|Table of Contents|

The value of thyroglobulin detection in the differential diagnosis of benign and malignant thyroid nodules

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 05
Page:
784-790
Research Field:
Publishing date:

Info

Title:
The value of thyroglobulin detection in the differential diagnosis of benign and malignant thyroid nodules
Author(s):
ZHANG Yuping1; YIN Fengyan2; ZHANG Hui3; LUO Xiaoting4; CAO Wenyuan4; HE Qian4; XING Hao2; ZHAO Hongjian5
Keywords:
thyroglobulin; thyroid nodule; papillary thyroid carcinoma; diagnostic value; prediction
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2025.05.010
Abstract:
Objective:To investigate the clinical value of preoperative serum thyroglobulin(PS-Tg) in differential diagnosis between benign and malignant thyroid nodules.Methods:Collect clinical and pathological data of patients undergoing thyroidectomy,perform logistic regression analysis on the relationship between PS-Tg and benign and malignant thyroid nodules,draw a nomogram to quantify the relationship between the two,and determine the optimal cutoff value through the ROC curve.Results:The levels of PS-Tg in the malignant group were higher than those in the benign group (t=7.525,P＜0.05).Regression analysis revealed that an increase in PS-Tg levels may be an independent risk factor of papillary thyroid carcinoma (PTC),and an increase in PS-Tg levels can explain approximately 55% of the PTC risk.The area under the ROC curve was used to evaluate the AUC of PS-Tg for predicting benign and malignant thyroid nodules,which was 0.707 5.The AUC for males and females were 0.590 4 and 0.733 7,respectively.Conclusion:Elevated PS-Tg levels may be a risk factor for PTC patients,and the female population has good predictive value for the diagnosis of benign and malignant thyroid nodules compared to the male population.

References:

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Memo

Memo:
山东省自然科学基金（编号：ZR2023QH135）；山东省泰安市科技创新课题（编号：2022NS234)
Last Update: 1900-01-01