|Table of Contents|

The role of SOX10 in the pathologic diagnosis and differential diagnosis of ductal epithelial lesions of the breast

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 07
Page:
1260-1264
Research Field:
Publishing date:

Info

Title:
The role of SOX10 in the pathologic diagnosis and differential diagnosis of ductal epithelial lesions of the breast
Author(s):
CHEN Chunni; HUANG Xiaozhong; WANG Caihong; YANG Jun
Department of Pathology,the Second Affiliated Hospital of Xi'an Jiaotong University(Xibei Hospital),Shaanxi Xi'an 710004,China.
Keywords:
SOX10; breast; UDH; ADH; TNBC
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.07.013
Abstract:
Objective:To evaluate the expression of SOX10 in breast usual ductal hyperplasia(UDH),atypical hyperplasia(ADH),ductal carcinoma in situ(DCIS) and different subtypes of invasive ductal carcinoma.Methods:The expression of SOX10 in 197 cases of breast epithelial lesions(48 cases of UDH,20 cases of ADH,40 cases of DCIS,10 cases of apocrine carcinoma,20 cases of luminal A,27 cases of luminal B,10 cases of Her2 over-expression and 22 cases of triple-negative breast cancer it the second Affiliated Hospital of Xi'an Jiaotong University from December 2021to June 2023) was investigated by immunohistochemistry.Results:All UDH cases showed mosaic SOX10 expression,while all ADH and DCIS cases lacked expression(P＜0.001).SOX10 expression was identified in 68.20% triple-negative breast carcinoma(TNBC) cases,while it was not expressed in luminal A,luminal B,Her2 overesperssiong invisive breast cancer(P＜0.001).SOX10 was expressed in 86.67% of AR-TNBC,and only 28.75% of AR-TNBC,and was not expressed in apocrine carcinoma.The difference was statistically significant(P＜0.001).SOX10 was expressed in all normal breast periductal myoepithelium,while it was absent in 32.5%(13/40) of DCIS periductal myoepithelium.Conclusion:SOX10 immunohistochemical staining is an important indicator to identify UDH and ADH,but it cannot distinguish ADH and DCIS,and it can be lost in the myoepithelium of intraductal carcinomas,especially high-grade intraductal carcinomas,so it is risky to use it to identify DCIS and invasive carcinomas,especially minimally invasive breast carcinomas.SOX10 is a relatively specific indicator of TNBC carcinomas,and it is negatively correlated with the expression of AR.The immunohistochemical staining pattern of SOX10 is correctly read,and is helpful for us to identify the different ductal epithelial lesions in the breast better.

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Last Update: 2024-02-29