|Table of Contents|

Regulation mechanism of necroptosis and its role in cancer pathogenesis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 22
Page:
3690-3695
Research Field:
Publishing date:

Info

Title:
Regulation mechanism of necroptosis and its role in cancer pathogenesis
Author(s):
Li Li12Liu Li12Luo Ning12Cheng Zhongping12
1.Department of Obstetrics and Gynecology,Yangpu Hospital,Tongji University School of Medicine,Shanghai 200090,China; 2.Institute of Gynecological Minimally Invasive Medicine,Tongji University School of Medicine,Shanghai 200090,China
Keywords:
apoptosisnecroptosiscancerRIPK3MLKL
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2018.22.042
Abstract:
Necroptosis is a caspase-independent form of programmed cell death mediated by RIPK1/RIPK3(receptor-interacting protein kinase 1/3) and MLKL(mixed-line kinase domain-like protein),with the same morphological characteristics of necrosis.Necroptosis has dual roles in the pathogenesis of cancer.It can eliminate and kill the apoptosis-resistant cancer cells alternatively and play a role in anti-cancer effect.It can also stimulate the cancer microenvironment inflammatory responses promoting tumor development,invasion and metastasis.This review summarizes the research progress on mechanism of necroptosis and its biological effects and pathological significance in tumor progression.

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上海市医学重点专科建设项目(编号:ZA2015A33)
Last Update: 2018-09-30