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Changes of serum TK1 level in breast cancer patients with resection after ozone therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2017 18
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Changes of serum TK1 level in breast cancer patients with resection after ozone therapy
Qin Zilin1Zeng Jianying2Xing Yanli2Zhang Naihai2Niu Lizhi2
1.Jinan University,Medical College,Guangdong Guangzhou 510632,China;2.Central Lab,Fuda Cancer Hospital,Jinan University School of Medicine,Guangdong Guangzhou 510665,China.
ozone therapybreast cancerthymidine kinase-1(TK1)
Objective:To investigate the changes of serum TK1 levels in patients of breast cancer with resection after ozone therapy,and explore the relationship between the changes of TK1 and tumor stage.Methods:Serum TK1 levels were detected in 104 breast cancer patients with resection before and after ozone therapy by enzyme immunoassay dot blot chemiluminesence assay.To compare the difference of TK1、CA15-3 and CEA in breast cancer patients with different clinical stages before and after three oxygen therapy,and to analyze the relationship between TK1 and estrogen receptor(ER) and progesterone receptor(PR).Results:The average TK1 in breast cancer patients before three oxygen therapy was (1.52±1.53) pmol/L,compared with the healthy group (0.54±0.42) pmol/L,the difference was statistically significant(P=0.000).The mean value of TK1 after three oxygen treatment was (0.73±0.82) pmol/L,compared with before treatment,the difference was statistically significant(P=0.001).According to clinical stage,the average TK1 in stage I-III patients before treatment was (1.05±1.17) pmol/L,after treatment average was (0.38±0.44) pmol/L,the difference was statistically significant(P=0.002).The average TK1 in stage IV patients before treatment was (2.53±1.73) pmol/L,after treatment average was (1.47±0.94) pmol/L,the difference was not statistically significant(P=0.080).There was no significant difference in CA15-3 and CEA before and after three oxygen treatment(P>0.05),but the CA15-3 and CEA in stage I-III patients had consistency with TK1 change trend.The level of TK1 was related to PR and ER(r=0.455,P=0.000).Conclusion:Ozone therapy can effectively reduce the TK1 level of breast cancer patients after resection,inhibit the proliferation of tumor cells,control the disease progression,and it is more significant for patients with stage I to III.


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