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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 13

Page:

2512-2518

Research Field:

Publishing date:

Info

Title:

Research progress of m6A-RNA methylated YTHDF1 binding protein in glioma

Author(s):

ZHU Lin; YU Tao; ZHENG Fakang; GONG Haidong

Department of Neurosurgery£¬Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Mudanjiang 157011£¬China.

Keywords:

YTHDF1; glioma; m6A methylation; cancer stem cells

PACS:

R739.41

DOI:

10.3969/j.issn.1672-4992.2023.13.027

Abstract:

Glioma is the most common primary intracranial malignant tumor,accounting for 45% of brain tumors.Currently,gliomas are mainly treated by surgery,but their infiltration growth and high recurrence rate lead to poor prognosis.At present,RNA modification,especially m6A methylation,is a hot spot in tumor research.With the continuous progress of high-throughput sequencing methods,the research on transcriptional epigenetics is also deepening.m6A (N6-methyladenosine) methylation is the most common modification in eukaryotic cells,especially in messenger RNA (message ribonucleic acid,mRNA).m6A methylation can affect the metabolism of RNA from many aspects such as RNA transcription,nuclear export,translation,decay,etc.It participates in the embryonic development of organisms,circadian rhythm,stress response,and even the occurrence of tumors.YTHDF1,the highest expression of m6A methylated recognition protein in glioma can recognize and induce target translation.This article will combine recent research progress,focusing on the mode of action,biological characteristics,development of gliomas,and existing potential effects of the m6A binding protein YTHDF1.

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Common functions

Last Update: 2023-05-31