|Table of Contents|

Research progress and future perspectives of gut microbiota in endocrine therapy for hormone receptor-positive breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 02
Page:
298-302
Research Field:
Publishing date:

Info

Title:
Research progress and future perspectives of gut microbiota in endocrine therapy for hormone receptor-positive breast cancer
Author(s):
YAO PeizhuoFANG BiyunLI ChaofanJIA YiweiWEI XinyuZHANG Shuqun
The Comprehensive Breast Care Center,the Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
hormone receptor-positive breast cancergut microbiotaendocrine therapyestrogenβ-glucuronidas
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2025.02.020
Abstract:
Hormone receptor-positive breast cancer is the most common subtype of breast cancer and is closely related to estrogen metabolism disorders.Gut microbiota play a significant role in regulating human physiological metabolism.Based on the concept of the "estrobolome",gut microbiota have become a research hotspot in the pathogenesis and therapeutic intervention of breast cancer.This review summarizes the current research status of gut microbiota in hormone receptor-positive breast cancer,discusses potential pathogenic mechanisms,and analyzes the interactions between gut microbiota and endocrine therapy agents,as well as their impact on treatment sensitivity and resistance.Furthermore,the article highlights the therapeutic potential of gut microbiota in future treatments of hormone receptor-positive breast cancer and points out the limitations of existing studies and future research directions,aiming to provide important insights for understanding the pathogenesis and personalized treatment of hormone receptor-positive breast cancer.

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Memo

Memo:
National Natural Science Foundation of China(No.82174164);国家自然科学基金项目(编号:82174164);陕西省自然科学基础研究计划项目(编号:2023-JC-YB-758)
Last Update: 1900-01-01