|Table of Contents|

Research progress of immune checkpoint inhibitor therapy-immune-related venous thromboembolic events

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2023 13
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Research progress of immune checkpoint inhibitor therapy-immune-related venous thromboembolic events
LI HuiminLI HongLUO Qin
Department of Respiratory and Neurology,the Affiliated Tumor Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011,China.
cancer-associated venous thromboembolismimmune checkpoint inhibitorsimmune-related adverse eventsanticoagulant therapy
VTE,which includes pulmonary thromboembolism (PE) and deep vein thrombosis (DVT),is the second leading cause of death in cancer patients.Many factors can contribute to the increased risk of thrombosis in patients with cancer,especially treatment-related factors,such as surgery,chemotherapy,and more recently anti-angiogenesis agents.Currently,immune checkpoint inhibitors (ICIs) impair tumor immune-escape mechanisms by targeting programmed cell death 1 or its ligand (PD-1/PD-L1) or cytotoxic T-lymphocyte antigen 4 (CTLA-4).The most common ICIs adverse effects are immune-related adverse events (irAEs) that may potentially affect any organs or systems,including skin,thyroid,gastrointestinal,or hematological disorders such as autoimmune hemolytic anemia or thrombocytopenia.However,thrombosis had not been commonly reported as irAEs in landmark phase III clinical trials of ICIs.Therefore,there is a great need for clinicians to improve their understanding of ICIs-associated VTE events.This article reviews the VTE incidence,risk factors,its potential pathogenesis and management principles of VTE caused by ICIs treatment,thus guiding the implementation of clinical VTE prevention and treatment for patients on ICIs.


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National Natural Science Foundation of China(No.81760014);国家自然科学基金(编号:81760014);自治区科技支疆项目(编号:2019E0281);新疆维吾尔自治区自然科学基金资助项目(编号:2022D01D74)
Last Update: 2023-05-31