［1］RO S.Multi-phenotypic role of serum response factor in the gastrointestinal system［J］.J Neurogastroenterol Motil,2016,22(2):193-200.
［2］CHAI J,TARNAWSKI AS.Serum response factor:discovery,biochemistry,biological roles and implications for tissue injury healing［J］.J Physiol Pharmacol,2002,53(2):147-157.
［3］ROUPELIEVA M,GRIFFITHS SJ,KREMMER E,et al.Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex［J］.J Gen Virol,2010,91(Pt 5):1138-1149.
［4］MODAK C,CHAI J.Serum response factor:look into the gut［J］.World J Gastroenterol,2010,16(18):2195-2201.
［5］MIANO JM.Role of serum response factor in the pathogenesis of disease［J］.Lab Invest,2010,90(9):1274-1284.
［6］KIM HJ,KIM KR,PARK HS,et al.The expression and role of serum response factor in papillary carcinoma of the thyroid［J］.Int J Oncol,2009,35(1):49-55.
［7］HE X,XU H,ZHAO M,et al.Serum response factor is overexpressed in esophageal squamous cell carcinoma and promotes Eca-109 cell proliferation and invasion［J］.Oncol Lett,2013,5(3):819-824.
［8］ZHAO M,XU H,HE X,et al.Expression of serum response factor in gastric carcinoma and its molecular mechanisms involved in the regulation of the invasion and migration of SGC-7901 cells［J］.Cancer Biother Radiopharm,2013,28(2):146-152.
［9］ZHAO X,HE L,LI T,et al.SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancer［J］.Cell Death Differ,2014,21(12):1900-1913.
［10］CHOI HN,KIM KR,LEE JH,et al.Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex［J］.Oncol Rep,2009,21(1):57-63.
［11］KWON CY,KIM KR,CHOI HN,et al.The role of serum response factor in hepatocellular carcinoma:implications for disease progression［J］.Int J Oncol,2010,37(4):837-844.
［12］ZHAO L,LI C,JIANG W,et al.Serum response factor increases renal cell carcinoma migration and invasion through promoting epithelial-mesenchymal transition［J］.Int J Urol,2020,27(9):808-816.
［13］HU Q,GUO C,LI Y,et al.LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration［J］.Mol Cell Biol,2011,31(16):3223-3240.
［14］VERONE AR,DUNCAN K,GODOY A,et al.Androgen-responsive serum response factor target genes regulate prostate cancer cell migration［J］.Carcinogenesis,2013,34(8):1737-1746.
［15］YAMAGUCHI S,ASANOMA K,TAKAO T,et al.Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor［J］.Int J Cancer,2009,124(11):2577-2588.
［16］MA L,YU Y,QU X.Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr-1 and epithelial-mesenchymal transition［J］.Int J Mol Med,2019,43(1):614-620.
［17］刘爱军,王树伟,徐翔,等.血小板源性生长因子(PDGF)、血清反应因子(SRF)和波形蛋白在人脑胶质瘤中表达的临床意义［J］.复旦学报(医学版),2014,41(01):111-114，132.
LIU AJ,WANG SW,XU X,et al.Expression and clinical significance of platelet-derived growth factor (PDGF),serum response factor (SRF) and vimentin in human gliomas ［J］.Fudan Univ J Med Sci,2014,41(01):111-114，132.
［18］PELLEGRINO R,CALVISI DF,NEUMANN O,et al.EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma［J］.Hepatology,2014,59(5):1886-1899.
［19］LI T,WAN Y,SU Z,et al.SRF potentiates colon cancer metastasis and progression in a microRNA-214/PTK6-dependent manner［J］.Cancer Manag Res,2020,12:6477-6491.
［20］YE G,HUANG K,YU J,et al.MicroRNA-647 targets SRF-MYH9 axis to suppress invasion and metastasis of gastric cancer［J］.Theranostics,2017,7(13):3338-3353.
［21］BAE JS,NOH SJ,KIM KM,et al.Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma［J］.Int J Oncol,2014,44(1):129-136.
