|Table of Contents|

Changes of serum TK1 level in breast cancer patients with resection after ozone therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 18
Page:
2915-2918
Research Field:
Publishing date:

Info

Title:
Changes of serum TK1 level in breast cancer patients with resection after ozone therapy
Author(s):
Qin Zilin1; Zeng Jianying2; Xing Yanli2; Zhang Naihai2; Niu Lizhi2
1.Jinan University,Medical College,Guangdong Guangzhou 510632,China；2.Central Lab,Fuda Cancer Hospital,Jinan University School of Medicine,Guangdong Guangzhou 510665,China.
Keywords:
ozone therapy; breast cancer; thymidine kinase-1(TK1)
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.18.015
Abstract:
Objective:To investigate the changes of serum TK1 levels in patients of breast cancer with resection after ozone therapy,and explore the relationship between the changes of TK1 and tumor stage.Methods:Serum TK1 levels were detected in 104 breast cancer patients with resection before and after ozone therapy by enzyme immunoassay dot blot chemiluminesence assay.To compare the difference of TK1、CA15-3 and CEA in breast cancer patients with different clinical stages before and after three oxygen therapy,and to analyze the relationship between TK1 and estrogen receptor(ER) and progesterone receptor(PR).Results:The average TK1 in breast cancer patients before three oxygen therapy was （1.52±1.53） pmol/L,compared with the healthy group （0.54±0.42） pmol/L,the difference was statistically significant(P=0.000).The mean value of TK1 after three oxygen treatment was (0.73±0.82) pmol/L,compared with before treatment,the difference was statistically significant（P=0.001）.According to clinical stage,the average TK1 in stage I-III patients before treatment was （1.05±1.17） pmol/L,after treatment average was （0.38±0.44） pmol/L,the difference was statistically significant（P=0.002）.The average TK1 in stage IV patients before treatment was （2.53±1.73） pmol/L,after treatment average was （1.47±0.94） pmol/L,the difference was not statistically significant（P=0.080）.There was no significant difference in CA15-3 and CEA before and after three oxygen treatment（P＞0.05）,but the CA15-3 and CEA in stage I-III patients had consistency with TK1 change trend.The level of TK1 was related to PR and ER（r=0.455,P=0.000）.Conclusion:Ozone therapy can effectively reduce the TK1 level of breast cancer patients after resection,inhibit the proliferation of tumor cells,control the disease progression,and it is more significant for patients with stage I to III.

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