|Table of Contents|

Relationship between NSUN2 expression and clinicopathological features and prognosis in renal clear cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 07
Page:
1295-1298
Research Field:
Publishing date:

Info

Title:
Relationship between NSUN2 expression and clinicopathological features and prognosis in renal clear cell carcinoma
Author(s):
ZHANG Yuan1; HU Wenbing2; ZHOU Qiang2; DU Tianxing2
1.Medical College,Wuhan University of Science and Technology,Hubei Wuhan 430081,China;2.Department of Oncology,Huangshi Central Hospital(Affiliated Hospital of Hubei Institute of Technology) Hubei Key Laboratory of Kidney Disease Intervention and Occurrence,Hubei Huangshi 435000,China.
Keywords:
renal clear cell carcinoma; NSUN2; immunohistochemistry; expression; prognosis
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2024.07.019
Abstract:
Objective:To detect the expression of NOP2/Sun RNA methyltransferase family member 2(NSUN2) in renal clear cell carcinoma(ccRCC) tissue and analyze its relationship with clinicopathological features and prognosis.Methods:A total of 95 ccRCC tissue wax specimens and 95 para-cancer tissue wax specimens were collected.Immunohistochemistry was used to detect the expression level of NSUN2 in the two groups,and the clinicopathological relationship between NSUN2 and ccRCC patients was analyzed.Kaplan-Meier survival analysis,Log-rank univariate analysis and Cox multivariate analysis were used to detect the correlation between NSUN2 expression and prognosis of ccRCC patients.Results:The high expression rate of NSUN2 in cancer tissues was 69.5%,and the high expression rate in para-cancer tissues was 15.8%,the difference between the two groups was statistically significant(P＜0.05).The high expression of NSUN2 was related to tumor size,histological grade,lymphatic metastasis and clinical stage(P＜0.05).Kaplan-Meier survival analysis and Cox regression model showed that the expression level of NSUN2 was associated with the prognosis of ccRCC.Conclusion:NSUN2 is highly expressed in ccRCC tissues,and is related to the clinicopathological features and prognosis of ccRCC,which could be used as an indicator of prognosis of ccRCC.

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Memo

Memo:
湖北省重点实验室开放基金项目(编号：SB202104)
Last Update: 2024-02-29