|Table of Contents|

Effect of propofol and remimazolam benzenesulfonate on intracranial pressure and quality of postoperative awakening in patients underwent laparoscopy surgeries with gynecological tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 02
Page:
281-287
Research Field:
Publishing date:

Info

Title:
Effect of propofol and remimazolam benzenesulfonate on intracranial pressure and quality of postoperative awakening in patients underwent laparoscopy surgeries with gynecological tumors
Author(s):
LENG Lin1; JIN Yeyuan2; HE Zongzhao2; ZHANG Lingmin3; LI Fugui2
1.Graduate School of Qinghai University，Qinghai Xining 810016，China；2.Department of Anesthesiology，Qinghai Provincial People's Hospital，Qinghai Xining 810007，China；3.The First Affiliated Hospital of Xi'an Jiaotong University，Shaanxi Xi'an 710061，China.
Keywords:
remimazolam benzenesulfonate; intracranial pressure; optic nerve sheath diameter; laparoscopy; trendelenburg position
PACS:
R737.3
DOI:
10.3969/j.issn.1672-4992.2025.02.017
Abstract:
Objective:To apply ultrasound measurement of optic nerve sheath diameter (ONSD) to evaluate the effects of propofol and remimazolam benzenesulfonate on intracranial pressure and quality of postoperative awakening in patients who underwent laparoscopy surgeries with gynecological tumors.Methods:Forty-two patients underwent laparoscopy surgeries with gynecological tumors,with age 18~65 years old,body mass index (BMI) 18.0~27.0 kg/m2,ASA classification I-II.Patients were randomly divided into propofol group (P group) and remimazolam group (R group),21 cases in each group.Propofol was intravenously pumped in group P,and remimazolam was intravenously pumped in group R.Remifentanil was pumped intravenously in both groups and rocuronium bromide was added on time.Volume-controlled ventilation mode was used with VT 6~8 mL/kg,inspiratory/expiratory ratio 1∶2,FiO2 50%,and RR 12~18 times/min.ONSD was recorded at 5 min after intubation of anaesthesia (T0),immediately (T1),30 min (T2),60 min (T3),90 min (T4) after pneumoperitoneum head-down position,and at the end of the pneumoperitoneum after resumption of the flat lying position for 10 min (T5).The time of extubation,modified observer's assessment of alert/sedation (MOAA/S) at 5 min after extubation,and the length of stay in postanesthesia care unit (PACU) were recorded.Results:Compared with T0,the ONSD values were significantly higher in both groups at T1~T4 time points (P＜0.05).There was no statistically significant difference in the quality of postoperative awakening between the two groups （P>0.05）.Conclusion:The anaesthetic effect of remimazolam benzenesulfonate for laparoscopic surgeries with gynecological tumors was comparable to that of propofol without increasing ONSD and intracranial pressure,while there was no significant difference in the quality of postoperative awakening between the two groups.

References:

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Memo

Memo:
2023年青海省“昆仑英才·高层次卫生健康人才”项目（编号：青人才字〔2023〕9号， 青人才字〔2023〕10号）；青海省人民医院院内课题（编号：2023-qhsrmyy-16）
Last Update: 1900-01-01