［22］KIM KR,BAE JS,CHOI HN,et al.The role of serum response factor in hepatocellular carcinoma:an association with matrix metalloproteinase［J］.Oncol Rep,2011,26(6):1567-1572.
［23］OHRNBERGER S,THAVAMANI A,BRAEUNING A,et al.Dysregulated serum response factor triggers formation of hepatocellular carcinoma［J］.Hepatology,2015,61(3):979-989.
［24］PELLEGRINO R,THAVAMANI A,CALVISI DF,et al.Serum response factor (SRF) drives the transcriptional upregulation of the MDM4 oncogene in HCC［J］.Cancers (Basel),2021,13(2):199.
［25］CORDENONSI M,ZANCONATO F,AZZOLIN L,et al.The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells［J］.Cell,2011,147(4):759-772.
［26］CREIGHTON CJ,LI X,LANDIS M,et al.Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features［J］.Proc Natl Acad Sci USA,2009,106(33):13820-13825.
［27］KIM T,YANG SJ,HWANG D,et al.A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness［J］.Nat Commun,2015,6:10186.
［28］LIU Y,LI M,YU H,et al.lncRNA CYTOR promotes tamoxifen resistance in breast cancer cells via sponging miR-125a-5p［J］.Int J Mol Med,2020,45(2):497-509.
［29］SAMAEEKIA R,ADORNO-CRUZ V,BOCKHORN J,et al.miR-206 inhibits stemness and metastasis of breast cancer by targeting MKL1/IL11 pathway［J］.Clin Cancer Res,2017,23(4):1091-1103.
［30］EVANS JC,MCCARTHY J,TORRES-FUENTES C,et al.Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro［J］.Gene Ther,2015,22(10):802-810.
［31］LUNDON DJ,BOLAND A,PRENCIPE M,et al.The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer:in-vitro discovery and in-vivo validation［J］.BMC Cancer,2017,17(1):163.
［32］LIONARONS DA,HANCOCK DC,RANA S,et al.RAC1(P29S) induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance［J］.Cancer Cell,2019,36(1):68-83.
［33］WHITSON RJ,LEE A,URMAN NM,et al.Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas［J］.Nature Med,2018,24(3):271-281.
［34］ONUH JO,QIU H.Serum response factor-cofactor interactions and their implications in disease［J］.Febs J,2021,288(10):3120-3134.
［35］LIU T,ZHANG H,YI S,et al.Mutual regulation of MDM4 and TOP2A in cancer cell proliferation［J］.Mol Oncol,2019,13(5):1047-1058.
［36］BABAEI G,AZIZ SG,JAGHI NZZ.EMT,cancer stem cells and autophagy;The three main axes of metastasis［J］.Biomed Pharmacother,2021,133:110909.
［37］OLSON EN,NORDHEIM A.Linking actin dynamics and gene transcription to drive cellular motile functions［J］.Nat Rev Mol Cell Biol,2010,11(5):353-365.
［38］WANG HY,TU YS,LONG J,et al.SRF-miR-29b-MMP2 axis inhibits NSCLC invasion and metastasis［J］.Int J Oncol,2015,47(2):641-649.
［39］LU J,SHENOY AK.Epithelial-to-pericyte transition in cancer［J］.Cancers (Basel),2017,9(7):77.
［40］TANABE S,QUADER S,CABRAL H,et al.Interplay of EMT and CSC in cancer and the potential therapeutic strategies［J］.Front Pharmacol,2020,11:904.
［41］MOYA IM,HALDER G.Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine［J］.Nat Rev Mol Cell Biol,2019,20(4):211-226.
［42］CHEN YA,LU CY,CHENG TY,et al.WW domain-containing proteins YAP and TAZ in the Hippo pathway as key regulators in stemness maintenance,tissue homeostasis,and tumorigenesis［J］.Front Oncol,2019,9:60.
［43］FOSTER CT,GUALDRINI F,TREISMAN R.Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics［J］.Genes Dev,2017,31(23-24):2361-2375.
［44］WATSON RW,AZAM H,AURA C,et al.Inhibition of serum response factor improves response to enzalutamide in prostate cancer［J］.Cancers (Basel),2020,12(12):3540.
