of Group LS was significantly higher than that of Group S (P£¼ 0.05).The postoperative hospitalization time in Group LS was significantly shorter than that in Group S (P£¼0.05).The incidence of PONV in Group LS was significantly lower than that in Group S (P£¼0.05).There were no adverse events related to local anesthetic poisoning in Group LS.Conclusion:Lidocaine combined with sufentanil PCIA can provide more effective postoperative analgesia for patients undergoing laparoscopic radical resection of colorectal cancer and accelerate the recovery of intestinal function.

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Memo

Memo:

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Last Update: 2024-02-29