|Table of Contents|

Dosimetric comparison of different radiotherapy techniques in whole breast irradiation after breast-conserving surgery for left breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 04
Page:
598-606
Research Field:
Publishing date:

Info

Title:
Dosimetric comparison of different radiotherapy techniques in whole breast irradiation after breast-conserving surgery for left breast cancer
Author(s):
NING Jing; ZHAO Zhipeng; GUO Xin; WU Ning
Department of Radiation Oncology,China-Japan Union Hospital of Jilin University,Jilin Changchun 130033,China.
Keywords:
radiotherapy; breast cancer; dosimetry
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2025.04.008
Abstract:
Objective:To compare the dosimetric differences of the four techniques in whole breast irradiation after breast-conserving surgery for left breast cancer,and to analyze the clinical application advantages of each technique.Methods:20 patients with left breast cancer after breast-conserving surgery were selected for the design of simulation plans for intensity modulated radiation therapy,volumetric modulated arc therapy,helical tomotherapy and direct tomotherapy.The differences in dosimetry parameters of the planning target volume and organs at risk by the four radiotherapy technological plans were analyzed and evaluated.Results:The four radiotherapy techniques can meet the clinical requirements of whole breast irradiation after breast-conserving surgery for left breast cancer.Among them,the target uniformity of helical tomotherapy technique was better than other technologies.While the volumetric modulated arc therapy had better target conformability (P＜0.05).Compared with other radiotherapy techniques,helical tomotherapy technique significantly decreased the exposure dose of the heart (Dmax,V30 and V20),left anterior descending coronary arterie (Dmean,Dmax,D2%,V30,V10 and V5) and the ipsilateral lung (V40 and V20) (P=0.00).Moreover,volumetric modulated arc therapy technique has the protection effect for the skin within the irradiation field (D10cc,V50,V40,V30,D5%,and D2%)(P＜0.05).Conclusion:For the whole breast irradiation after breast-conserving surgery for left breast cancer,the plan designed by helical tomotherapy technology has certain comparative advantages.The design of radiotherapy plan should comprehensively weigh the dosimetric benefits of the target area and organs at risk,and individualized selection of appropriate radiation therapy techniques.

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Memo

Memo:
National Natural Science Foundation of China(No.81201737）；国家自然科学基金项目（编号：81201737）；吉林省科技发展计划资助项目（编号：20200201524JC）；吉林省教育厅科学技术研究项目（编号：JJKH20211196KJ）；吉林省财政厅卫生科研人才专项项目（编号：2024SCZ66）;吉林大学技术开发（委托）项目（编号：2023220103000073）
Last Update: 1900-01-01