［45］LIU JX,ZHOU GB,CHEN SJ,et al.Arsenic compounds:revived ancient remedies in the fight against human malignancies［J］.Curr Opin Chem Biol,2012,16(1-2):92-98.
［46］WANG QQ,JIANG Y,NARANMANDURA H.Therapeutic strategy of arsenic trioxide in the fight against cancers and other diseases［J］.Metallomics,2020,12(3):326-336.
［47］WANG HY,ZHANG B,ZHOU JN,et al.Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex［J］.Cell Death Dis,2019,10(6):453.
［48］KIKUCHI K,SHIOTA J,YAMADA T,et al.Rho signaling inhibitor,CCG-1423,inhibits axonal elongation and dendritic complexity of rat cortical neurons［J］.Biochem Biophys Res Commun,2017,492(3):474-479.
［49］戴夕超,陶累累,陈苏娟,等.SOX方案联合小牛脾提取物治疗老年胃癌的效果及对血清反应因子和血清氧调节蛋白水平的影响［J］.西北药学杂志,2019,34(04):534-537.
DAI XC,TAO LL,CHEN SJ,et al.Effect of SOX regimen combined with calf spleen extract on elderly patients with gastric cancer and its effect on serum SRF and ORP150 levels ［J］.Northwest Pharmaceutical Journal,2019,34(04):534-537.
［50］王玲,华海侠,王晓华,等.替莫唑胺治疗人恶性脑胶质瘤40例及对血清反应因子表达的影响［J］.中国药业,2015,24(21):81-83.
WANG L,HUA HX,WANG XH,et al.Treatment of 40 cases of human malignant glioma with temozolomide and its effect on serum reaction factor expression ［J］.China Pharmaceuticals,2015,24(21):81-83.
［51］梁阿铭,吕国伟,韩义娜.甘草酸对胶质瘤患者血清血小板衍生生长因子(PDGF)、白细胞介素17(IL-17)、单核细胞趋化蛋白-1(MCP-1)及血清反应因子SRF的影响［J］.中药药理与临床,2016,32(01):163-166.
LIANG AM,LYU GW,HAN YN.Effect of glycyrrhizin on serum levels of PDGF,IL-17,MCP-1 and serum response factor in patients with glioma ［J］.Pharmacology and Clinics of Chinese Materia Medica,2016,32(01):163-166.
［52］MEI Y,HAN X,LIU Y,et al.Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment［J］.Nat Commun,2020,11(1):3172.
［53］HUANG L,ZHAO L,ZHANG J,et al.Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways［J］.Aging (Albany NY),2021,13(13):17407-17427.
［54］GAU D,VEON W,CAPASSO TL,et al.Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis［J］.Angiogenesis,2017,20(4):663-672.
［55］MIANO JM.Serum response factor:toggling between disparate programs of gene expression［J］.J Mol Cell Cardiol,2003,35(6):577-593.
［56］IYER D,CHANG D,MARX J,et al.Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs［J］.Proc Natl Acad Sci USA,2006,103(12):4516-4521.
［57］RIVERA VM,MIRANTI CK,MISRA RP,et al.A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity［J］.Mol Cell Biol,1993,13(10):6260-6273.
［58］JOHANSEN FE,PRYWES R.Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs［J］.Mol Cell Biol,1993,13(8):4640-4647.
［59］JANKNECHT R,HIPSKIND RA,HOUTHAEVE T,et al.Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties［J］.Embo J,1992,11(3):1045-1054.
［60］CHANG J,WEI L,OTANI T,et al.Inhibitory cardiac transcription factor,SRF-N,is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading［J］.Circulation,2003,108(4):407-413.
［61］雷洪,王可可,哈艳平,等.血清反应因子全长及N端片段过表达慢病毒载体的构建及其对心脏干细胞分化的影响［J］.临床与实验病理学杂志,2017,33(10):1109-1115.
LEI H,WANG KK,HA YP,et al.Construction of the full length and N-terminal fragment of serum response factor over-expressing lentiviral plasmid and its impacts on cardiac stem cell differentiation［J］.J Clin Exp Pathol,2017,33(10):1109-1115.